USMLE Step 1 - uWorld High Yield
Questions and Answers | Latest
Version | 2025/2026 | Correct & Verified
Which renal pathology presents with spike and dome appearance on EM?
✔✔ Membranous nephropathy
Which metabolic disorder causes mousy body odor in infants?
✔✔ Phenylketonuria
Which neurotransmitter is decreased in Parkinson disease?
✔✔ Dopamine
Which gene mutation is associated with familial adenomatous polyposis?
✔✔ APC gene
Which microbe is the most common cause of meningitis in neonates?
✔✔ Group B Streptococcus
1
,Which vitamin deficiency leads to night blindness?
✔✔ Vitamin A deficiency
Which enzyme is deficient in alkaptonuria?
✔✔ Homogentisate oxidase
Which type of necrosis is typical of myocardial infarction?
✔✔ Coagulative necrosis
Which bacteria causes pseudomembranous colitis after antibiotic use?
✔✔ Clostridioides difficile
Which cytokine is the primary mediator of septic shock?
✔✔ TNF-alpha
Which cell surface marker is specific to helper T cells?
✔✔ CD4
2
,Which glycogen storage disease presents with hypoglycemia and hepatomegaly but normal
kidneys?
✔✔ Von Gierke disease
Which hormone is responsible for maintaining corpus luteum in early pregnancy?
✔✔ hCG
Which enzyme catalyzes the conversion of androgens to estrogens?
✔✔ Aromatase
Which part of the nephron is most sensitive to ischemic injury?
✔✔ Proximal tubule
Which immunoglobulin crosses the placenta?
✔✔ IgG
Which class of antibiotics inhibits transpeptidase in bacterial cell wall synthesis?
✔✔ Beta-lactams
3
, Which brain region is lesioned in hemiballismus?
✔✔ Subthalamic nucleus
Which bacterial component triggers septic shock through TLR4?
✔✔ Lipid A of LPS
Which antifungal binds to ergosterol and forms membrane pores?
✔✔ Amphotericin B
Which enzyme deficiency causes increased orotic acid with hyperammonemia?
✔✔ Ornithine transcarbamylase deficiency
Which artery is involved in epidural hematoma?
✔✔ Middle meningeal artery
Which immunoglobulin is produced first during an immune response?
✔✔ IgM
4
Questions and Answers | Latest
Version | 2025/2026 | Correct & Verified
Which renal pathology presents with spike and dome appearance on EM?
✔✔ Membranous nephropathy
Which metabolic disorder causes mousy body odor in infants?
✔✔ Phenylketonuria
Which neurotransmitter is decreased in Parkinson disease?
✔✔ Dopamine
Which gene mutation is associated with familial adenomatous polyposis?
✔✔ APC gene
Which microbe is the most common cause of meningitis in neonates?
✔✔ Group B Streptococcus
1
,Which vitamin deficiency leads to night blindness?
✔✔ Vitamin A deficiency
Which enzyme is deficient in alkaptonuria?
✔✔ Homogentisate oxidase
Which type of necrosis is typical of myocardial infarction?
✔✔ Coagulative necrosis
Which bacteria causes pseudomembranous colitis after antibiotic use?
✔✔ Clostridioides difficile
Which cytokine is the primary mediator of septic shock?
✔✔ TNF-alpha
Which cell surface marker is specific to helper T cells?
✔✔ CD4
2
,Which glycogen storage disease presents with hypoglycemia and hepatomegaly but normal
kidneys?
✔✔ Von Gierke disease
Which hormone is responsible for maintaining corpus luteum in early pregnancy?
✔✔ hCG
Which enzyme catalyzes the conversion of androgens to estrogens?
✔✔ Aromatase
Which part of the nephron is most sensitive to ischemic injury?
✔✔ Proximal tubule
Which immunoglobulin crosses the placenta?
✔✔ IgG
Which class of antibiotics inhibits transpeptidase in bacterial cell wall synthesis?
✔✔ Beta-lactams
3
, Which brain region is lesioned in hemiballismus?
✔✔ Subthalamic nucleus
Which bacterial component triggers septic shock through TLR4?
✔✔ Lipid A of LPS
Which antifungal binds to ergosterol and forms membrane pores?
✔✔ Amphotericin B
Which enzyme deficiency causes increased orotic acid with hyperammonemia?
✔✔ Ornithine transcarbamylase deficiency
Which artery is involved in epidural hematoma?
✔✔ Middle meningeal artery
Which immunoglobulin is produced first during an immune response?
✔✔ IgM
4
