HTHS 2240 WSU Exam 4 Revision
Questions and Already Passed Answers.
inflammatory mediators - Answer Help heal, but cause pain and swelling
Pain, heat, redness, swelling - Answer NSAIDs, ice, immobilization
Rheumatoid arthritis, dermatitis, asthma, lupus, Crohn's disease, gout, anaphylaxis - Answer
Chronic inflammation examples that require corticosteroid therapy
cortical steroids - Answer Derived from cholesterol, group of steroid hormones (endogenous)
cortisol used in times of stress
Cortisol - Answer Outer part (cortex) of adrenal gland
Functions of cortisol - Answer Modulate glucose levels and body responses to stress, decrease
the inflammatory response
Mechanisms of action of corticosteroids - Answer Do everything plus to help in inflammation
Corticosteroids effect on arachidonic acid pathway - Answer Corticosteroids are better anti
inflammatories than COX inhibs (aspirin) because they inhib all aspects of the A.A cascade
Eicosanoids - Answer Local hormones
Arachidonic acid pathway - Answer Tissue injury-> membrane lipids-> arachidonic acid-> COX I
(reg PG/TXA)/COX II (inflamm PG/TXA)/Lipoxegenase (leukotrienes)
Leuotrienes - Answer Produced from the lipoxygenase enzyme
HISTORY: Corticosteroids short term - Answer In 1950s the drugs appeared to be free of side
effects
, Corticosteroid systemic Use - Answer Creams, ointments, eye drops, ear drops
Prednisone (Deltasone) - Answer Corticosteroid systemic use, oral
Kenalog (Triamcinolone) - Answer Corticosteroid systemic use, I.M "allergy shot"
Soul-Medrol (methylprednisolone) - Answer Corticosteroid systemic use, I.V, emergency
anaphylactic reactions
sex steroids - Answer Also made from cholesterol, Secondary sexual characteristics in men and
women and libido, no anti inflammatory properties
Anabolic androgen steroids AAS - Answer "Roads" "Arnold's" mimic the effects of testosterone
Testosterone and dihydrotestosterone (DHT) - Answer Male androgen hormones
Estradiol (E2) - Answer Female estrogens
Side effects of AAS - Answer Aggressive behavior, decreased sperm counts, shrunken testes,
baldness, hirsutism
Schedule III - Answer All anabolic steroids are what schedule of drugs?
Dianabol(methandrostenolone) - Answer First anabolic steroid in US
hGH (human growth hormone) - Answer Non steroid, protein based hormone
r-hGH genotropin - Answer Often abused alongside AAS
Abusing hGH - Answer Stimulation of muscle growth, loss of fat, increased glucose output
from the liver
Questions and Already Passed Answers.
inflammatory mediators - Answer Help heal, but cause pain and swelling
Pain, heat, redness, swelling - Answer NSAIDs, ice, immobilization
Rheumatoid arthritis, dermatitis, asthma, lupus, Crohn's disease, gout, anaphylaxis - Answer
Chronic inflammation examples that require corticosteroid therapy
cortical steroids - Answer Derived from cholesterol, group of steroid hormones (endogenous)
cortisol used in times of stress
Cortisol - Answer Outer part (cortex) of adrenal gland
Functions of cortisol - Answer Modulate glucose levels and body responses to stress, decrease
the inflammatory response
Mechanisms of action of corticosteroids - Answer Do everything plus to help in inflammation
Corticosteroids effect on arachidonic acid pathway - Answer Corticosteroids are better anti
inflammatories than COX inhibs (aspirin) because they inhib all aspects of the A.A cascade
Eicosanoids - Answer Local hormones
Arachidonic acid pathway - Answer Tissue injury-> membrane lipids-> arachidonic acid-> COX I
(reg PG/TXA)/COX II (inflamm PG/TXA)/Lipoxegenase (leukotrienes)
Leuotrienes - Answer Produced from the lipoxygenase enzyme
HISTORY: Corticosteroids short term - Answer In 1950s the drugs appeared to be free of side
effects
, Corticosteroid systemic Use - Answer Creams, ointments, eye drops, ear drops
Prednisone (Deltasone) - Answer Corticosteroid systemic use, oral
Kenalog (Triamcinolone) - Answer Corticosteroid systemic use, I.M "allergy shot"
Soul-Medrol (methylprednisolone) - Answer Corticosteroid systemic use, I.V, emergency
anaphylactic reactions
sex steroids - Answer Also made from cholesterol, Secondary sexual characteristics in men and
women and libido, no anti inflammatory properties
Anabolic androgen steroids AAS - Answer "Roads" "Arnold's" mimic the effects of testosterone
Testosterone and dihydrotestosterone (DHT) - Answer Male androgen hormones
Estradiol (E2) - Answer Female estrogens
Side effects of AAS - Answer Aggressive behavior, decreased sperm counts, shrunken testes,
baldness, hirsutism
Schedule III - Answer All anabolic steroids are what schedule of drugs?
Dianabol(methandrostenolone) - Answer First anabolic steroid in US
hGH (human growth hormone) - Answer Non steroid, protein based hormone
r-hGH genotropin - Answer Often abused alongside AAS
Abusing hGH - Answer Stimulation of muscle growth, loss of fat, increased glucose output
from the liver
