HESI Pharmacology Practice Exam 2025
Questions and Answers
Following the administration of sublingual nitroglycerin to a client experiencing an acute anginal
attack, which assessment finding indicates to the nurse that the desired effect has been achieved?
A. Client states chest pain is relieved
B. Client's pulse decreases from 120 to 90
C. Client's systolic blood pressure decreases from 180 to 90
D. Clients SaO2 level increases from 92% to 96% - ANSWER✔✔-A. nitroglycerin reduces
mycocardial oxygen consumption which decreases ischemia and reduces chest pain
A client with hyperlipidemia recieves a prescription for niacin (niaspan). which client teaching is
most important for the nurse to provide
a. expected duration of flushing
b. symptoms of hyperglycemia
c. diets that minimize gi irritation
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,d. comfort measure for pruritis - ANSWER✔✔-A. flushing of the face and neck, lasting up to an
hour, is a frequent reason for discontinuing niacin. inclusion of this effect in clietn teaching may
promote compliance in taking the med.
When assessing an adolescent who recently overdosed on acetaminophen (tylonel), it is most
important for the nurse to assess for pain in which area of the body
a. flank
b. abdomen
c. chest
d. head - ANSWER✔✔-B. acetaminophen toxicisty an result in liver damage; therefore, it is
especially important for the nurse to assess for pain in the right upper quadrant of the abdomen
(which might indicated liver damage)
A client is admitted to the coronary care unit with a medical diagnosis of acute myocardial
infarction. which medication prescription decreases both preload and afterload
a. nitroglycerin
b. propranolol
c. propranolol
d. captopril - ANSWER✔✔-A. nitroglycerin is a nitrate that causes peripheral vasodilation and
decreases contractility, thereby decreasing both preload and afterload
A client is being treated for hyperthyroidism with propylthiouracil (PTU). The nurse knows that the
action of this drug is to
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,A. decrease the amount of the thyroid-stimulating hormone circulating in the blood
B. increase the amount of thyroid-stimulating hormone circulating in the blood
C. increase the amount of T4 and decrease the amount of T3 produced by the thyroid
D. inhibit synthesis of T3 and T4 by the thyroid gland - ANSWER✔✔-D. PTU is an adjunct
therapy used to control hyperthyroidism by inhibiting production of thyroid hormones. It is often
prescribed in prep for thyroidectomy or radioactive iodine therapy
Which change in data indicates to the nurse the desired effect of the angiotensin II receptor
antagonist has been achieved
A. Dependent edema reduced form +3 to +1
B. Serum HDL increased from 35 to 55mg/dl
C. PUlse rate reduced from 150 to 90 beats/min
D. Blood pressure reducedf rom 160/90 to 130.80 - ANSWER✔✔-D. angiotensin II receptor
antagonist (blocker), prescribed from treatment of HTN. The desired effect is a decrease in blood
pressure.
Which instructions should the nurse give to a female client who just recieved a prescription for oral
metronidazole (flagyl) for treatment of trichomonas vaginalis (select all that apply)
A. increase fluid intake, especially cranberry juice
B. Do not abruptly discontinue the medication; taper use
C. Check blood pressure daily to detect hypertension
D. Avoid drinking alcohol while taking this medication
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, E. Use condoms until treatment is completed
F. Ensure that all sexual partners are treated at the same time - ANSWER✔✔-ADEF
The nurse is transcribing a new prescription for spironolactone (aldactone) for a client who receives
an angiotensin-converting enzyme inhibitor. Which action should the nurse implement
A. verify both prescriptions with the HCP
B. report the med interactions to the nurse manager
C. hold the ACE inhibitor and give the new prescription
D. Transcribe and send the prescription to the pharmacy - ANSWER✔✔-A. the concomitant use of
an ACE inhibitor and a potassium-sparing diuretic sucha s spironolactone, should be given with
caution b/c the two drugs may interact to cause an elevation in serum potassium levels.
A client has myxedema, which results from a deficiency of thyroid hormone synthesis in adults. The
nurse knows that which medication should be contraindicated for this client?
