Pharmacotherapeutics for Advanced
Practice Nurse Prescribers Questions
and Answers | Latest Version |
2025/2026 | Correct & Verified
A client with chronic back pain is requesting a refill for oxycodone. What is the most appropriate
next step for the advanced practice nurse?
✔✔Review the prescription drug monitoring program and reassess pain and function before
refilling.
An adult client is starting hydrochlorothiazide. What is the most important lab value to monitor?
✔✔Serum potassium level.
A client has been prescribed metoprolol succinate for hypertension. What is an important
teaching point?
✔✔Do not stop the medication suddenly, as it may cause rebound hypertension.
An elderly client is prescribed amitriptyline for neuropathic pain. What adverse effect should be
monitored closely?
✔✔Orthostatic hypotension and anticholinergic symptoms like dry mouth and constipation.
1
,A client on long-term NSAID therapy for osteoarthritis complains of stomach pain. What is the
best pharmacologic strategy to prevent complications?
✔✔Add a proton pump inhibitor like omeprazole for gastric protection.
A patient with type 2 diabetes is starting a GLP-1 receptor agonist. What common side effect
should the nurse practitioner prepare the patient for?
✔✔Nausea, especially during the first few weeks of therapy.
A client with newly diagnosed atrial fibrillation is prescribed apixaban. What should the provider
assess before starting therapy?
✔✔Renal function using creatinine clearance.
A pregnant client in her first trimester has a urinary tract infection. What is the safest first-line
antibiotic to prescribe?
✔✔Nitrofurantoin, avoiding use in late third trimester.
A client is prescribed isosorbide mononitrate for angina prevention. What instruction is essential
for proper dosing?
2
, ✔✔Ensure a nitrate-free interval each day to prevent tolerance.
A client with severe asthma is not responding to high-dose inhaled corticosteroids and long-
acting beta-agonists. What advanced therapy might be considered?
✔✔Monoclonal antibody therapy targeting IgE or eosinophils.
A patient being treated for hypothyroidism reports fatigue and cold intolerance. What is the most
appropriate next step?
✔✔Check TSH levels and adjust levothyroxine as needed.
A client with depression is not responding to SSRI therapy. What should the nurse practitioner
evaluate before considering medication changes?
✔✔Assess for adherence and adequate duration of therapy.
A client on lisinopril develops a dry cough. What is the best pharmacologic alternative?
✔✔Switch to an angiotensin receptor blocker (ARB) like losartan.
A client on carbamazepine for seizure control develops a fever and sore throat. What is the most
appropriate next step?
3
Practice Nurse Prescribers Questions
and Answers | Latest Version |
2025/2026 | Correct & Verified
A client with chronic back pain is requesting a refill for oxycodone. What is the most appropriate
next step for the advanced practice nurse?
✔✔Review the prescription drug monitoring program and reassess pain and function before
refilling.
An adult client is starting hydrochlorothiazide. What is the most important lab value to monitor?
✔✔Serum potassium level.
A client has been prescribed metoprolol succinate for hypertension. What is an important
teaching point?
✔✔Do not stop the medication suddenly, as it may cause rebound hypertension.
An elderly client is prescribed amitriptyline for neuropathic pain. What adverse effect should be
monitored closely?
✔✔Orthostatic hypotension and anticholinergic symptoms like dry mouth and constipation.
1
,A client on long-term NSAID therapy for osteoarthritis complains of stomach pain. What is the
best pharmacologic strategy to prevent complications?
✔✔Add a proton pump inhibitor like omeprazole for gastric protection.
A patient with type 2 diabetes is starting a GLP-1 receptor agonist. What common side effect
should the nurse practitioner prepare the patient for?
✔✔Nausea, especially during the first few weeks of therapy.
A client with newly diagnosed atrial fibrillation is prescribed apixaban. What should the provider
assess before starting therapy?
✔✔Renal function using creatinine clearance.
A pregnant client in her first trimester has a urinary tract infection. What is the safest first-line
antibiotic to prescribe?
✔✔Nitrofurantoin, avoiding use in late third trimester.
A client is prescribed isosorbide mononitrate for angina prevention. What instruction is essential
for proper dosing?
2
, ✔✔Ensure a nitrate-free interval each day to prevent tolerance.
A client with severe asthma is not responding to high-dose inhaled corticosteroids and long-
acting beta-agonists. What advanced therapy might be considered?
✔✔Monoclonal antibody therapy targeting IgE or eosinophils.
A patient being treated for hypothyroidism reports fatigue and cold intolerance. What is the most
appropriate next step?
✔✔Check TSH levels and adjust levothyroxine as needed.
A client with depression is not responding to SSRI therapy. What should the nurse practitioner
evaluate before considering medication changes?
✔✔Assess for adherence and adequate duration of therapy.
A client on lisinopril develops a dry cough. What is the best pharmacologic alternative?
✔✔Switch to an angiotensin receptor blocker (ARB) like losartan.
A client on carbamazepine for seizure control develops a fever and sore throat. What is the most
appropriate next step?
3
