Summary Nursing Pharmacology Test Guide Common Terms and Definitions

Nursing Pharmacology Test Guide Common Terms and Definitions Pharmacokinetics What the body does with the drug Pharmacokinetic phase Absorption, distribution, metabolism, excretion Pharmacodynamics What the drug does to the body Pharmacodynamic Phase Drug concentration and Physiologic effects How do drugs move from the GI tract to the liver? Via portal vein First pass effect Bioavailability Factors affecting absorption Blood flow, pain, stress, ph Exercise, hunger, fasting Food texture, fat content, temperature Route of administration Drug movement from GI tract to liver What is bioavailability? The percentage of administered drug available for activity Factors that affect bioavailability •Absorption •First-pass metabolism •Drug form •Route of administration •Gastric mucosa and motility •Administration with food and other drugs •Changes in liver metabolism Pharmacokinetics: Distribution The movement of the drug from the circulation to body tissues Protein binding The attachment of a drug molecule to a plasma or tissue protein, effectively making the drug inactive but also keeping it within the body Blood proteins include Albumin, lipoproteins, glycoproteins Types of protein binding Highly protein bound or weakly protein bound