1
CDE Practice Exam 2 2025/2026 Exam
Questions Marking Scheme New Update
| A+ Rated
CJ is a 19 year old who is contemplating obtaining a CGM. You tell him that, if
used regularly, the major advantage of wearing a CGM device would be:
A. fewer episodes of hypo- and hyperglycemia
B. finger sticks would not be required except to calibrate
C. lower A1Cs
D. less insulin would be required - 🧠 ANSWER ✔✔A. fewer episodes of hypo-
and hyperglycemia
Which of the following islet cell antibodies is the best immunologic predictor of
T1DM?
A. Glutamic acid decarboxylase (GAD)
B. Heat shock protein 65
C. Peripherin
1
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,2
D. Endocrine cell antigens - 🧠 ANSWER ✔✔A. Glutamic acid decarboxylase
(GAD)
A thin 38 year old female presents to the clinic for evaluation of her glycemic
control. She was diagnosed with diabetes 9 months ago with an A1C of 13% and
started on metformin and glipizide. Three months later her glycemic control was
much improved (A1C of 7.4%), but today she reports increased thirst and
urination. Her A1C today is 11.2% despite confirmed adherence with her
medications and a negative pregnancy test. Which of the following is the MOST
likely diagnosis?
A. T1DM
B. T2DM
C. Latent autoimmune diabetes of adults (LADA)
D. Gestational diabetes (GDM) - 🧠 ANSWER ✔✔C. Latent autoimmune diabetes
of adults (LADA)
Patients with LADA are typically less than 40 years of age and often misdiagnosed
with T2DM at presentation. Because those patients typically respond initially to
oral agents and do not require insulin, they are not usually diagnosed with T1DM.
2
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STATEMENT. ALL RIGHTS RESERVED
,3
However, these patients usually progress to insulin requirement over a period of
several months, leading some experts to consider LADA related to T1DM.
The development of T1DM includes all of the following except a/an:
A. environmental trigger
B. genetic predisposition
C. autoimmune attack on beta cells
D. peripheral insulin resistance - 🧠 ANSWER ✔✔D. peripheral insulin resistance
The pathophysiological stages in the development of T1DM include a genetic
predisposition (stage 1), an environmental trigger (stage 2), and active
autoimmunity (stage 3). Peripheral insulin resistance is a defect seen in T2DM.
JT, a 34 year old male with newly diagnosed T1DM and HTN, states that he has an
occasional alcoholic drink and wants to know if alcohol is allowed. Which of the
following is the MOST appropriate response?
A. Yes, but always consume alcohol with food to minimize the risk of nocturnal
hypoglycemia
B. It is recommended to drink 2 glasses of red wine every day to reduce the risk of
cardiovascular disease
3
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STATEMENT. ALL RIGHTS RESERVED
, 4
C. Yes, but substitute an alcoholic drink for 1 carb serving
D. No, alcoholic beverages should be avoided in persons with HTN due to the
impact on the BP - 🧠 ANSWER ✔✔A. Yes, but always consume alcohol with food
to minimize the risk of nocturnal hypoglycemia
A 45 year old man presents for a 1 month f/u after starting immediate release
metformin 500 mg twice daily. Today he brought in his bg meter and bottle of
metformin, which is nearly full. Which of the following is the MOST appropriate
next step to evaluate his adherence to the regimen?
A. Confront the patent about his noncompliance
B. Telephone the pharmacy to verify the last refill date
C. Change to the extended release formulation of metformin
D. Review self-monitored bg log - 🧠 ANSWER ✔✔B. Telephone the pharmacy to
verify the last refill date
The provider suspects poor adherence with this patient, but needs to confirm with
additional information. Confronting the patient will likely only result in denial.
Additional questioning of the patient may reveal intolerable side effects, but
changing the metformin formulation is premature at this point. Review of the self
monitored bg log is important, but will confirm the suspected poor adherence.
4
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED
CDE Practice Exam 2 2025/2026 Exam
Questions Marking Scheme New Update
| A+ Rated
CJ is a 19 year old who is contemplating obtaining a CGM. You tell him that, if
used regularly, the major advantage of wearing a CGM device would be:
A. fewer episodes of hypo- and hyperglycemia
B. finger sticks would not be required except to calibrate
C. lower A1Cs
D. less insulin would be required - 🧠 ANSWER ✔✔A. fewer episodes of hypo-
and hyperglycemia
Which of the following islet cell antibodies is the best immunologic predictor of
T1DM?
A. Glutamic acid decarboxylase (GAD)
B. Heat shock protein 65
C. Peripherin
1
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED
,2
D. Endocrine cell antigens - 🧠 ANSWER ✔✔A. Glutamic acid decarboxylase
(GAD)
A thin 38 year old female presents to the clinic for evaluation of her glycemic
control. She was diagnosed with diabetes 9 months ago with an A1C of 13% and
started on metformin and glipizide. Three months later her glycemic control was
much improved (A1C of 7.4%), but today she reports increased thirst and
urination. Her A1C today is 11.2% despite confirmed adherence with her
medications and a negative pregnancy test. Which of the following is the MOST
likely diagnosis?
A. T1DM
B. T2DM
C. Latent autoimmune diabetes of adults (LADA)
D. Gestational diabetes (GDM) - 🧠 ANSWER ✔✔C. Latent autoimmune diabetes
of adults (LADA)
Patients with LADA are typically less than 40 years of age and often misdiagnosed
with T2DM at presentation. Because those patients typically respond initially to
oral agents and do not require insulin, they are not usually diagnosed with T1DM.
2
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED
,3
However, these patients usually progress to insulin requirement over a period of
several months, leading some experts to consider LADA related to T1DM.
The development of T1DM includes all of the following except a/an:
A. environmental trigger
B. genetic predisposition
C. autoimmune attack on beta cells
D. peripheral insulin resistance - 🧠 ANSWER ✔✔D. peripheral insulin resistance
The pathophysiological stages in the development of T1DM include a genetic
predisposition (stage 1), an environmental trigger (stage 2), and active
autoimmunity (stage 3). Peripheral insulin resistance is a defect seen in T2DM.
JT, a 34 year old male with newly diagnosed T1DM and HTN, states that he has an
occasional alcoholic drink and wants to know if alcohol is allowed. Which of the
following is the MOST appropriate response?
A. Yes, but always consume alcohol with food to minimize the risk of nocturnal
hypoglycemia
B. It is recommended to drink 2 glasses of red wine every day to reduce the risk of
cardiovascular disease
3
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED
, 4
C. Yes, but substitute an alcoholic drink for 1 carb serving
D. No, alcoholic beverages should be avoided in persons with HTN due to the
impact on the BP - 🧠 ANSWER ✔✔A. Yes, but always consume alcohol with food
to minimize the risk of nocturnal hypoglycemia
A 45 year old man presents for a 1 month f/u after starting immediate release
metformin 500 mg twice daily. Today he brought in his bg meter and bottle of
metformin, which is nearly full. Which of the following is the MOST appropriate
next step to evaluate his adherence to the regimen?
A. Confront the patent about his noncompliance
B. Telephone the pharmacy to verify the last refill date
C. Change to the extended release formulation of metformin
D. Review self-monitored bg log - 🧠 ANSWER ✔✔B. Telephone the pharmacy to
verify the last refill date
The provider suspects poor adherence with this patient, but needs to confirm with
additional information. Confronting the patient will likely only result in denial.
Additional questioning of the patient may reveal intolerable side effects, but
changing the metformin formulation is premature at this point. Review of the self
monitored bg log is important, but will confirm the suspected poor adherence.
4
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED
