TEST BANK FOR
g g
Immunology gand gSerology gin gLaboratory gMedicine, g7th gEdition gby gMary gLouise gTurgeon
Chapter g1-27
Chapter g01: gHighlights gof gthe gInnate gand gAdaptive gImmune gSystems
MULTIPLE gCHOICE
1. The g―father‖ gof gimmunology gis ggenerally gconsidered gto gbe
a. Koch.
b. Pasteur.
c. Gram.
d. Salk.
ANS: g B
Louis gPasteur gis ggenerally gconsidered gto gbe gthe g―father gof gimmunology.‖
DIF: Cognitive gLevel: gI
2. An gearly gform gof gimmunization gwas gpracticed gby gthe
a. Romans.
b. Greeks.
c. Chinese.
d. Native gAmericans.
ANS: g C
Beginning gabout g1000 gAD, gthe gChinese gpracticed ga gform gof gimmunization gby ginhaling gdried
gpowders gderived gfrom gthe gcrusts gof gsmallpox glesions.
DIF: Cognitive gLevel: gI
3. A gspecific gfunction gof gthe gimmune gsystem gis gto
a. recognize gself gfrom gnonself.
b. defend gthe gbody gagainst gnonself.
c. amplify gspecific gfunctions.
d. Both gA gand gB.
ANS: g D
The gfunction gof gthe gimmune gsystem gis gto grecognize gself gfrom gnonself gand gdefend gthe gbody
gagainst gnonself. gSuch ga gsystem gis gnecessary gfor gsurvival. gThe gimmune gsystem galso ghas
gnonspecific geffector gmechanisms gthat gusually gamplify gthe gspecific gfunctions. gNonspecific
gcomponents gof gthe gimmune gsystem ginclude gmononuclear gphagocytes, gpolymorphonuclear
gleukocytes, gand gsoluble gfactors g(e.g., gcomplement).
DIF: Cognitive gLevel: gI
4. An gundesirable gconsequence gof gimmunity gis
a. natural gresistance.
b. acquired gresistance gto ginfectious gdiseases.
PlusBay.Plus
, c. an gautoimmune gdisorder.
d. recovery gfrom ginfectious gdisease.
ANS: g C
The gdesirable gconsequences gof gimmunity ginclude gnatural gresistance, grecovery, gand gacquired
gresistance gto ginfectious gdiseases. gA gdeficiency gor gdysfunction gof gthe gimmune gsystem gcan
gcause gmany gdisorders. gUndesirable gconsequences gof gimmunity ginclude gallergy, grejection gof
ga gtransplanted gorgan, gor gan gautoimmune gdisorder.
DIF: Cognitive gLevel: gI
5. The gimmune gsystem ghas gvarious gdistinctive gcharacteristics gexcept;
a. specificity.
b. memory.
c. mobility.
d. noncooperation gamong gdifferent gcells.
ANS: g D
The gimmune gsystem gis gcomposed gof ga glarge, gcomplex gset gof gwidely gdistributed gelements,
gwith gthe gdistinctive gcharacteristics gof gspecificity, gmemory, gmobility, greplicability, gand
gcooperation gamong gdifferent gcells gor gcellular gproducts. gSpecificity gand gmemory gare
gcharacteristics gof glymphocytes gin gthe gimmune gsystem. gNonspecific gelements gof gthe gimmune
gsystem gdemonstrate gmobility. gIn gaddition, gspecific gand gnonspecific gcellular gcomponents gof
gthe gimmune gsystem gcan greplicate. gCooperation gis grequired gfor goptimal gfunctioning, gand
ginteraction ginvolves gspecific gcellular gelements, gcell gproducts, gand gnonlymphoid gelements.
DIF: Cognitive gLevel: gI
6. Hematopoiesis goccurs gin gthe gyolk gsac gduring gthe
a. immediate ghours gafter gconception
b. second gmonth gof ggestation.
c. second gtrimester gof ggestation.
d. periods gof gsevere ganemia gin gchildren.
ANS: g A
The gsites gof gblood gcell gdevelopment, gor ghematopoiesis, gfollow ga gdefinite gsequence gin gthe
gembryo gand gfetus. gHematopoiesis goccurs gin gthe gyolk gsac gduring gthe gsecond gmonth gof
ggestation.
