HESI Pathophysiology Question With
Correct Answers 2025
Which of the following best describes the pathophysiology of asthma?
a) Excessive mucus production in the airways leading to obstruction
b) Chronic inflammation and bronchoconstriction of the airways
c) Destruction of alveoli and decreased lung elasticity
d) Thickening and scarring of lung tissue leading to reduced compliance<correct
answers>b) chronic inflammation and bronchoconstriction of the airways
A patient with diabetes mellitus is experiencing polyuria, polydipsia, and polyphagia.
Which of the following pathophysiological mechanisms is primarily responsible for these
symptoms?
a) Hyperglycemia-induced osmotic diuresis
b) Decreased insulin production by the pancreas
c) Insulin resistance at the cellular level
d) Glycosylation of proteins leading to tissue damage<correct answers>a)
hyperglycemia-induced osmotic diuresis
In a patient with congestive heart failure, which of the following pathophysiological
changes is most likely to occur initially as a compensatory mechanism?
a) Activation of the renin-angiotensin-aldosterone system (RAAS)
b) Sympathetic nervous system stimulation
c) Ventricular hypertrophy
d) Pulmonary vasoconstriction<correct answers>b) sympathetic nervous system
stimulation
What is the primary pathophysiological mechanism underlying rheumatoid arthritis?
a) Autoimmune destruction of joint cartilage and synovial membrane
b) Degeneration of articular cartilage due to mechanical stress
c) Accumulation of uric acid crystals in the joints
d) Excessive production of synovial fluid leading to joint effusion<correct answers>a)
autoimmune destruction of joint cartilage and synovial membrane
Which of the following pathophysiological changes is characteristic of chronic
obstructive pulmonary disease (COPD)?
a) Destruction of alveoli and loss of lung elasticity
b) Inflammation and scarring of the pleura
c) Increased production of surfactant in the lungs
d) Constriction of bronchioles due to smooth muscle hypertrophy<correct answers>a)
destruction of alveoli and loss of lung elasticity
What is the primary pathophysiological mechanism underlying ischemic stroke?
a) Blockage of cerebral blood vessels by a thrombus or embolus
,b) Rupture of cerebral blood vessels leading to hemorrhage
c) Impaired cerebral perfusion due to systemic hypotension
d) Compression of cerebral tissue by a tumor or hematoma<correct answers>a)
blockage of cerebral blood vessels by a thrombus or embolus
Which of the following pathophysiological mechanisms is responsible for the
development of chronic kidney disease (CKD)?
a) Glomerular hyperfiltration and hypertrophy
b) Immune-mediated destruction of renal tubules
c) Obstruction of urinary flow due to kidney stones
d) Progressive loss of nephrons and renal function over time<correct answers>d)
progressive loss of nephrons and renal function over time
In a patient with type 2 diabetes mellitus, which of the following pathophysiological
changes is primarily responsible for insulin resistance?
a) Decreased secretion of insulin by pancreatic beta cells
b) Impaired glucose uptake by peripheral tissues
c) Hyperglycemia-induced inhibition of insulin receptor signaling
d) Dysregulation of hepatic glucose production<correct answers>b) impaired glucose
uptake by peripheral tissues
Which of the following pathophysiological mechanisms is associated with the
development of peptic ulcer disease?
a) Excessive production of gastric acid by parietal cells
b) Impaired mucosal blood flow leading to ischemia
c) Chronic inflammation and infection with Helicobacter pylori
d) Dysfunction of the lower esophageal sphincter allowing reflux of gastric
contents<correct answers>c) chronic inflammation and infection with H. pylori
What is the primary pathophysiological mechanism underlying Alzheimer's disease?
a) Accumulation of amyloid plaques and neurofibrillary tangles in the brain
b) Degeneration of motor neurons in the spinal cord
c) Impaired transmission of acetylcholine at the neuromuscular junction
d) Blockage of cerebral blood vessels by thrombi or emboli<correct answers>a)
accumulation of amyloid plaques and neurofibrillary tangles in the brain
What is the primary cause of cystic fibrosis?
a) Autoimmune destruction of pancreatic beta cells
b) Excessive production of mucus by bronchial glands
c) Mutations in the CFTR gene leading to defective chloride ion transport
d) Chronic exposure to tobacco smoke and environmental pollutants<correct
answers>c) mutations in the CFTR gene leading to defective chloride ion transport
What is the primary pathophysiological mechanism underlying Parkinson's disease?
