NR507 WEEK 1 EXAM WITH
CORRECT ANSWERS 2025
GRADED A+
Neutrophils correct answers >> first responders
Type 1 hypersensitivity REACTION correct answers >>
-IgE mediated
-Ex: Asthma, allergic rhinitis, atopic dermatitis,
anaphylactic shock, urticaria, angioedema
LOCAL OR SYSTEMIC
Type 2 (Cytotoxic) hypersensitivity reactions are
mediated by correct answers >> IgG or IgM.
Sensitization correct answers >> Developing a
sensitivity to a substance that initially caused no allergic
reaction.
,After the allergen is cleared, the remaining IgE molecules
will be bound by mast cells, basophils, and eosinophils
that contain receptors for the IgE molecules.
Immediate degranulation correct answers >> causes
the release of inflammatory mediators such as histamine,
leukotrienes, and prostaglandins that results in
vasodilation, bronchial smooth muscle contraction, and
mucus production
Systemic reactions correct answers >> involve
basophil degranulation; they occur throughout the body,
can lead to anaphylactic shock, and can be life-
threatening EX. ALLERGIC ASTHMA
Type II hypersensitivity reaction correct answers >>
-Cytotoxic
-Antibody attacks the antigen leading to lysis
(complement mediated)
-IgG & IgM are the principal antibodies involved
-Examples: hemolytic anemia, thrombocytopenia
Hapten correct answers >> small molecule that has
to bind to a larger molecule to form an antigen
CAN CAUSE AN IMMUNE RESPONSE WHEN IT ATTACHES
TO A PROTEIN.
, MACROPHAGES ROLE IN TYPE 11 HYPERSENSITIVITY
correct answers >> primary effector cells of Type II
responses
Examples of Type II reactions correct answers >>
drug allergies, hemolytic anemia, blood transfusion
mismatch with resulting transfusion reaction and Rh
hemolytic disease.
Type II responses (antibody binds to antigen where? What
happens?) correct answers >> The cell surface and
cause:
The cell to be destroyed by the antibody
Cell destruction through phagocytosis by macrophages
Damage to the cell by neutrophils triggering phagocytosis
Natural killer cells to release toxic substances that
destroy the target cell
Malfunction of the cell without destruction
Type III hypersensitivity reaction binds where? correct
answers >> antibody binds to the antigen in the blood
or body fluids and then circulates to the tissue.
CORRECT ANSWERS 2025
GRADED A+
Neutrophils correct answers >> first responders
Type 1 hypersensitivity REACTION correct answers >>
-IgE mediated
-Ex: Asthma, allergic rhinitis, atopic dermatitis,
anaphylactic shock, urticaria, angioedema
LOCAL OR SYSTEMIC
Type 2 (Cytotoxic) hypersensitivity reactions are
mediated by correct answers >> IgG or IgM.
Sensitization correct answers >> Developing a
sensitivity to a substance that initially caused no allergic
reaction.
,After the allergen is cleared, the remaining IgE molecules
will be bound by mast cells, basophils, and eosinophils
that contain receptors for the IgE molecules.
Immediate degranulation correct answers >> causes
the release of inflammatory mediators such as histamine,
leukotrienes, and prostaglandins that results in
vasodilation, bronchial smooth muscle contraction, and
mucus production
Systemic reactions correct answers >> involve
basophil degranulation; they occur throughout the body,
can lead to anaphylactic shock, and can be life-
threatening EX. ALLERGIC ASTHMA
Type II hypersensitivity reaction correct answers >>
-Cytotoxic
-Antibody attacks the antigen leading to lysis
(complement mediated)
-IgG & IgM are the principal antibodies involved
-Examples: hemolytic anemia, thrombocytopenia
Hapten correct answers >> small molecule that has
to bind to a larger molecule to form an antigen
CAN CAUSE AN IMMUNE RESPONSE WHEN IT ATTACHES
TO A PROTEIN.
, MACROPHAGES ROLE IN TYPE 11 HYPERSENSITIVITY
correct answers >> primary effector cells of Type II
responses
Examples of Type II reactions correct answers >>
drug allergies, hemolytic anemia, blood transfusion
mismatch with resulting transfusion reaction and Rh
hemolytic disease.
Type II responses (antibody binds to antigen where? What
happens?) correct answers >> The cell surface and
cause:
The cell to be destroyed by the antibody
Cell destruction through phagocytosis by macrophages
Damage to the cell by neutrophils triggering phagocytosis
Natural killer cells to release toxic substances that
destroy the target cell
Malfunction of the cell without destruction
Type III hypersensitivity reaction binds where? correct
answers >> antibody binds to the antigen in the blood
or body fluids and then circulates to the tissue.