DIF: Cognitive gLevel: gII
7. The gsequence gof gblood gcell gdevelopment gin gthe gembryo gand gfetus gis
a. yolk gsac, gliver-spleen, gbone gmarrow.
b. yolk gsac, gbone gmarrow, gliver/spleen.
c. liver-spleen, gyolk gsac, gbone gmarrow.
d. bone gmarrow, gliver-spleen, gyolk gsac.
ANS: g A
PlusBay.Plus
, The gfirst gblood gcells gare gprimitive gred gblood gcells g(erythroblasts; gRBCs) gformed gin gthe
gislets gof gthe gyolk gsac gduring gthe gfirst g2 gto g8 gweeks gof glife. gGradually, gthe gliver gand gspleen
greplace gthe gyolk gsac gas gthe gsites gof gblood gcell gdevelopment. gBy gthe gsecond gmonth gof
ggestation, gthe gliver gbecomes gthe gmajor gsite gof ghematopoiesis, gand ggranular gtypes gof
gleukocytes ghave gmade gtheir ginitial gappearance. gThe gliver gand gspleen gpredominate gfrom
gabout g2 gto g5 gmonths gof gfetal glife. gIn gthe gfourth gmonth gof ggestation, gbone gmarrow gbegins
gto gproduce gblood gcells. gAfter gthe gfifth gfetal gmonth, gbone gmarrow gbegins gto gassume gits
gultimate grole gas gthe gprimary gsite gof ghematopoiesis.
DIF: Cognitive gLevel: gII
8. The gprimary gfunction gof gmature gneutrophils gis
a. to greduce ginflammation.
b. to glyse gparasites gin gthe gcirculatory gsystem.
c. antigen grecognition.
d. phagocytosis.
ANS: g D
Various gphagocytic gcells gcontinually gcirculate gthroughout gthe gblood, glymph, ggastrointestinal
gsystem, gand grespiratory gtract. gWhen gtrauma goccurs, gthe gneutrophils garrive gat gthe gsite gof
ginjury gand gcan gbe gfound gin gthe ginitial gexudate gin gless gthan g1 ghour. gMonocytes gare gslower
gin gmoving gto gthe ginflammatory gsite. gMacrophages gresident gin gthe gtissues gof gthe gbody gare
galready gin gplace gto gdeal gwith gan gintruding gagent. gAdditional gmacrophages gfrom gthe gbone
gmarrow gand gother gtissues gcan gbe greleased gin gsevere ginfections.
DIF: Cognitive gLevel: gII
9. Primary ggranules, gor gazurophilic ggranules, gin gneutrophils gcontain
a. lysozyme.
b. myeloperoxidase.
c. lactoferrin.
d. Both gA gand gB.
ANS: g D
Granules gin gthe gphagocyte gcytosol gcontain gdegradatory genzymes gof gthree gtypes
1. Primary, gor gazurophilic, ggranules gcontaining genzymes g(e.g.,
glysozyme, gmyeloperoxidase)
2. Secondary, gor gspecific, ggranules gcontaining gsubstances gsuch gas glactoferrin.
3. Tertiary ggranules gcontaining gsubstances gsuch gas gcaspases
DIF: Cognitive gLevel: gI
10. The gorigin gof ga gcondition gwhen geosinophils gare gincreased gin gthe gcirculating gblood gis
gassociated gwith:
a. fungus
b. parasitic gamoeba
c. allergic greactions
d. bacteria
ANS: g C
PlusBay.Plus
, An gincrease gin geosinophils gis gassociated gwith ga gwide gvariety gof gconditions, gbut gespecially
gwith gallergic greactions, gdrug greactions, gcertain gskin gdisorders, gparasitic ginfestations,
gcollagen gvascular gdiseases, gHodgkin gdisease, gand gmyeloproliferative gdiseases.
A gfunctional gproperty grelated gto gthe gmembrane greceptors gof gthe geosinophil gis gthe gcell’s
gability gto ginteract gwith gthe glarval gstages gof gsome ghelminth gparasites gand gdamage gthem gby
goxidative gmechanisms. gCertain gproteins greleased gfrom geosinophilic ggranules gdamage
gantibody-coated gSchistosoma gparasites gand gmay gaccount gfor gdamage gto gendothelial gcells
gin ghypereosinophilic gsyndromes.
