PART-2 NCLEX-RN Pharmacology Practice Questions with Rationales – 2025 Edition

PART-2

NCLEX-RN Pharmacology Practice Questions
with Rationales – 2025 Edition


26. Which medication should the nurse question for a patient with a sulfa allergy?

 Metoprolol
 Furosemide
 Digoxin
 Acetaminophen
✅ Correct Answer: B. Furosemide
Rationale: Furosemide is a sulfonamide-derived medication. Patients with sulfa
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allergies may have cross-sensitivity and should be monitored or prescribed
alternatives.
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27. What is a priority teaching point for a patient prescribed prednisone?
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 Take on an empty stomach
 Avoid potassium-rich foods
 Do not stop abruptly
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 Use sun protection
✅ Correct Answer: C. Do not stop abruptly
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Rationale: Prednisone is a corticosteroid and should be tapered off gradually to avoid
adrenal insufficiency.



28. Which assessment is most important for a patient taking amiodarone?

 Heart rate
 Blood glucose
 Respiratory status
 Liver enzymes
✅ Correct Answer: C. Respiratory status
Rationale: Amiodarone can cause pulmonary toxicity, including fibrosis. Monitoring
respiratory symptoms is crucial.



29. Which medication may cause gingival hyperplasia as a side effect?

,  Phenytoin
 Carbamazepine
 Valproic acid
 Levetiracetam
✅ Correct Answer: A. Phenytoin
Rationale: Gingival hyperplasia is a common adverse effect of long-term phenytoin
use.



30. What lab value is most important to check before giving a dose of lithium?

 Sodium
 Glucose
 Hemoglobin
 Platelets
✅ Correct Answer: A. Sodium
Rationale: Sodium levels affect lithium excretion. Low sodium can increase the risk
of lithium toxicity.
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31. Which of the following is a serious adverse effect of clozapine?
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 Hypertension
 Agranulocytosis
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 Dry mouth
 Tachycardia
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✅ Correct Answer: B. Agranulocytosis
Rationale: Clozapine can suppress bone marrow, leading to a dangerous drop in
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white blood cells. Monitor WBCs regularly.



32. A patient on isoniazid should be monitored for which nutrient deficiency?

 Calcium
 Vitamin B6
 Iron
 Folic acid
✅ Correct Answer: B. Vitamin B6
Rationale: Isoniazid can cause pyridoxine (vitamin B6) deficiency, leading to
peripheral neuropathy.



33. Which medication requires peak and trough monitoring?

 Vancomycin