MODULE 1 BIO351: PROBLEM SET 1
EXAM BIO351, 2025/2026 WITH
CORRECT/ACCURATE ANSWERS
What is the predicted function of the Duffy gene?
- Cell Adhesion Molecule
- RNA Polymerase II
- Microfilament
- Transcription Factor
- Chemokine Receptor - CORRECT ANSWERS- - Chemokine
Receptor
from the description: "The Duffy Protein is a chemokine receptor
expressed on many different types of cells. It is also a receptor for
'Plasmodium vivax', one of the parasites that invade red blood
cells (RBCs) and cause malaria."
How does the GA(T>C)A mutation in the Duffy promoter provide
malaria resistance?
- Plasmodium vivax can't bind to Endothelial cells
- Plasmodium vivax can't bind to Blood Cells
, - Duffy has not effect on malarial resistance
- Reduced Duffy expression is toxic to malarial parasite
Plasmodium vivax - CORRECT ANSWERS- - Plasmodium vivax
can't bind to Blood Cells
For the mutated Duffy cell, there are no visible receptors on the
cell's surface! Additionally, we are talking about RED BLOOD
CELLS ... not endothelial cells (there is no indication that this
impacts endothelial cells).
How does the GA(T>C)A mutation in the Duffy promoter impact
Duffy transcription?
- The transcription factor that binds the GATA enhance doesn't
bind GACA.
- GACA enhancer does not release the transcription factor
- The mutation from T > C blocks Duffy mRNA splicing.
- The mutation from T > C inhibits Duffy mRNA binding to
ribosomes - CORRECT ANSWERS- - The transcription factor that
binds the GATA enhance doesn't bind GACA.
There is a notable change in the gene from GATA to GACA. This
mutation in the gene sequence (at the ENHANCER region) likely
will prevent the transcription factors from interacting with the
gene. Thus, the expression for Duffy will NOT be driven forward.
EXAM BIO351, 2025/2026 WITH
CORRECT/ACCURATE ANSWERS
What is the predicted function of the Duffy gene?
- Cell Adhesion Molecule
- RNA Polymerase II
- Microfilament
- Transcription Factor
- Chemokine Receptor - CORRECT ANSWERS- - Chemokine
Receptor
from the description: "The Duffy Protein is a chemokine receptor
expressed on many different types of cells. It is also a receptor for
'Plasmodium vivax', one of the parasites that invade red blood
cells (RBCs) and cause malaria."
How does the GA(T>C)A mutation in the Duffy promoter provide
malaria resistance?
- Plasmodium vivax can't bind to Endothelial cells
- Plasmodium vivax can't bind to Blood Cells
, - Duffy has not effect on malarial resistance
- Reduced Duffy expression is toxic to malarial parasite
Plasmodium vivax - CORRECT ANSWERS- - Plasmodium vivax
can't bind to Blood Cells
For the mutated Duffy cell, there are no visible receptors on the
cell's surface! Additionally, we are talking about RED BLOOD
CELLS ... not endothelial cells (there is no indication that this
impacts endothelial cells).
How does the GA(T>C)A mutation in the Duffy promoter impact
Duffy transcription?
- The transcription factor that binds the GATA enhance doesn't
bind GACA.
- GACA enhancer does not release the transcription factor
- The mutation from T > C blocks Duffy mRNA splicing.
- The mutation from T > C inhibits Duffy mRNA binding to
ribosomes - CORRECT ANSWERS- - The transcription factor that
binds the GATA enhance doesn't bind GACA.
There is a notable change in the gene from GATA to GACA. This
mutation in the gene sequence (at the ENHANCER region) likely
will prevent the transcription factors from interacting with the
gene. Thus, the expression for Duffy will NOT be driven forward.
