,Test Bank For Cellular and Molecular
Immunology, 10th Edition (Abbas, 2022),
Chapter 1-21 | All Chapters Questions And
Correct Answers (Verified Answers) Plus
Rationales 2025 Q&A | Instant Download PDF
1. Which cell type is primarily responsible for initiating adaptive immune
responses?
A) NK cells
B) Macrophages
C) Dendritic cells
D) Neutrophils
Dendritic cells capture antigens and present them to naïve T cells,
initiating adaptive immunity.
2. Which cytokine is crucial for Th1 cell differentiation?
A) IL-4
B) IL-12
C) IL-10
D) TGF-β
, IL-12 produced by dendritic cells and macrophages promotes Th1
differentiation.
3. Which antibody class is predominant in mucosal secretions?
A) IgG
B) IgM
C) IgE
D) IgA
IgA is the main immunoglobulin found in mucosal areas and
secretions like saliva and tears.
4. What is the function of perforin released by cytotoxic T lymphocytes?
A) Activate complement
B) Form pores in target cell membranes
C) Promote B cell class switching
D) Stimulate NK cells
Perforin forms pores that allow granzymes to enter and induce
apoptosis in infected cells.
5. Which molecule on antigen-presenting cells provides costimulatory
signals to T cells?
A) MHC II
B) CD4
C) B7 (CD80/CD86)
D) ICAM-1
B7 binds to CD28 on T cells to deliver necessary costimulatory signals.
, 6. Which complement pathway is antibody-dependent?
A) Lectin
B) Alternative
C) Classical
D) Terminal
The classical pathway is initiated by antigen-antibody complexes.
7. The main transcription factor activated by TLR signaling is:
A) STAT6
B) NF-κB
C) IRF3
D) c-Fos
NF-κB activation leads to production of pro-inflammatory cytokines.
8. Which cytokine promotes isotype switching to IgE?
A) IL-2
B) IL-4
C) IL-12
D) IFN-γ
IL-4 drives class switching to IgE, important in allergic responses.
9. Which enzyme is required for somatic hypermutation?
A) DNA polymerase
B) RAG1/2
C) AID (Activation-Induced Cytidine Deaminase)
Immunology, 10th Edition (Abbas, 2022),
Chapter 1-21 | All Chapters Questions And
Correct Answers (Verified Answers) Plus
Rationales 2025 Q&A | Instant Download PDF
1. Which cell type is primarily responsible for initiating adaptive immune
responses?
A) NK cells
B) Macrophages
C) Dendritic cells
D) Neutrophils
Dendritic cells capture antigens and present them to naïve T cells,
initiating adaptive immunity.
2. Which cytokine is crucial for Th1 cell differentiation?
A) IL-4
B) IL-12
C) IL-10
D) TGF-β
, IL-12 produced by dendritic cells and macrophages promotes Th1
differentiation.
3. Which antibody class is predominant in mucosal secretions?
A) IgG
B) IgM
C) IgE
D) IgA
IgA is the main immunoglobulin found in mucosal areas and
secretions like saliva and tears.
4. What is the function of perforin released by cytotoxic T lymphocytes?
A) Activate complement
B) Form pores in target cell membranes
C) Promote B cell class switching
D) Stimulate NK cells
Perforin forms pores that allow granzymes to enter and induce
apoptosis in infected cells.
5. Which molecule on antigen-presenting cells provides costimulatory
signals to T cells?
A) MHC II
B) CD4
C) B7 (CD80/CD86)
D) ICAM-1
B7 binds to CD28 on T cells to deliver necessary costimulatory signals.
, 6. Which complement pathway is antibody-dependent?
A) Lectin
B) Alternative
C) Classical
D) Terminal
The classical pathway is initiated by antigen-antibody complexes.
7. The main transcription factor activated by TLR signaling is:
A) STAT6
B) NF-κB
C) IRF3
D) c-Fos
NF-κB activation leads to production of pro-inflammatory cytokines.
8. Which cytokine promotes isotype switching to IgE?
A) IL-2
B) IL-4
C) IL-12
D) IFN-γ
IL-4 drives class switching to IgE, important in allergic responses.
9. Which enzyme is required for somatic hypermutation?
A) DNA polymerase
B) RAG1/2
C) AID (Activation-Induced Cytidine Deaminase)
