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biochemie heem metabolisme

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biochemie heem metabolisme hoofdstuk 1

Institution
Universiteit Gent (UGent)
Course
Cardiovasculair stelsel ademhaling nier en urinewegen

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Cardiovasculair Stelsel
Biochemie
Heem metabolisme




1

,Inhoud

· IJzer
· Fe-bindende eiwitten
· Distributie
· Heem
· Structuur
· Synthese
· Biosynthetische enzymen
· Regulatie van synthese
· Katabolisme




2

, Hemoglobine: O2 transport in bloed
· 4 ketens met elk 1 heem
groep
· “switch” van fetaal (HbF)
naar adult (HbA)
hemoglobine tijdens
ontwikkeling:

Stadium Ketens Naam
Embryonaal ζ2 ε2 HbE-Gower-1
ζ2 γ 2 HbE-Portland-1
Fetaal α2 γ 2 HbF


Adult α2 β 2 HbA 1
α2 δ 2 HbA 2 (<2%)




Foetus moet grotere heem a niteit hebben omdat hij O2 moet opnemen uit placenta en de pO2 is daar veel lager

Switch kan complicaties vertonen




3

ffi

, O2 bindt aan heem in hemoglobine via ijzer




deoxyhemoglobine oxyhemoglobine
IJzer:
- Wordt niet actief geëxcreteerd
- Terug te vinden in verschillende oxidatietoestanden, vnl. Fe 2+ en Fe 3+, (Fe 4+ en
Fe 6+ ook mogelijk in katalytische intermediairen)




Centraal Fe atoom heel belangrijk
Geen excretie van Fe




4
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Course
Cardiovasculair stelsel ademhaling nier en urinewegen
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Uploaded on
July 12, 2025
Number of pages
34
Written in
2021/2022
Type
Class notes
Professor(s)
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Subjects

  • biochemie
  • heem
  • metabolisme
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