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Samenvatting gen- en celtechnologie: les 5 basis celcultuur; secretome: EVs

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(Behaalde score: 17/20) Deze samenvatting bevat alle info uit de slides, inclusief figuren en uitleg van de prof.

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Universiteit Gent (UGent)
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Gen en celtechnologie (D013087A)








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Institution
Universiteit Gent (UGent)
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Biomedische Wetenschappen
Course
Gen en celtechnologie (D013087A)
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Uploaded on
July 7, 2025
Number of pages
2
Written in
2024/2025
Type
Summary

Subjects

  • gen en celtechnologie
  • biomedische wetenschapppen
  • ugent
  • samenvatting
  • universiteit gent

Content preview

Les 5: basis celcultuur; secretome: EVs
Extracellulaire vesikels
 Is prof haar passie 😉


• Elektronenmicroscopisch beeld:
o Dubbele lipidelagen (zelfde structuur als membraanwand)
o Grootte is variabel (50nm- paar µm)
o Dens geladen of niet dens geladen

➔ heterogeniteit aan vesikels




• Functie
o Naast afvalvat ook heel belangrijk communicatiemiddel
▪ Gedrag van cellen in naburig weefsel beïnvloeden, maar ook weefsels op
afstand
▪ Uitscheiding van overtollig materiaal dat mogelijk schadelijk zou kunnen zijn
voor cel; kankercellen in tumorweefsels stellen bv EVs vrij:
➢ Kan in circulatie terecht komen
➢ Hebben enzymatische activiteit
➢ Lokale matrix modificeren en zo metastase stimuleren
o Representatief voor inhoud van de cel
o Spelen ook rol in immuunsysteem
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