Infants and Lipid Soluble drugs
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decreased volume distribution, less plasma proteins for binding, require
higher doses of hydrophilic drugs
Pediatric skin absorption
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Kids have thinner stratum corneum so topical medications are absorbed
more readily: increased risk of toxicity
Concerns for achlorhydria in elderly
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decreased gastric pH changes availability of pH sensitive drugs such as
proton pump inhibitor, some drugs are less absorbed in higher pH levels.
Pediatric GI function
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pH increases gradually- reaches adult levels @ 20-30 months preemies are
even slower
Serum Creatinine in Elderly
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while it is most reliable in determining kidney function, it is not reliable in
older adults and nutrition can affect the test
Give this one a try later!
decreased volume distribution, less plasma proteins for binding, require
higher doses of hydrophilic drugs
Pediatric skin absorption
, Give this one a try later!
Kids have thinner stratum corneum so topical medications are absorbed
more readily: increased risk of toxicity
Concerns for achlorhydria in elderly
Give this one a try later!
decreased gastric pH changes availability of pH sensitive drugs such as
proton pump inhibitor, some drugs are less absorbed in higher pH levels.
Pediatric GI function
Give this one a try later!
pH increases gradually- reaches adult levels @ 20-30 months preemies are
even slower
Serum Creatinine in Elderly
Give this one a try later!
while it is most reliable in determining kidney function, it is not reliable in
older adults and nutrition can affect the test