DIF: Cognitive gLevel: gI
11. A gbasophil gdegranulates gin ga(n)
a. inflammatory greaction.
b. immediate g(acute) ghypersensitivity greaction.
c. chronic gtissue grejection.
d. Both gA gand gB.
ANS: g B
Basophils ghave ghigh gconcentrations gof gheparin gand ghistamine gin gtheir ggranules. gIf gevents
gare gtriggered gby gantigens gfrom gpollen, gfood, gdrugs, gor ginsect gvenom, gthe gresult gis gan
gimmediate ghypersensitivity greaction.
DIF: Cognitive gLevel: gII
12. Mononuclear gcells gare geffective gphagocytic gcells gagainst
a. staphylococci.
b. streptococci.
c. Mycobacterium gtuberculosis.
d. pneumonia.
ANS: g C
Mononuclear gcells gare gparticularly geffective gas gphagocytic gcells gbecause gof gthe glarge
gamounts gof glipase gin gtheir gcytoplasm. gLipase gis gable gto gattack gbacteria gwith ga glipid
gcapsule, gsuch gas gMycobacterium gtuberculosis.
DIF: Cognitive gLevel: gI
13. Macrophages
a. process gantigens.
b. physically gpresent gbiologically gmodified gantigens gto glymphocytes.
c. secrete ga glymphocyte-activating gfactor g(IL-1) gas ga gresult gof gproper
g MHC grecognition.
d. All gof gthe gabove.
ANS: g D
The gphagocytic gproperty gof gthe gmacrophage gis gparticularly gimportant gin gthe gprocessing gof
gantigens gas gpart gof gthe gimmune gresponse. gMacrophages gare gbelieved gto gprocess gantigens
gand gphysically gpresent gthis gbiochemically gmodified gand gmore greactive gform gof gantigen gto
glymphocytes g(particularly gT ghelper gcells) gas gan ginitial gstep gin gthe gimmune gresponse.
DIF: Cognitive gLevel: gII
PlusBay.Plus
g g
Immunology gand gSerology gin gLaboratory gMedicine, g7th gEdition gby gMary gLouise gTurgeon
Chapter g1-27
Chapter g01: gHighlights gof gthe gInnate gand gAdaptive gImmune gSystems
MULTIPLE gCHOICE
1. The g―father‖ gof gimmunology gis ggenerally gconsidered gto gbe
a. Koch.
b. Pasteur.
c. Gram.
d. Salk.
ANS: g B
Louis gPasteur gis ggenerally gconsidered gto gbe gthe g―father gof gimmunology.‖
DIF: Cognitive gLevel: gI
2. An gearly gform gof gimmunization gwas gpracticed gby gthe
a. Romans.
b. Greeks.
c. Chinese.
d. Native gAmericans.
ANS: g C
Beginning gabout g1000 gAD, gthe gChinese gpracticed ga gform gof gimmunization gby ginhaling gdried
gpowders gderived gfrom gthe gcrusts gof gsmallpox glesions.
DIF: Cognitive gLevel: gI
3. A gspecific gfunction gof gthe gimmune gsystem gis gto
a. recognize gself gfrom gnonself.
b. defend gthe gbody gagainst gnonself.
c. amplify gspecific gfunctions.
d. Both gA gand gB.
ANS: g D
The gfunction gof gthe gimmune gsystem gis gto grecognize gself gfrom gnonself gand gdefend gthe gbody
gagainst gnonself. gSuch ga gsystem gis gnecessary gfor gsurvival. gThe gimmune gsystem galso ghas
gnonspecific geffector gmechanisms gthat gusually gamplify gthe gspecific gfunctions. gNonspecific
gcomponents gof gthe gimmune gsystem ginclude gmononuclear gphagocytes, gpolymorphonuclear
gleukocytes, gand gsoluble gfactors g(e.g., gcomplement).
DIF: Cognitive gLevel: gI
4. An gundesirable gconsequence gof gimmunity gis
a. natural gresistance.
b. acquired gresistance gto ginfectious gdiseases.
PlusBay.Plus
, c. an gautoimmune gdisorder.
d. recovery gfrom ginfectious gdisease.
