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Summary Lehne's Pharmacotherapeutics for Advanced Practice Nurses and Physician Assistants - E-Book - 6521 pharmacotherapeutic

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1. Genetic Differences Genes affect how people metabolize drugs. o Some individuals break drugs down too quickly, leading to low effectiveness. o Others metabolize slowly, risking toxicity. o Pharmacogenetic testing can guide therapy—especially for drugs like warfarin or antidepressants

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Institution
6521 Pharmacotherapeutic
Course
6521 pharmacotherapeutic

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Chapter 1
Prescriptive Authority
1. Independent Prescribing Defined
A nurse practitioner (NP) working in a state where no physician oversight is required and
where no employer-imposed limitations exist is said to have independent prescriptive
authority. This means the NP can prescribe without needing approval from another
provider. Though the term “full authority” is also used, "independent" more precisely
describes the legal freedom to prescribe.
2. Why Full Prescriptive Authority Is Important
One reason there’s been a push for full prescriptive rights among NPs is the expanding
demand for healthcare services. The implementation of the Affordable Care Act brought
healthcare access to more people, increasing the need for providers who can prescribe
without delay. Empowering NPs to do so improves access and efficiency.
3. Consequences of Prescribing Restrictions
Restrictions on NP prescribing rights can create delays in care, reduce access in
underserved areas, and increase treatment costs. These restrictions can also make
collaboration between healthcare providers more difficult, although they don’t
necessarily impact health literacy or improve care quality.
4. Supporting Evidence for Prescriptive Authority
NPs are trained extensively in pharmacology and disease management. Their competence
is verified through national board certification and licensure, both of which support safe
and effective prescribing. These qualifications justify the push for full authority.
5. State-to-State Differences
Prescriptive authority is determined at the state level. A nurse practitioner moving from a
state with full authority (like Maine) to one with restrictions (like Virginia) will lose
some of their autonomy. This variation underscores the importance of knowing local
laws.

,Chapter 2:
Rational Drug
Selection and
Prescription Writing
1. Partnering with Pharmacists
Collaborating with pharmacists helps improve medication safety. They assist in catching
potential drug interactions, recommend proper dosages, and offer cost-effective
alternatives based on formulary restrictions. While pharmacists can advise, only the
prescriber can authorize medication changes.
2. Emergency Medication Orders
In urgent situations—such as alcohol withdrawal accompanied by seizures—a provider
may issue a verbal order for an immediate medication (e.g., lorazepam) if they cannot
physically sign a prescription in time. This ensures that the patient receives critical
treatment without delay.
3. Refilling Controlled Substances
Drugs like oxycodone (a Schedule II medication) require a new written prescription each
time a refill is needed. These cannot be called in or automatically refilled. Reassessment
of the patient's condition—preferably in person—is necessary before issuing each new
prescription.
4. Handling Adverse Reactions
If a patient develops a symptom (e.g., a rash) after starting a new drug such as
amoxicillin, the immediate action should be to stop the medication. This helps prevent
worsening of the reaction or potential complications.
5. Managing Drug Interactions in Complex Cases
For patients on multiple medications—especially those with chronic illnesses—it's
important to review their entire medication list before starting a new drug. This prevents
adverse drug interactions and ensures compatibility among all medications.

, 6. Addressing Cost Barriers
When a patient says they can’t afford their prescribed medication (such as insulin), it’s
the provider’s responsibility to offer solutions. These can include offering samples,
switching to a generic version, or directing the patient to lower-cost pharmacies or
assistance programs.
7. Completing Controlled Substance Prescriptions
For prescriptions involving controlled substances (especially Schedule II drugs), all
required information—such as DEA number, drug name, dose, quantity, and route—must
be complete. Pharmacists will not fill incomplete or inaccurate prescriptions, leading to
treatment delays.

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Institution
6521 pharmacotherapeutic
Course
6521 pharmacotherapeutic

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Summarized whole book?
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Chapter 1 to chapter 10
Uploaded on
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Number of pages
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Written in
2024/2025
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