2025|130 QUESTIONS WITH ACCURATE SOLUTIONS
phosphorylation
increased gene repression; covalent modification of cytosine bases of CpG
interaction of chromatin with RNA polymerase; aberrant hypermethylation of
, interphase DNA packing in the cell; DNA, RNA, proteins
done by serine residues
progesterone and 17-hydroxyprogesterone
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2 of 130
Term
V600K
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valine to lysine mutation in
mechanistic target of rapamycin
melanoma
inhibitor of ALK and MET tyrosine valine to glutamic acid mutation in
kinases melanoma
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3 of 130
Definition
,threonine/tyrosine kinase; activates MAPKs; common genetic
alteration in melanoma
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MEK lung cancer
c-KIT melanoma
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4 of 130
Term
chromosome
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interferes with GnRH receptor metaphase DNA packing in
signaling; degarelix and medical the cell; highest level of DNA
castration; receptor packing
executioner proteins (activate
progesterone and 17-
apoptosis); positive for killing
hydroxyprogesterone
cancer cells
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, 5 of 130
Definition
more risk factors is associated with worse survival; metastatic renal
cell carcinoma
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gas exchange sex steroids
Heng criteria prostate gland
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6 of 130
Definition
enzalutamide, tamoxifen; blocks binding of steroid hormone to the
ligand-binding domain of the receptor, thereby preventing nuclear
translocation, recruitment of co-factors, binding to DNA, and
driving of transcription
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inhibition of peripheral conversion triple negative/basal-like breast
of steroids cancer