ANS: g C
The gdesirable gconsequences gof gimmunity ginclude gnatural gresistance, grecovery, gand gacquired
gresistance gto ginfectious gdiseases. gA gdeficiency gor gdysfunction gof gthe gimmune gsystem gcan
gcause gmany gdisorders. gUndesirable gconsequences gof gimmunity ginclude gallergy, grejection gof
ga gtransplanted gorgan, gor gan gautoimmune gdisorder.
DIF: Cognitive gLevel: gI
5. The gimmune gsystem ghas gvarious gdistinctive gcharacteristics gexcept;
a. specificity.
b. memory.
c. mobility.
d. noncooperation gamong gdifferent gcells.
ANS: g D
The gimmune gsystem gis gcomposed gof ga glarge, gcomplex gset gof gwidely gdistributed gelements,
gwith gthe gdistinctive gcharacteristics gof gspecificity, gmemory, gmobility, greplicability, gand
gcooperation gamong gdifferent gcells gor gcellular gproducts. gSpecificity gand gmemory gare
gcharacteristics gof glymphocytes gin gthe gimmune gsystem. gNonspecific gelements gof gthe gimmune
gsystem gdemonstrate gmobility. gIn gaddition, gspecific gand gnonspecific gcellular gcomponents gof
gthe gimmune gsystem gcan greplicate. gCooperation gis grequired gfor goptimal gfunctioning, gand
ginteraction ginvolves gspecific gcellular gelements, gcell gproducts, gand gnonlymphoid gelements.
DIF: Cognitive gLevel: gI
6. Hematopoiesis goccurs gin gthe gyolk gsac gduring gthe
a. immediate ghours gafter gconception
b. second gmonth gof ggestation.
c. second gtrimester gof ggestation.
d. periods gof gsevere ganemia gin gchildren.
ANS: g A
The gsites gof gblood gcell gdevelopment, gor ghematopoiesis, gfollow ga gdefinite gsequence gin gthe
gembryo gand gfetus. gHematopoiesis goccurs gin gthe gyolk gsac gduring gthe gsecond gmonth gof
ggestation.
DIF: Cognitive gLevel: gII
7. The gsequence gof gblood gcell gdevelopment gin gthe gembryo gand gfetus gis
a. yolk gsac, gliver-spleen, gbone gmarrow.
b. yolk gsac, gbone gmarrow, gliver/spleen.
c. liver-spleen, gyolk gsac, gbone gmarrow.
d. bone gmarrow, gliver-spleen, gyolk gsac.
ANS: g A
PlusBay.Plus
, The gfirst gblood gcells gare gprimitive gred gblood gcells g(erythroblasts; gRBCs) gformed gin gthe
gislets gof gthe gyolk gsac gduring gthe gfirst g2 gto g8 gweeks gof glife. gGradually, gthe gliver gand gspleen
greplace gthe gyolk gsac gas gthe gsites gof gblood gcell gdevelopment. gBy gthe gsecond gmonth gof
ggestation, gthe gliver gbecomes gthe gmajor gsite gof ghematopoiesis, gand ggranular gtypes gof
gleukocytes ghave gmade gtheir ginitial gappearance. gThe gliver gand gspleen gpredominate gfrom
gabout g2 gto g5 gmonths gof gfetal glife. gIn gthe gfourth gmonth gof ggestation, gbone gmarrow gbegins
gto gproduce gblood gcells. gAfter gthe gfifth gfetal gmonth, gbone gmarrow gbegins gto gassume gits
gultimate grole gas gthe gprimary gsite gof ghematopoiesis.
DIF: Cognitive gLevel: gII
8. The gprimary gfunction gof gmature gneutrophils gis
a. to greduce ginflammation.
b. to glyse gparasites gin gthe gcirculatory gsystem.
c. antigen grecognition.
d. phagocytosis.