a) Degeneration of dopaminergic neurons in the substantia nigra of the brain
b) Impaired transmission of serotonin in the spinal cord
,c) Accumulation of tau protein aggregates in the cerebral cortex
d) Blockage of cerebral blood vessels by atherosclerotic plaques<correct answers>a)
degeneration of dopaminergic neurons in the substantia nigra of the brain
Which of the following pathophysiological mechanisms is associated with the
development of osteoporosis?
a) Excessive production of parathyroid hormone leading to bone resorption
b) Decreased synthesis of collagen by osteoblasts
c) Impaired blood supply to bone tissues causing necrosis
d) Chronic inflammation of the synovial membrane in the joints<correct answers>a)
excessive production of parathyroid hormone leading to bone reabsorption
What is the primary pathophysiological mechanism underlying myocardial infarction?
a) Blockage of coronary arteries by atherosclerotic plaques
b) Impaired electrical conduction in the myocardium
c) Chronic hypertension leading to left ventricular hypertrophy
d) Dysfunction of heart valves resulting in regurgitation of blood<correct answers>a)
blockage of coronary arteries by atherosclerotic plaques
What is the primary pathophysiological mechanism underlying Type 1 diabetes
mellitus?
a) Insulin resistance in peripheral tissues
b) Autoimmune destruction of pancreatic beta cells
c) Impaired insulin secretion by pancreatic alpha cells
d) Dysfunction of insulin receptors on target cells<correct answers>b) autoimmune
destruction of pancreatic beta cells
Which of the following pathophysiological changes is characteristic of multiple sclerosis
(MS)?
a) Degeneration of motor neurons in the spinal cord
b) Loss of myelin sheath in the central nervous system
c) Impaired production of dopamine in the basal ganglia
d) Excessive production of cerebrospinal fluid in the ventricles<correct answers>b) loss
of myelin sheath in the central nervous system
What is the primary cause of chronic liver disease?
a) Autoimmune attack on hepatocytes
b) Chronic alcohol abuse
c) Viral infection of liver cells
d) Impaired blood supply to the liver<correct answers>c) viral infection of liver cells
Which of the following pathophysiological mechanisms is associated with the
development of gastroesophageal reflux disease (GERD)?
a) Chronic inflammation of the gastric mucosa
b) Excessive production of gastric acid by parietal cells
c) Dysfunction of the lower esophageal sphincter
, d) Impaired motility of the esophagus<correct answers>c) dysfunction of the lower
esophageal sphincter
What is the primary pathophysiological mechanism underlying systemic lupus
erythematosus (SLE)?
a) Chronic inflammation and immune complex deposition in various tissues
b) Degeneration of neurons in the central nervous system
c) Excessive production of thyroid hormone by the thyroid gland
d) Impaired blood clotting due to deficiency of clotting factors<correct answers>a)
chronic inflammation and immune complex deposition in various tissues
Which of the following pathophysiological mechanisms is responsible for the
development of rheumatic heart disease?
a) Chronic inflammation and scarring of heart valves
b) Excessive production of thyroid hormone
c) Autoimmune destruction of cardiac muscle cells
d) Impaired electrical conduction in the heart<correct answers>a) chronic inflammation
and scarring of heart valves
What is the primary pathophysiological mechanism underlying cystitis?
a) Obstruction of the urinary tract by kidney stones
b) Bacterial infection of the bladder wall
c) Chronic inflammation of the urethra
d) Impaired filtration by the glomeruli in the kidney<correct answers>b) bacterial
infection of the bladder wall
Which of the following pathophysiological changes is characteristic of anemia?
a) Excessive production of red blood cells by the bone marrow
b) Decreased hemoglobin concentration in the blood
c) Impaired coagulation of blood
d) Chronic inflammation of blood vessels<correct answers>b) decreased hgb
concentration in the blood
What is the primary cause of osteoarthritis?
a) Autoimmune attack on joint tissues
b) Excessive production of uric acid crystals in the joints
c) Degeneration of articular cartilage due to mechanical stress
d) Impaired blood supply to the joints<correct answers>c) degeneration of articular
cartilage due to mechanical stress
Which of the following pathophysiological mechanisms is primarily responsible for the
development of atherosclerosis?
a) Chronic inflammation of the arterial walls
b) Excessive production of LDL cholesterol by the liver
c) Impaired contraction of smooth muscle cells in the arteries
Correct Answers 2025
Which of the following best describes the pathophysiology of asthma?
a) Excessive mucus production in the airways leading to obstruction
b) Chronic inflammation and bronchoconstriction of the airways
c) Destruction of alveoli and decreased lung elasticity
d) Thickening and scarring of lung tissue leading to reduced compliance<correct
answers>b) chronic inflammation and bronchoconstriction of the airways
A patient with diabetes mellitus is experiencing polyuria, polydipsia, and polyphagia.
