Systemic Pharmacology Exam 2 WUCO
2025 Questions and Answers
3 Analgesic Drug Classes. - ....ANSWER ...-NSAIDs,
Opioids,
Migraine Therapies.
Prostaglandins are Important __________ Mediators that are produced locally. -
....ANSWER ...-Important Inflammatory Mediators, Do Not Circulate, stay local.
NSAIDs act by Inhibiting __________. - ....ANSWER ...-Synthesis of
Prostaglandins.
COX is key target of _________. - ....ANSWER ...-NSAIDs.
2 Conventional NSAIDs. - ....ANSWER ...-Acetylsalicylic Acid (Aspirin),
Celecoxib (Celebrex).
Prodrug of Salicylic Acid. - ....ANSWER ...-Aspirin (ASA), inhibits synthesis of the
COX enzyme.
Propionic Acid Derivatives ending. - ....ANSWER ...--profen, (Usually OTC)
Flurbi*profen*,
Ibu*profen*.
…FOR STUDENTS ONLY…©️2025 ALL RIGHTS RESERVED… 1
,Propionic Acid Derivative that has delayed Effects. - ....ANSWER ...-Naproxen,
Long half life.
Acetic Acid Derivatives most commonly used for _________. - ....ANSWER ...-
Arthritic Therapy.
All NSAIDs __________ inhibit COX, unlike ASA. - ....ANSWER ...-NSAIDs
*reversibly* inhibit COX,
ASA irreversibly.
Gold standard NSAID: #1 choice for rheumatoid arthritis. - ....ANSWER ...-ASA,
Aspirin.
ASA 4 Therapeutic Effects. - ....ANSWER ...-Anti-platelet,
Anti-inflammatory,
Anti-pyretic,
Analgesic.
ASA high dose is for __________. - ....ANSWER ...-Anti-Inflammatory.
Another NSAID. - ....ANSWER ...-Acetaminophen (Tylenol).
2 Things Acetaminophen will not do that ASA will. - ....ANSWER ...-
Acetaminophen *No* inflammatory control, *No* Platelet Inhibition.
ASA and Acetaminophen are both __________. - ....ANSWER ...-Anti-pyretic.
Acetaminophen GI effect and Pregnancy Safety. - ....ANSWER ...-No GI Effects,
Safe in Pregnancy.
…FOR STUDENTS ONLY…©️2025 ALL RIGHTS RESERVED… 2
,Aspirin 3 Indication. - ....ANSWER ...-Pain/Fever,
MI,
Arthritis.
Aspirin Mechanism. - ....ANSWER ...-Irreversibly, non-selectively inhibits COX,
reducing PG (prostaglandin) and TXA2 (Thromboxane A2) synthesis.
Aspirin 2 Adverse Effects. - ....ANSWER ...-Bleeding Time Doubles,
Headache.
Aspirin Hypersensitivity. - ....ANSWER ...-Angioedema.
Reye's Syndrome. - ....ANSWER ...-Adverse Reaction in children (15yo) taking
ASA to reduce fever in Viral infection, GI Disturbance, Liver Degeneration,
Encephalopathy.
*35% Mortality*
Aspirin Drug Interaction with NSAIDs. - ....ANSWER ...-Hemorrhage Risk.
Aspirin Drug Interaction with Acetaminophen & Cyclosporine. - ....ANSWER ...-
Nephrotoxicity.
Aspirin Drug Interaction with Steroids. - ....ANSWER ...-GI Toxicity.
Aspirin 5 Contraindications. - ....ANSWER ...-Hemorrhagic Disorders,
Pregnancy esp 3rd trimester,
Corneal denervation (dry eye),
…FOR STUDENTS ONLY…©️2025 ALL RIGHTS RESERVED… 3
, NSAID/ASA induced Asthma,
Chronic GI inflammation/peptic ulcer.
Acetaminophen 2 Indications. - ....ANSWER ...-Pain (mild),
Fever.
Acetaminophen Mechanism. - ....ANSWER ...-Act by inhibiting COX increasing 5-
HT, Regulates body temperature by acting centrally at the hypothalamus; PG synthetase
inhibition.
Acetaminophen 3 Common Adverse Effects - ....ANSWER ...-Nausea,
Rash,
Headache.
Acetaminophen Serious Hepatic Effect. - ....ANSWER ...-Acute Hepatotoxicity
usually with doses *>4g/day* (Leading Drug of choice for Suicide).
Acetaminophen 2 Serious Renal Effects. - ....ANSWER ...-Acute Renal Tubular
Necrosis,
Chronic Analgesic Nephropathy.
Leading Drug of Choice for Suicide. - ....ANSWER ...-Acetaminophen.
Acetaminophen Drug Interaction with Acetaminophen/Antihistaminic Combos. -
....ANSWER ...-Hepatotoxicity.
Acetaminophen Drug Interaction with ASA. - ....ANSWER ...-Nephropathy.
