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Exam (elaborations)

Pharm HESI Practice Exam 2025–2026 – Real Exam Questions and Verified Correct Answers – Comprehensive NCLEX Pharmacology Review

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This document contains the accurate and fully updated question set from the 2025–2026 Pharm HESI Practice Exam, with verified correct answers and detailed rationales. It includes over 100 real exam-style questions covering essential pharmacologic concepts such as cardiac medications, antibiotics, analgesics, insulin types, anticoagulants, neuro drugs, endocrine treatments, and chemotherapy agents. Clinical decision-making, patient safety, side effects, and priority actions are emphasized throughout. Ideal for nursing students preparing for the HESI exit exam or NCLEX-RN/PN pharmacology sections.

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Institution
Pharm HESI Practic
Course
Pharm HESI Practic

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Uploaded on
May 21, 2025
Number of pages
24
Written in
2024/2025
Type
Exam (elaborations)
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Questions & answers

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Pharm HESI Practice EXAM 2025-2026
QUESTIONS AND CORRECT ANSWERS
ACCURATE REAL EXAM
The nurse admits a client with tumor-induced spinal cord compression. Which
medication should the nurse anticipate to be prescribed to offer the best palliative
treatment for this client?



A. Morphine sulfate.

B. Ibuprofen.

C. Amitriptyline.

D. Dexamethasone. - answer>>>D. Dexamethasone.



The nurse is preparing an education session for a client prescribed opioids for
intractable cancer pain. The nurse should include strategies to help prevent which
common side effect associated with long-term use of opioids?



A. Sedation.

B. Constipation.

C. Urinary retention.

D. Respiratory depression. - answer>>>B. Constipation.

A client with giardiasis is taking metronidazole (Flagyl) 2 grams PO. Which information
should the nurse include in the client's instruction?



A. Notify the clinic of any changes in the color of urine.

B. Avoid overexposure to the sun.

C. Stop the medication after the diarrhea resolves.

D. Take the medication with food. - answer>>>D. Take the medication with food.

,A female client with rheumatoid arthritis takes ibuprofen (Motrin) 600 mg PO 4 times a
day. To prevent gastrointestinal bleeding, misoprostol (Cytotec) 100 mcg PO is
prescribed. Which information is most important for the nurse to include in client
teaching?



A. Use contraception during intercourse.

B. Ensure the Cytotec is taken on an empty stomach.

C. Encourage oral fluid intake to prevent constipation.

D. Take Cytotec 30 minutes prior to Motrin. - answer>>>A. Use contraception during
intercourse.



A client with osteoarthritis receives a new prescription for celecoxib (Celebrex) orally for
symptom management. The nurse notes the client is allergic to sulfa. Which action is
most important for the nurse to implement prior to administering the first dose?



A. Review the client's hemoglobin results.

B. Notify the healthcare provider.

C. Inquire about the reaction to sulfa.

D. Record the client's vital signs. - answer>>>B. Notify the healthcare provider.



A client is admitted to the hospital for a new onset of supraventricular tachycardia (SVT)
and is prescribed digoxin. For which laboratory finding should the nurse notify the
healthcare provider immediately?



A. Potassium level of 3.1 mEq/L.

B. Sodium level of 132 mEq/L.

C. Calcium level of 8.6 mg/dL.

D. Magnesium level of 1.2 mEq/L. - answer>>>A. Potassium level of 3.1 mEq/L.

, The nurse is transcribing a new prescription for spironolactone (Aldactone) for a client
who receives an angiotensin-converting enzyme (ACE) inhibitor. Which action should
the nurse implement?



A. Verify both prescriptions with the healthcare provider.

B. Report the medication interactions to the nurse manager.

C. Hold the ACE inhibitor and give the new prescription.

D. Transcribe and send the prescription to the pharmacy. - answer>>>A. Verify both
prescriptions with the healthcare provider.




A client is prescribed controlled-release oxycodone. Which dosing schedule is best for
the nurse to teach the client?



A. As needed.

B. Every 12 hours.

C. Every 24 hours.

D. Every 4 to 6 hours. - answer>>>B. Every 12 hours.



The nurse is caring for a client who has taken atenolol for 2 years. The healthcare
provider recently changed the medication to enalapril to manage the client's blood
pressure. Which instruction should the nurse provide the client regarding the new
medication?



A. Take the medication at bedtime.

B. Report presence of increased bruising.

C. Check pulse before taking medication.

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