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Addisons ds primary adrenal insuffciency. rare. caused by destroyed layers of adrenal
cortex--> dec cortisol. autoimmune
signs and symptoms of addisons ds bronze skin, dec bg, change in body hair, weight dec
secondary adrenal insufficiency damage to the pituitary gland causing hypocortisolism
acute adrenal crisis Life-threatening, can be caused by illness in someone with Addison's
disease
Manifestations- N/V, muscular weakness, hypotension, dehydration, and vascular collapse
Treatment- fluids both NS and D5W, glucocorticoid replacement therapy
s/s adrenal corticol insuffienciency anorexia, weight loss, fatigue, myalgia, n/v, orthostatic
hypotension, dec NA, inc K, hyperpigmentation, hypoglycemia
treatment for addisons lifelong therapy with mineral corticoids
addisons syndrome hypocortisol because pf exogenous corticosteroids and adrenal needs to
wake up
cushings ds hypercortisol for any reason.
s/s cushings syndrome moon face, buffalo hump, msucle weakness, purple striae,
osteoporosis, dec K, hirstuism, mild acne
, ectopic form of cushings ds non-pituitary ACTH secreting tumor
dexamethosone supression test diagnose cushings ds
glucose brain and NS rely specifically on as a fuel source. 4k/cal
glycogenolysis glycogen is broken down, glucose is released
gluconeogensis liver synthesizes glucose from amnio acids, glycerol, and lactic acid. released
into circulation and stored as glycogen
fat 9 k/cal. cannot convert to glucose
fatty acids almost all cells except the brain, NS, and RBCs can use interchangeablly with
glucose
ketones degraded by fatty acids in the liver
acini secrete digestive juices into duodenum
the islets of langerhans secrete hormones into the blood. composed of beta cells, alpha
cells, delta cells
beta cells secrete insulin
alpha cells secrete glucagon
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Addisons ds primary adrenal insuffciency. rare. caused by destroyed layers of adrenal
cortex--> dec cortisol. autoimmune
signs and symptoms of addisons ds bronze skin, dec bg, change in body hair, weight dec
secondary adrenal insufficiency damage to the pituitary gland causing hypocortisolism
acute adrenal crisis Life-threatening, can be caused by illness in someone with Addison's
disease
Manifestations- N/V, muscular weakness, hypotension, dehydration, and vascular collapse
Treatment- fluids both NS and D5W, glucocorticoid replacement therapy
s/s adrenal corticol insuffienciency anorexia, weight loss, fatigue, myalgia, n/v, orthostatic
hypotension, dec NA, inc K, hyperpigmentation, hypoglycemia
treatment for addisons lifelong therapy with mineral corticoids
addisons syndrome hypocortisol because pf exogenous corticosteroids and adrenal needs to
wake up
cushings ds hypercortisol for any reason.
s/s cushings syndrome moon face, buffalo hump, msucle weakness, purple striae,
osteoporosis, dec K, hirstuism, mild acne
, ectopic form of cushings ds non-pituitary ACTH secreting tumor
dexamethosone supression test diagnose cushings ds
glucose brain and NS rely specifically on as a fuel source. 4k/cal
glycogenolysis glycogen is broken down, glucose is released
gluconeogensis liver synthesizes glucose from amnio acids, glycerol, and lactic acid. released
into circulation and stored as glycogen
fat 9 k/cal. cannot convert to glucose
fatty acids almost all cells except the brain, NS, and RBCs can use interchangeablly with
glucose
ketones degraded by fatty acids in the liver
acini secrete digestive juices into duodenum
the islets of langerhans secrete hormones into the blood. composed of beta cells, alpha
cells, delta cells
beta cells secrete insulin
alpha cells secrete glucagon