NCLEX-RN 2025 Complete Practice Bundle — 100+ High-Yield Questions with Answers & Rationales (All Topics Covered)

NCLEX-RN 2025 COMPLETE PRACTICE BUNDLE

PHARMACOLOGY

1. What is the antidote for heparin overdose?
A. Vitamin K
B. Protamine sulfate
C. Naloxone
D. Acetylcysteine
✔️ Answer: B – Protamine sulfate neutralizes the effects of
heparin.
2. A patient is prescribed digoxin. Which symptom indicates
digoxin toxicity?
A. Tachycardia
B. Constipation
C. Blurred vision with yellow halos
D. Diarrhea
✔️ Answer: C – Yellow-tinged vision is a hallmark of digoxin
toxicity.
3. Which medication should be avoided during pregnancy?
A. Acetaminophen
B. Lisinopril
C. Folic acid
D. Iron supplements
✔️ Answer: B – Lisinopril is an ACE inhibitor, contraindicated
during pregnancy.
4. A nurse is monitoring a patient on furosemide. What lab value is
most important?
A. Hemoglobin
B. Potassium
C. Sodium
D. Calcium
✔️ Answer: B – Furosemide can cause hypokalemia.
5. What is the therapeutic range for lithium?
A. 0.2–0.6 mEq/L
B. 1.5–2.0 mEq/L
C. 0.6–1.2 mEq/L

, D. 2.0–2.5 mEq/L
✔️ Answer: C – Lithium's therapeutic range is 0.6–1.2 mEq/L.

MEDICAL-SURGICAL NURSING

6. A patient with COPD is receiving oxygen. Which finding
requires immediate action?
A. Oxygen flow rate at 2 L/min via nasal cannula
B. Respiratory rate of 10
C. Oxygen saturation of 90%
D. Productive cough with green sputum
✔️ Answer: B – A respiratory rate of 10 may indicate
hypoventilation due to oxygen-induced hypoxia.
7. What is a priority intervention for a patient with chest pain?
A. Administer morphine
B. Check blood glucose
C. Administer a beta-blocker
D. Obtain an ECG
✔️ Answer: D – ECG should be done immediately to assess for
MI.
8. Which lab value indicates renal dysfunction?
A. Sodium 135 mEq/L
B. Potassium 4.1 mEq/L
C. Creatinine 2.5 mg/dL
D. Calcium 9.2 mg/dL
✔️ Answer: C – Elevated creatinine suggests impaired kidney
function.
9. What is a classic symptom of right-sided heart failure?
A. Dyspnea
B. Crackles in lungs
C. Peripheral edema
D. Orthopnea
✔️ Answer: C – Right-sided failure leads to systemic
congestion.
10. In a burn patient, which electrolyte imbalance is most
likely in the first 24 hours?
A. Hyperkalemia
B. Hypokalemia

, C. Hypernatremia
D. Hyponatremia
✔️ Answer: A – Potassium leaks from damaged cells into the
bloodstream.

MATERNAL AND NEWBORN

11. Which intervention is appropriate during the fourth stage
of labor?
A. Monitor uterine tone
B. Encourage ambulation
C. Administer oxytocin
D. Initiate breastfeeding
✔️ Answer: A – Monitoring uterine tone helps identify
postpartum hemorrhage.
12. What is the normal fetal heart rate range?
A. 100–120 bpm
B. 110–160 bpm
C. 120–180 bpm
D. 130–170 bpm
✔️ Answer: B – Normal fetal heart rate is 110–160 bpm.
13. A patient with preeclampsia should be monitored for?
A. Hypotension
B. Proteinuria
C. Bradycardia
D. Constipation
✔️ Answer: B – Proteinuria is a key sign of preeclampsia.
14. When should Rhogam be administered?
A. Immediately after delivery to Rh-negative mothers of Rh-
positive babies
B. During labor
C. At 12 weeks gestation
D. Only if the mother is Rh-positive
✔️ Answer: A – Prevents isoimmunization in Rh-negative
mothers.
15. Which is a danger sign during pregnancy?
A. Nausea in the morning
B. Fetal movement