Pharmacodynamics and Pharmacokinetics
competitive antagonist - Drug competes with the agonist for binding to the receptor. If it binds,
there is no response.
CYP34A - Prominent isoenzyme of cytochrome P450
Cytochrome P450 - The general name for a large class of liver enzymes that play a significant
role in drug metabolism and drug interactions
decrease - An enzyme inhibitor will ____ (increase/decrease) production of said enzyme
decreased - hypothermia causes (increased/decreased) metabolism
diffusion - Movement of molecules from an area of higher concentration to an area of lower
concentration.
distribution - how well the drug penetrates the targeted tissue
duration - The period of time which the drug concentration is sufficient to elicit a therapeutic
response
effect - you should always titrate your drugs to ___
excreted - when a drug is ionized in the kidneys it will be ______?
excretion - how the drug is eliminated from the body
, First Order - which order of kinetics is based on the half-life model?
0% - what percentage of CO do vessel-poor tissues receive?
19% - what percentage of CO does muscle and skin receive?
4-5 - how many half lives are required before an infusion reaches the steady state?
4-5 - how many half lives are required to reach a drug concentration around 5%?
6% - what percentage of CO does fat receive?
75% - what percentage of the CO do vessel-rich tissues receive?
Absorption - the bioavailability of a drug is based on
absorption, distribution, metabolism, excretion - 4 phases of pharmacokinetics
acidic - Alkalinizing urine increases excretion of _____ (acidic/basic) drugs.
active, can - A low-protein bound drug is an _____ (active/inactive) drug that _____
(can/cannot) cross the plasma membrane
agonist - medication binds to the same site as an endogenous substance in order to produce the
desired effect
competitive antagonist - Drug competes with the agonist for binding to the receptor. If it binds,
there is no response.
CYP34A - Prominent isoenzyme of cytochrome P450
Cytochrome P450 - The general name for a large class of liver enzymes that play a significant
role in drug metabolism and drug interactions
decrease - An enzyme inhibitor will ____ (increase/decrease) production of said enzyme
decreased - hypothermia causes (increased/decreased) metabolism
diffusion - Movement of molecules from an area of higher concentration to an area of lower
concentration.
distribution - how well the drug penetrates the targeted tissue
duration - The period of time which the drug concentration is sufficient to elicit a therapeutic
response
effect - you should always titrate your drugs to ___
excreted - when a drug is ionized in the kidneys it will be ______?
excretion - how the drug is eliminated from the body
, First Order - which order of kinetics is based on the half-life model?
0% - what percentage of CO do vessel-poor tissues receive?
19% - what percentage of CO does muscle and skin receive?
4-5 - how many half lives are required before an infusion reaches the steady state?
4-5 - how many half lives are required to reach a drug concentration around 5%?
6% - what percentage of CO does fat receive?
75% - what percentage of the CO do vessel-rich tissues receive?
Absorption - the bioavailability of a drug is based on
absorption, distribution, metabolism, excretion - 4 phases of pharmacokinetics
acidic - Alkalinizing urine increases excretion of _____ (acidic/basic) drugs.
active, can - A low-protein bound drug is an _____ (active/inactive) drug that _____
(can/cannot) cross the plasma membrane
agonist - medication binds to the same site as an endogenous substance in order to produce the
desired effect