…FOR STUDENTS ONLY…©️2025 ALL RIGHTS RESERVED… 4
2025 Questions and Answers
3 Analgesic Drug Classes. - ....ANSWER ...-NSAIDs,
Opioids,
Migraine Therapies.
Prostaglandins are Important __________ Mediators that are produced locally. -
....ANSWER ...-Important Inflammatory Mediators, Do Not Circulate, stay local.
NSAIDs act by Inhibiting __________. - ....ANSWER ...-Synthesis of
Prostaglandins.
COX is key target of _________. - ....ANSWER ...-NSAIDs.
2 Conventional NSAIDs. - ....ANSWER ...-Acetylsalicylic Acid (Aspirin),
Celecoxib (Celebrex).
Prodrug of Salicylic Acid. - ....ANSWER ...-Aspirin (ASA), inhibits synthesis of the
COX enzyme.
Propionic Acid Derivatives ending. - ....ANSWER ...--profen, (Usually OTC)
Flurbi*profen*,
Ibu*profen*.
…FOR STUDENTS ONLY…©️2025 ALL RIGHTS RESERVED… 1
,Propionic Acid Derivative that has delayed Effects. - ....ANSWER ...-Naproxen,
Long half life.
Acetic Acid Derivatives most commonly used for _________. - ....ANSWER ...-
Arthritic Therapy.
All NSAIDs __________ inhibit COX, unlike ASA. - ....ANSWER ...-NSAIDs
*reversibly* inhibit COX,
ASA irreversibly.
Gold standard NSAID: #1 choice for rheumatoid arthritis. - ....ANSWER ...-ASA,
Aspirin.
ASA 4 Therapeutic Effects. - ....ANSWER ...-Anti-platelet,
Anti-inflammatory,
Anti-pyretic,
Analgesic.
ASA high dose is for __________. - ....ANSWER ...-Anti-Inflammatory.
Another NSAID. - ....ANSWER ...-Acetaminophen (Tylenol).
2 Things Acetaminophen will not do that ASA will. - ....ANSWER ...-
Acetaminophen *No* inflammatory control, *No* Platelet Inhibition.
ASA and Acetaminophen are both __________. - ....ANSWER ...-Anti-pyretic.
Acetaminophen GI effect and Pregnancy Safety. - ....ANSWER ...-No GI Effects,
Safe in Pregnancy.
…FOR STUDENTS ONLY…©️2025 ALL RIGHTS RESERVED… 2
,Aspirin 3 Indication. - ....ANSWER ...-Pain/Fever,
MI,
Arthritis.
Aspirin Mechanism. - ....ANSWER ...-Irreversibly, non-selectively inhibits COX,
reducing PG (prostaglandin) and TXA2 (Thromboxane A2) synthesis.
Aspirin 2 Adverse Effects. - ....ANSWER ...-Bleeding Time Doubles,
Headache.
Aspirin Hypersensitivity. - ....ANSWER ...-Angioedema.
Reye's Syndrome. - ....ANSWER ...-Adverse Reaction in children (15yo) taking
ASA to reduce fever in Viral infection, GI Disturbance, Liver Degeneration,
Encephalopathy.
*35% Mortality*
Aspirin Drug Interaction with NSAIDs. - ....ANSWER ...-Hemorrhage Risk.
Aspirin Drug Interaction with Acetaminophen & Cyclosporine. - ....ANSWER ...-
Nephrotoxicity.
Aspirin Drug Interaction with Steroids. - ....ANSWER ...-GI Toxicity.
Aspirin 5 Contraindications. - ....ANSWER ...-Hemorrhagic Disorders,
Pregnancy esp 3rd trimester,
Corneal denervation (dry eye),
…FOR STUDENTS ONLY…©️2025 ALL RIGHTS RESERVED… 3
, NSAID/ASA induced Asthma,
Chronic GI inflammation/peptic ulcer.
Acetaminophen 2 Indications. - ....ANSWER ...-Pain (mild),
Fever.
Acetaminophen Mechanism. - ....ANSWER ...-Act by inhibiting COX increasing 5-
HT, Regulates body temperature by acting centrally at the hypothalamus; PG synthetase
inhibition.
Acetaminophen 3 Common Adverse Effects - ....ANSWER ...-Nausea,
Rash,
Headache.
Acetaminophen Serious Hepatic Effect. - ....ANSWER ...-Acute Hepatotoxicity
usually with doses *>4g/day* (Leading Drug of choice for Suicide).
Acetaminophen 2 Serious Renal Effects. - ....ANSWER ...-Acute Renal Tubular
Necrosis,
Chronic Analgesic Nephropathy.
Leading Drug of Choice for Suicide. - ....ANSWER ...-Acetaminophen.
Acetaminophen Drug Interaction with Acetaminophen/Antihistaminic Combos. -
....ANSWER ...-Hepatotoxicity.
Acetaminophen Drug Interaction with ASA. - ....ANSWER ...-Nephropathy.
…FOR STUDENTS ONLY…©️2025 ALL RIGHTS RESERVED… 4