Which of the following pathophysiological mechanisms is primarily responsible for these
symptoms?
a) Hyperglycemia-induced osmotic diuresis
b) Decreased insulin production by the pancreas
c) Insulin resistance at the cellular level
d) Glycosylation of proteins leading to tissue damage<correct answers>a)
hyperglycemia-induced osmotic diuresis
In a patient with congestive heart failure, which of the following pathophysiological
changes is most likely to occur initially as a compensatory mechanism?
a) Activation of the renin-angiotensin-aldosterone system (RAAS)
b) Sympathetic nervous system stimulation
c) Ventricular hypertrophy
d) Pulmonary vasoconstriction<correct answers>b) sympathetic nervous system
stimulation
What is the primary pathophysiological mechanism underlying rheumatoid arthritis?
a) Autoimmune destruction of joint cartilage and synovial membrane
b) Degeneration of articular cartilage due to mechanical stress
c) Accumulation of uric acid crystals in the joints
d) Excessive production of synovial fluid leading to joint effusion<correct answers>a)
autoimmune destruction of joint cartilage and synovial membrane
Which of the following pathophysiological changes is characteristic of chronic
obstructive pulmonary disease (COPD)?
a) Destruction of alveoli and loss of lung elasticity
b) Inflammation and scarring of the pleura
c) Increased production of surfactant in the lungs
d) Constriction of bronchioles due to smooth muscle hypertrophy<correct answers>a)
destruction of alveoli and loss of lung elasticity
What is the primary pathophysiological mechanism underlying ischemic stroke?
a) Blockage of cerebral blood vessels by a thrombus or embolus
,b) Rupture of cerebral blood vessels leading to hemorrhage
c) Impaired cerebral perfusion due to systemic hypotension
d) Compression of cerebral tissue by a tumor or hematoma<correct answers>a)
blockage of cerebral blood vessels by a thrombus or embolus
Which of the following pathophysiological mechanisms is responsible for the
development of chronic kidney disease (CKD)?
a) Glomerular hyperfiltration and hypertrophy
b) Immune-mediated destruction of renal tubules
c) Obstruction of urinary flow due to kidney stones
d) Progressive loss of nephrons and renal function over time<correct answers>d)
progressive loss of nephrons and renal function over time
In a patient with type 2 diabetes mellitus, which of the following pathophysiological
changes is primarily responsible for insulin resistance?
a) Decreased secretion of insulin by pancreatic beta cells
b) Impaired glucose uptake by peripheral tissues
c) Hyperglycemia-induced inhibition of insulin receptor signaling
d) Dysregulation of hepatic glucose production<correct answers>b) impaired glucose
uptake by peripheral tissues
Which of the following pathophysiological mechanisms is associated with the
development of peptic ulcer disease?
a) Excessive production of gastric acid by parietal cells
b) Impaired mucosal blood flow leading to ischemia
c) Chronic inflammation and infection with Helicobacter pylori
d) Dysfunction of the lower esophageal sphincter allowing reflux of gastric
contents<correct answers>c) chronic inflammation and infection with H. pylori
What is the primary pathophysiological mechanism underlying Alzheimer's disease?
a) Accumulation of amyloid plaques and neurofibrillary tangles in the brain
b) Degeneration of motor neurons in the spinal cord
c) Impaired transmission of acetylcholine at the neuromuscular junction
d) Blockage of cerebral blood vessels by thrombi or emboli<correct answers>a)
accumulation of amyloid plaques and neurofibrillary tangles in the brain
What is the primary cause of cystic fibrosis?
a) Autoimmune destruction of pancreatic beta cells
b) Excessive production of mucus by bronchial glands
c) Mutations in the CFTR gene leading to defective chloride ion transport
d) Chronic exposure to tobacco smoke and environmental pollutants<correct
answers>c) mutations in the CFTR gene leading to defective chloride ion transport
What is the primary pathophysiological mechanism underlying Parkinson's disease?
