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What3 0 is3 0 ACHE?3 0 -
✔✔✔3 0 Correct3 0 Answer3 0 >3 0 Acetylcholine3 0 esterase3 0 is3 0 an3 0 enz
yme3 0 th30at3 0 metabolizes3 0 ACh.
What3 0 are3 0 the3 0 active3 0 metabolites3 0 of3 0 benzodiazepines?3 0 -
✔✔✔3 0 Correct3 0 Answer3 0 >3 0 Diazepam3 0 (with3 0 a3 0 half-
life3 0 exceeding3 0 1003 0 hours)3 0 and3 0 midazolam3 0 (rapidly3 0 metaboli
zed3 0 to30an3 0 α-hydroxylated3 0 compound3 0 with3 0 biologic3 0 activity).
What3 0 effect3 0 do3 0 high3 0 doses3 0 of3 0 benzodiazepines3 0 have3 0 on3 0 C
MR023 0 &3 0 CBF?3 0 -
✔✔✔3 0 Correct3 0 Answer3 0 >3 0 They3 0 reduce3 0 CMR023 0 &3 0 CBF.
,What55are55the55adverse55effects55of55midazolam?55-
55 ✔✔✔55Correct55Answer55>55Prolonged55sedation,55impaired55cognitio
n55and55psychomotor55performance,55unwanted55amnesia,55potential553
0 for55delirium,55increased55risk55of55accidents55and55falls,55dependence55
30 and55withdrawal55effects
What55effect55do55benzodiazepines55have55on55the55threshold55to55local
55 anesthetic-induced55seizures?55-
55 ✔✔✔55Correct55Answer55>55They55increase55the55threshold55to55local55
anesthetic-induced55seizures.
Which55benzodiazepines55have55no55active55metabolites?55-
55 ✔✔✔55Correct55Answer55>55Oxazepam,55lorazepam,55and55temazepam.
What55factors55can55alter55the55metabolism55of55benzodiazepines?55-
55✔✔✔
Correct55Answer55>55Disease55and55age.
,What55is55the55duration55of55action55of55benzodiazepines55primarily55deter
30 mined55by?55-55✔✔✔55Correct55Answer55>55The55α55phase55(distribution-
30 redistribution55from55CNS)55dynamics55rather55than55the55rate55of55elim
i30nation.
What55are55the55pharmacodynamic55effects55of55benzodiazepines55on55th
e CNS?55-
30 55
55 ✔✔✔55Correct55Answer55>55CNS55depressant55effects55including55anxi
olysis,55sedation,55sleep,55anticonvulsant,55amnesia,55muscle55relaxatio30n,55
and55inhibition55of55alcohol55withdrawal55symptoms.
What55is55the55dose-
30 related55effect55of55benzodiazepines55on55anterograde55amnesia?55
-
55 ✔✔✔55Correct55Answer55>55They55cause55anterograde55amnesia55at55hi
gh55doses.
, What55are55the55potential55drawbacks55of55benzodiazepine55use?55-55✔✔✔