Pharmacology
Final
NUR[117] Pearce
,Pharmacokinetics/ Pharmacodynamics
Pharmacokinetics Pharmacodynamics
Pharmacokinetics is what the Pharmacodynamics explains
drug does to the body, it what a drug does to the body.
includes the processes such as It focuses on the drug’s
absorption, distribution, mechanism of the action and its
metabolism, and excretion. physiological effects on
receptors, tissues, and organ
Pharmacokinetics is the systems.
journey of the drug through
the body. Pharmacodynamics covers the
drug’s effects and the
interactions within the body.
2
,A
bsorption D istribution M
etabolism E
xcretion
Absorption Metabolism
01 Aka BIOAVAILABILITY, it is the 03 Aka BIOTRANSFORMATION, involving
movement of a drug from its biochemical alteration into an inactive
site of administration into the metabolite, a soluble compound, a potent
bloodstream for distribution to active metabolite, or less active
the tissues. metabolite.
Distribution Excretion
02 Refers to the transport of a 04 The process by which drugs and
drug by the blood stream to their metabolites are eliminated
its site of action. from the body. The primary organ
for excretion is the KIDNEYS.
3
, HALF-LIFE
The time required for the concentration or amount of
a drug in the body to be reduced by one-half
through metabolic process.
Definitions:
Onset → action of time required for the drug to elicit a
therapeutic response.
Peak → is the time required for a drug to reach its maximum
therapeutic response
Trough → Is the lowest blood level of a drug
Duration → Is the action of a drug is the length that the drug
concentration is sufficient to elicit a therapeutic response. 4
Final
NUR[117] Pearce
,Pharmacokinetics/ Pharmacodynamics
Pharmacokinetics Pharmacodynamics
Pharmacokinetics is what the Pharmacodynamics explains
drug does to the body, it what a drug does to the body.
includes the processes such as It focuses on the drug’s
absorption, distribution, mechanism of the action and its
metabolism, and excretion. physiological effects on
receptors, tissues, and organ
Pharmacokinetics is the systems.
journey of the drug through
the body. Pharmacodynamics covers the
drug’s effects and the
interactions within the body.
2
,A
bsorption D istribution M
etabolism E
xcretion
Absorption Metabolism
01 Aka BIOAVAILABILITY, it is the 03 Aka BIOTRANSFORMATION, involving
movement of a drug from its biochemical alteration into an inactive
site of administration into the metabolite, a soluble compound, a potent
bloodstream for distribution to active metabolite, or less active
the tissues. metabolite.
Distribution Excretion
02 Refers to the transport of a 04 The process by which drugs and
drug by the blood stream to their metabolites are eliminated
its site of action. from the body. The primary organ
for excretion is the KIDNEYS.
3
, HALF-LIFE
The time required for the concentration or amount of
a drug in the body to be reduced by one-half
through metabolic process.
Definitions:
Onset → action of time required for the drug to elicit a
therapeutic response.
Peak → is the time required for a drug to reach its maximum
therapeutic response
Trough → Is the lowest blood level of a drug
Duration → Is the action of a drug is the length that the drug
concentration is sufficient to elicit a therapeutic response. 4