a) Degeneration of dopaminergic neurons in the substantia nigra of the brain
b) Impaired transmission of serotonin in the spinal cord
,c) Accumulation of tau protein aggregates in the cerebral cortex
d) Blockage of cerebral blood vessels by atherosclerotic plaques<correct answers>a)
degeneration of dopaminergic neurons in the substantia nigra of the brain
Which of the following pathophysiological mechanisms is associated with the
development of osteoporosis?
a) Excessive production of parathyroid hormone leading to bone resorption
b) Decreased synthesis of collagen by osteoblasts
c) Impaired blood supply to bone tissues causing necrosis
d) Chronic inflammation of the synovial membrane in the joints<correct answers>a)
excessive production of parathyroid hormone leading to bone reabsorption
What is the primary pathophysiological mechanism underlying myocardial infarction?
a) Blockage of coronary arteries by atherosclerotic plaques
b) Impaired electrical conduction in the myocardium
c) Chronic hypertension leading to left ventricular hypertrophy
d) Dysfunction of heart valves resulting in regurgitation of blood<correct answers>a)
blockage of coronary arteries by atherosclerotic plaques
What is the primary pathophysiological mechanism underlying Type 1 diabetes
mellitus?
a) Insulin resistance in peripheral tissues
b) Autoimmune destruction of pancreatic beta cells
c) Impaired insulin secretion by pancreatic alpha cells
d) Dysfunction of insulin receptors on target cells<correct answers>b) autoimmune
destruction of pancreatic beta cells
Which of the following pathophysiological changes is characteristic of multiple sclerosis
(MS)?
a) Degeneration of motor neurons in the spinal cord
b) Loss of myelin sheath in the central nervous system
c) Impaired production of dopamine in the basal ganglia
d) Excessive production of cerebrospinal fluid in the ventricles<correct answers>b) loss
of myelin sheath in the central nervous system
What is the primary cause of chronic liver disease?
a) Autoimmune attack on hepatocytes
b) Chronic alcohol abuse
c) Viral infection of liver cells
d) Impaired blood supply to the liver<correct answers>c) viral infection of liver cells
Which of the following pathophysiological mechanisms is associated with the
development of gastroesophageal reflux disease (GERD)?
a) Chronic inflammation of the gastric mucosa
b) Excessive production of gastric acid by parietal cells
c) Dysfunction of the lower esophageal sphincter
, d) Impaired motility of the esophagus<correct answers>c) dysfunction of the lower
esophageal sphincter
What is the primary pathophysiological mechanism underlying systemic lupus
erythematosus (SLE)?
a) Chronic inflammation and immune complex deposition in various tissues
b) Degeneration of neurons in the central nervous system
c) Excessive production of thyroid hormone by the thyroid gland
d) Impaired blood clotting due to deficiency of clotting factors<correct answers>a)
chronic inflammation and immune complex deposition in various tissues
Which of the following pathophysiological mechanisms is responsible for the
development of rheumatic heart disease?
a) Chronic inflammation and scarring of heart valves
b) Excessive production of thyroid hormone
c) Autoimmune destruction of cardiac muscle cells
d) Impaired electrical conduction in the heart<correct answers>a) chronic inflammation
and scarring of heart valves
What is the primary pathophysiological mechanism underlying cystitis?
a) Obstruction of the urinary tract by kidney stones
b) Bacterial infection of the bladder wall
c) Chronic inflammation of the urethra
d) Impaired filtration by the glomeruli in the kidney<correct answers>b) bacterial
infection of the bladder wall
Which of the following pathophysiological changes is characteristic of anemia?
a) Excessive production of red blood cells by the bone marrow
b) Decreased hemoglobin concentration in the blood
c) Impaired coagulation of blood
d) Chronic inflammation of blood vessels<correct answers>b) decreased hgb
concentration in the blood
What is the primary cause of osteoarthritis?
a) Autoimmune attack on joint tissues
b) Excessive production of uric acid crystals in the joints
c) Degeneration of articular cartilage due to mechanical stress
d) Impaired blood supply to the joints<correct answers>c) degeneration of articular
cartilage due to mechanical stress
Which of the following pathophysiological mechanisms is primarily responsible for the
development of atherosclerosis?
a) Chronic inflammation of the arterial walls
b) Excessive production of LDL cholesterol by the liver
c) Impaired contraction of smooth muscle cells in the arteries
