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ONS/ONCC Chemotherapy &
Immunotherapy Certificate Exam
2025/2026 – 50 Verified Questions with
Correct Answers
Hazardous Drug Handling
1. A nurse is preparing to administer a hazardous drug (HD). Which personal protective
equipment (PPE) is required per USP <800> standards?
A. Single pair of gloves
B. Two pairs of chemotherapy-tested gloves and a gown
C. Face mask only
D. Standard surgical gloves
Rationale: USP <800> requires two pairs of chemotherapy-tested gloves and a gown to
minimize exposure during HD handling.
2. A nurse accidentally spills a hazardous drug. What is the first action to take?
A. Wipe with a dry cloth
B. Use a spill kit with appropriate PPE
C. Flush with water
D. Continue working
Rationale: Using a spill kit with PPE ensures safe cleanup and prevents exposure to
hazardous drugs.
3. Which practice reduces hazardous drug exposure when disposing of patient waste?
A. Flushing the toilet with the lid up
B. Flushing with the lid down or using a plastic-backed pad
C. Disposing waste in regular trash
D. Handling waste without gloves
Rationale: Flushing with the lid down or using a plastic-backed pad minimizes
aerosolized HD contamination.
4. A nurse is pregnant. What does ASCO/ONS recommend regarding HD handling?
A. Continue handling HDs
B. Offer alternative duties to avoid exposure
C. Use single-layer PPE
D. Handle HDs with supervision
Rationale: ASCO/ONS recommends alternative duties for pregnant nurses to protect
against HD exposure.
5. Which device enhances safety when administering hazardous drugs?
A. Open syringe system
B. Closed-system transfer device (CSTD)
C. Standard IV tubing
, 2
D. Non-vented syringe
Rationale: CSTDs prevent drug leakage and exposure, aligning with USP <800> safety
standards.
6. How long should HD precautions be maintained after chemotherapy administration?
A. 24 hours
B. 48 hours
C. 12 hours
D. 72 hours
Rationale: HD precautions are maintained for 48 hours due to potential excretion in
bodily fluids.
7. A nurse is handling HD-contaminated linens. Which action is appropriate?
A. Wash with regular laundry
B. Place in a designated HD waste container
C. Reuse after shaking out
D. Store in an open bin
Rationale: HD-contaminated linens must be disposed of in designated containers to
prevent exposure.
8. Which practice complies with NIOSH guidelines for HD storage?
A. Storing HDs with non-hazardous drugs
B. Storing HDs in a negative-pressure room
C. Keeping HDs in an open cabinet
D. Storing near a heat source
Rationale: NIOSH recommends negative-pressure storage to contain HDs and prevent
contamination.
9. A nurse is cleaning a surface contaminated with HDs. Which solution is appropriate?
A. Soap and water
B. EPA-registered disinfectant
C. Alcohol wipes
D. Warm water only
Rationale: An EPA-registered disinfectant effectively decontaminates HD residues per
USP <800>.
10. What should a nurse do if HD contacts their skin?
A. Wipe with a dry cloth
B. Wash with soap and water immediately
C. Apply an alcohol-based sanitizer
D. Ignore the exposure
Rationale: Immediate washing with soap and water removes HDs from the skin,
reducing exposure risk.
Infusion Protocols
11. A nurse is administering a vesicant chemotherapy agent. Which method is safest?
A. Short infusion over 2 hours
B. IV push via a free-flow method with close monitoring
C. Continuous infusion
ONS/ONCC Chemotherapy &
Immunotherapy Certificate Exam
2025/2026 – 50 Verified Questions with
Correct Answers
Hazardous Drug Handling
1. A nurse is preparing to administer a hazardous drug (HD). Which personal protective
equipment (PPE) is required per USP <800> standards?
A. Single pair of gloves
B. Two pairs of chemotherapy-tested gloves and a gown
C. Face mask only
D. Standard surgical gloves
Rationale: USP <800> requires two pairs of chemotherapy-tested gloves and a gown to
minimize exposure during HD handling.
2. A nurse accidentally spills a hazardous drug. What is the first action to take?
A. Wipe with a dry cloth
B. Use a spill kit with appropriate PPE
C. Flush with water
D. Continue working
Rationale: Using a spill kit with PPE ensures safe cleanup and prevents exposure to
hazardous drugs.
3. Which practice reduces hazardous drug exposure when disposing of patient waste?
A. Flushing the toilet with the lid up
B. Flushing with the lid down or using a plastic-backed pad
C. Disposing waste in regular trash
D. Handling waste without gloves
Rationale: Flushing with the lid down or using a plastic-backed pad minimizes
aerosolized HD contamination.
4. A nurse is pregnant. What does ASCO/ONS recommend regarding HD handling?
A. Continue handling HDs
B. Offer alternative duties to avoid exposure
C. Use single-layer PPE
D. Handle HDs with supervision
Rationale: ASCO/ONS recommends alternative duties for pregnant nurses to protect
against HD exposure.
5. Which device enhances safety when administering hazardous drugs?
A. Open syringe system
B. Closed-system transfer device (CSTD)
C. Standard IV tubing
, 2
D. Non-vented syringe
Rationale: CSTDs prevent drug leakage and exposure, aligning with USP <800> safety
standards.
6. How long should HD precautions be maintained after chemotherapy administration?
A. 24 hours
B. 48 hours
C. 12 hours
D. 72 hours
Rationale: HD precautions are maintained for 48 hours due to potential excretion in
bodily fluids.
7. A nurse is handling HD-contaminated linens. Which action is appropriate?
A. Wash with regular laundry
B. Place in a designated HD waste container
C. Reuse after shaking out
D. Store in an open bin
Rationale: HD-contaminated linens must be disposed of in designated containers to
prevent exposure.
8. Which practice complies with NIOSH guidelines for HD storage?
A. Storing HDs with non-hazardous drugs
B. Storing HDs in a negative-pressure room
C. Keeping HDs in an open cabinet
D. Storing near a heat source
Rationale: NIOSH recommends negative-pressure storage to contain HDs and prevent
contamination.
9. A nurse is cleaning a surface contaminated with HDs. Which solution is appropriate?
A. Soap and water
B. EPA-registered disinfectant
C. Alcohol wipes
D. Warm water only
Rationale: An EPA-registered disinfectant effectively decontaminates HD residues per
USP <800>.
10. What should a nurse do if HD contacts their skin?
A. Wipe with a dry cloth
B. Wash with soap and water immediately
C. Apply an alcohol-based sanitizer
D. Ignore the exposure
Rationale: Immediate washing with soap and water removes HDs from the skin,
reducing exposure risk.
Infusion Protocols
11. A nurse is administering a vesicant chemotherapy agent. Which method is safest?
A. Short infusion over 2 hours
B. IV push via a free-flow method with close monitoring
C. Continuous infusion
