1
PBL 1011 Exam 2 Case Drugs Questions
and Correct Answers
Question: What is the class of HCTZ?
Answer: Antihypertensive Thiazide diuretic
Question: what is the mechanism of action of HCTZ
Answer: Thiazide diuretic
inhibits NaCl reabsoprtion in the early DCT
Question: what is the indication for HCTZ (3)
Answer: Hypertension, Treatment of edema due to heart failure, Renal
dysfunction (eg, nephrotic syndrome, acute glomerulosclerosis, chronic
renal failure)
Question: dental implications for HCTZ
Answer: orthostatic hypotension
Question: Are Thiazide diuretics K+ wasting or K+ sparing?
Answer: K+ wasting
Question: class of atenolol?
Answer: Antianginal Agent; Antihypertensive; Beta-Blocker, Beta-1
Selective
Question: mechanism of action of atenolol
Answer: selectively *blocks beta 1 receptors* (will also block beta 2
receptors in high doses); *negative inotropic, chronotropic and
dromotropic properties*; relative vasoconstriction suppresses renin
production thereby lowering blood pressure
Pretest - Stuvia US
,2
Question: indications for atenolol
Answer: treatment of hypertension, (+ angina, prophylaxis and acute
myocardial infarction )
Question: dental implications for atenolol
Answer: Local anesthetic with vasoconstrictor can be safely used in
patients medicated with atenolol.
Question: T/F: an IV α-blocker (e.g., phenoxybenzamine) is given
before β-blockers to prevent unopposed α-adrenergic vasoconstriction
Answer: true
Question: captopril class
Answer: ACE inhibitor
Question: captopril MoA
Answer: * Competitive inhibitor of angiotensin-converting enzyme (ACE).
* results in lower levels of angiotensin II which causes an increase in
plasma renin activity and a redreduction uction in aldosterone secretion.
Question: captopril indication (3)
Answer: hypertension, heart failure, MI
Question: captopril dental implications (2)
Answer: dysguesia, orthostatic hypotension
Question: ACEi drugs cause what metabolic state in the blood?
Answer: hyperkalemia
Question: ACEi drugs should not be used if someone has ......?
Answer: renal hypertension (use clonidine instead)
Pretest - Stuvia US
, 3
Question: Nifedipine class (hint: "-dipine")
Answer: Dihydropyridine Calcium Channel Blocker
Question: nifedipine MoA
Answer: inhibits calcium ion from entering "slow channels"
relaxing smooth muscle
Question: nifedipine indications
Answer: hypertension, angina
Question: nifedipine dental implications
Answer: Xerostomia;
Gingival Hyperplasia (Common to all CCBs)
Question: Nifedipine causes what side effect in Victor Dermody?
Answer: jittery
Question: nitroglycerin class
Answer: Nitrate, angi-angina, vasodilator
Question: nitroglycerin MoA
Answer: NG forms NO, cGMP cascade, smooth muscle relaxation -
VASODILATION on arteries+veins
reduces preload.
Question: nitroglycerin indications
Answer: Acute angina pectoris, hypertension
Question: nitroglycerin dental implications?
Answer: Xerostomia
Question: Dipyridamole (HK) class
Pretest - Stuvia US
PBL 1011 Exam 2 Case Drugs Questions
and Correct Answers
Question: What is the class of HCTZ?
Answer: Antihypertensive Thiazide diuretic
Question: what is the mechanism of action of HCTZ
Answer: Thiazide diuretic
inhibits NaCl reabsoprtion in the early DCT
Question: what is the indication for HCTZ (3)
Answer: Hypertension, Treatment of edema due to heart failure, Renal
dysfunction (eg, nephrotic syndrome, acute glomerulosclerosis, chronic
renal failure)
Question: dental implications for HCTZ
Answer: orthostatic hypotension
Question: Are Thiazide diuretics K+ wasting or K+ sparing?
Answer: K+ wasting
Question: class of atenolol?
Answer: Antianginal Agent; Antihypertensive; Beta-Blocker, Beta-1
Selective
Question: mechanism of action of atenolol
Answer: selectively *blocks beta 1 receptors* (will also block beta 2
receptors in high doses); *negative inotropic, chronotropic and
dromotropic properties*; relative vasoconstriction suppresses renin
production thereby lowering blood pressure
Pretest - Stuvia US
,2
Question: indications for atenolol
Answer: treatment of hypertension, (+ angina, prophylaxis and acute
myocardial infarction )
Question: dental implications for atenolol
Answer: Local anesthetic with vasoconstrictor can be safely used in
patients medicated with atenolol.
Question: T/F: an IV α-blocker (e.g., phenoxybenzamine) is given
before β-blockers to prevent unopposed α-adrenergic vasoconstriction
Answer: true
Question: captopril class
Answer: ACE inhibitor
Question: captopril MoA
Answer: * Competitive inhibitor of angiotensin-converting enzyme (ACE).
* results in lower levels of angiotensin II which causes an increase in
plasma renin activity and a redreduction uction in aldosterone secretion.
Question: captopril indication (3)
Answer: hypertension, heart failure, MI
Question: captopril dental implications (2)
Answer: dysguesia, orthostatic hypotension
Question: ACEi drugs cause what metabolic state in the blood?
Answer: hyperkalemia
Question: ACEi drugs should not be used if someone has ......?
Answer: renal hypertension (use clonidine instead)
Pretest - Stuvia US
, 3
Question: Nifedipine class (hint: "-dipine")
Answer: Dihydropyridine Calcium Channel Blocker
Question: nifedipine MoA
Answer: inhibits calcium ion from entering "slow channels"
relaxing smooth muscle
Question: nifedipine indications
Answer: hypertension, angina
Question: nifedipine dental implications
Answer: Xerostomia;
Gingival Hyperplasia (Common to all CCBs)
Question: Nifedipine causes what side effect in Victor Dermody?
Answer: jittery
Question: nitroglycerin class
Answer: Nitrate, angi-angina, vasodilator
Question: nitroglycerin MoA
Answer: NG forms NO, cGMP cascade, smooth muscle relaxation -
VASODILATION on arteries+veins
reduces preload.
Question: nitroglycerin indications
Answer: Acute angina pectoris, hypertension
Question: nitroglycerin dental implications?
Answer: Xerostomia
Question: Dipyridamole (HK) class
Pretest - Stuvia US