ANS: g D
Various gphagocytic gcells gcontinually gcirculate gthroughout gthe gblood, glymph, ggastrointestinal
gsystem, gand grespiratory gtract. gWhen gtrauma goccurs, gthe gneutrophils garrive gat gthe gsite gof
ginjury gand gcan gbe gfound gin gthe ginitial gexudate gin gless gthan g1 ghour. gMonocytes gare gslower
gin gmoving gto gthe ginflammatory gsite. gMacrophages gresident gin gthe gtissues gof gthe gbody gare
galready gin gplace gto gdeal gwith gan gintruding gagent. gAdditional gmacrophages gfrom gthe gbone
gmarrow gand gother gtissues gcan gbe greleased gin gsevere ginfections.
DIF: Cognitive gLevel: gII
9. Primary ggranules, gor gazurophilic ggranules, gin gneutrophils gcontain
a. lysozyme.
b. myeloperoxidase.
c. lactoferrin.
d. Both gA gand gB.
ANS: g D
Granules gin gthe gphagocyte gcytosol gcontain gdegradatory genzymes gof gthree gtypes
1. Primary, gor gazurophilic, ggranules gcontaining genzymes g(e.g.,
glysozyme, gmyeloperoxidase)
2. Secondary, gor gspecific, ggranules gcontaining gsubstances gsuch gas glactoferrin.
3. Tertiary ggranules gcontaining gsubstances gsuch gas gcaspases
DIF: Cognitive gLevel: gI
10. The gorigin gof ga gcondition gwhen geosinophils gare gincreased gin gthe gcirculating gblood gis
gassociated gwith:
a. fungus
b. parasitic gamoeba
c. allergic greactions
d. bacteria
ANS: g C
PlusBay.Plus
, An gincrease gin geosinophils gis gassociated gwith ga gwide gvariety gof gconditions, gbut gespecially
gwith gallergic greactions, gdrug greactions, gcertain gskin gdisorders, gparasitic ginfestations,
gcollagen gvascular gdiseases, gHodgkin gdisease, gand gmyeloproliferative gdiseases.
A gfunctional gproperty grelated gto gthe gmembrane greceptors gof gthe geosinophil gis gthe gcell’s
gability gto ginteract gwith gthe glarval gstages gof gsome ghelminth gparasites gand gdamage gthem gby
goxidative gmechanisms. gCertain gproteins greleased gfrom geosinophilic ggranules gdamage
gantibody-coated gSchistosoma gparasites gand gmay gaccount gfor gdamage gto gendothelial gcells
gin ghypereosinophilic gsyndromes.
DIF: Cognitive gLevel: gI
11. A gbasophil gdegranulates gin ga(n)
a. inflammatory greaction.
b. immediate g(acute) ghypersensitivity greaction.
c. chronic gtissue grejection.
d. Both gA gand gB.
ANS: g B
Basophils ghave ghigh gconcentrations gof gheparin gand ghistamine gin gtheir ggranules. gIf gevents
gare gtriggered gby gantigens gfrom gpollen, gfood, gdrugs, gor ginsect gvenom, gthe gresult gis gan
gimmediate ghypersensitivity greaction.
DIF: Cognitive gLevel: gII
12. Mononuclear gcells gare geffective gphagocytic gcells gagainst
a. staphylococci.
b. streptococci.
c. Mycobacterium gtuberculosis.
d. pneumonia.
ANS: g C
Mononuclear gcells gare gparticularly geffective gas gphagocytic gcells gbecause gof gthe glarge
gamounts gof glipase gin gtheir gcytoplasm. gLipase gis gable gto gattack gbacteria gwith ga glipid
gcapsule, gsuch gas gMycobacterium gtuberculosis.
DIF: Cognitive gLevel: gI
13. Macrophages
a. process gantigens.
b. physically gpresent gbiologically gmodified gantigens gto glymphocytes.
c. secrete ga glymphocyte-activating gfactor g(IL-1) gas ga gresult gof gproper
g MHC grecognition.
d. All gof gthe gabove.
ANS: g D
The gphagocytic gproperty gof gthe gmacrophage gis gparticularly gimportant gin gthe gprocessing gof
gantigens gas gpart gof gthe gimmune gresponse. gMacrophages gare gbelieved gto gprocess gantigens
gand gphysically gpresent gthis gbiochemically gmodified gand gmore greactive gform gof gantigen gto
glymphocytes g(particularly gT ghelper gcells) gas gan ginitial gstep gin gthe gimmune gresponse.
DIF: Cognitive gLevel: gII
PlusBay.Plus
