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HESI A2 Vocabulary & General Knowledge Practice Questions – 80 Questions with Answers

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Get ready for the HESI A2 Vocabulary and General Knowledge section with this focused set of 80 exam-style practice questions. Topics include commonly tested vocabulary, medical terminology, word usage, and general language concepts. Each question includes the correct answer and a clear explanation to build your confidence and language proficiency—perfect for nursing school applicants aiming to boost their HESI score.

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HESI A2 Vocabulary and General Knowledge Practice
Questions
80 Multiple-Choice Questions for Exam Preparation



1. Vocabulary and General Knowledge
1. What is the meaning of the term ”abate”?
A. To increase
B. To reduce or lessen
C. To maintain
D. To eliminate completely
Correct Answer: B. To reduce or lessen
2. Which term refers to a substance that causes an allergic reaction?
A. Antigen
B. Antibody
C. Antiseptic
D. Antibiotic
Correct Answer: A. Antigen
3. What does the prefix ”hypo-” mean in medical terminology?
A. Above
B. Below
C. Equal
D. Across
Correct Answer: B. Below
4. What is the meaning of ”prognosis”?
A. The cause of a disease
B. The predicted outcome of a disease
C. The treatment plan
D. The diagnosis process
Correct Answer: B. The predicted outcome of a disease
5. Which term describes a sudden and severe health event, such as a heart attack?
A. Chronic
B. Acute
C. Benign
D. Malignant
Correct Answer: B. Acute
6. What does the term ”edema” refer to?
A. Swelling due to fluid accumulation
B. High blood pressure
C. Low blood sugar
D. Bone fracture


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, Correct Answer: A. Swelling due to fluid accumulation
7. What is the meaning of ”benign”?
A. Harmful
B. Non-cancerous
C. Infectious
D. Chronic
Correct Answer: B. Non-cancerous
8. Which term refers to the surgical removal of a body part?
A. Amputation
B. Incision
C. Suture
D. Biopsy
Correct Answer: A. Amputation
9. What does ”distal” mean in anatomical terms?
A. Closer to the point of attachment
B. Farther from the point of attachment
C. Toward the midline
D. Above the structure
Correct Answer: B. Farther from the point of attachment
10. What is the meaning of ”pathogen”?
A. A disease-causing organism
B. A type of vaccine
C. A blood cell
D. A surgical tool
Correct Answer: A. A disease-causing organism
11. What does the term ”aseptic” mean?
A. Free from contamination
B. Painful
C. Chronic
D. Infectious
Correct Answer: A. Free from contamination
12. Which term describes a condition that persists over a long period?
A. Acute
B. Chronic
C. Transient
D. Episodic
Correct Answer: B. Chronic
13. What is the meaning of ”etiology”?
A. The study of disease causes
B. The treatment of symptoms
C. The prevention of disease
D. The outcome of a condition
Correct Answer: A. The study of disease causes
14. What does the prefix ”tachy-” indicate?


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