A. liothyronine (cytomel) to replace iodine
B. Furosemide (Lasix) for relief of fluid retention
C. Pentobarbital sodium for sleep
D. nitroglycerin for angina pain - ANSWER✔✔-C. persons with myxedema are dangerously
hypersensitive to narcotics, barbiturates, and anesthetics. They do not tolerate liothyronine and
usually receive iodine replacement therapy. These clients are also suceptable to heart problems such
as angina for which nitroglycerine would be indicated and and congestive heart failure for which
furosemide would be indicated
FOR STUDY PURPOSES ONLY COPYRIGHT © 2025 ALL RIGHTS RESERVED 4
Questions and Answers
Following the administration of sublingual nitroglycerin to a client experiencing an acute anginal
attack, which assessment finding indicates to the nurse that the desired effect has been achieved?
A. Client states chest pain is relieved
B. Client's pulse decreases from 120 to 90
C. Client's systolic blood pressure decreases from 180 to 90
D. Clients SaO2 level increases from 92% to 96% - ANSWER✔✔-A. nitroglycerin reduces
mycocardial oxygen consumption which decreases ischemia and reduces chest pain
A client with hyperlipidemia recieves a prescription for niacin (niaspan). which client teaching is
most important for the nurse to provide
a. expected duration of flushing
b. symptoms of hyperglycemia
c. diets that minimize gi irritation
FOR STUDY PURPOSES ONLY COPYRIGHT © 2025 ALL RIGHTS RESERVED 1
,d. comfort measure for pruritis - ANSWER✔✔-A. flushing of the face and neck, lasting up to an
hour, is a frequent reason for discontinuing niacin. inclusion of this effect in clietn teaching may
promote compliance in taking the med.
When assessing an adolescent who recently overdosed on acetaminophen (tylonel), it is most
important for the nurse to assess for pain in which area of the body
a. flank
b. abdomen
c. chest
d. head - ANSWER✔✔-B. acetaminophen toxicisty an result in liver damage; therefore, it is
especially important for the nurse to assess for pain in the right upper quadrant of the abdomen
(which might indicated liver damage)
A client is admitted to the coronary care unit with a medical diagnosis of acute myocardial
infarction. which medication prescription decreases both preload and afterload
a. nitroglycerin
b. propranolol
c. propranolol
d. captopril - ANSWER✔✔-A. nitroglycerin is a nitrate that causes peripheral vasodilation and
decreases contractility, thereby decreasing both preload and afterload
A client is being treated for hyperthyroidism with propylthiouracil (PTU). The nurse knows that the
action of this drug is to
FOR STUDY PURPOSES ONLY COPYRIGHT © 2025 ALL RIGHTS RESERVED 2
,A. decrease the amount of the thyroid-stimulating hormone circulating in the blood
B. increase the amount of thyroid-stimulating hormone circulating in the blood
C. increase the amount of T4 and decrease the amount of T3 produced by the thyroid
D. inhibit synthesis of T3 and T4 by the thyroid gland - ANSWER✔✔-D. PTU is an adjunct
therapy used to control hyperthyroidism by inhibiting production of thyroid hormones. It is often
prescribed in prep for thyroidectomy or radioactive iodine therapy
Which change in data indicates to the nurse the desired effect of the angiotensin II receptor
antagonist has been achieved
A. Dependent edema reduced form +3 to +1
B. Serum HDL increased from 35 to 55mg/dl
C. PUlse rate reduced from 150 to 90 beats/min
D. Blood pressure reducedf rom 160/90 to 130.80 - ANSWER✔✔-D. angiotensin II receptor
antagonist (blocker), prescribed from treatment of HTN. The desired effect is a decrease in blood
pressure.
Which instructions should the nurse give to a female client who just recieved a prescription for oral
metronidazole (flagyl) for treatment of trichomonas vaginalis (select all that apply)
A. increase fluid intake, especially cranberry juice
B. Do not abruptly discontinue the medication; taper use
C. Check blood pressure daily to detect hypertension
D. Avoid drinking alcohol while taking this medication
FOR STUDY PURPOSES ONLY COPYRIGHT © 2025 ALL RIGHTS RESERVED 3
, E. Use condoms until treatment is completed
F. Ensure that all sexual partners are treated at the same time - ANSWER✔✔-ADEF
The nurse is transcribing a new prescription for spironolactone (aldactone) for a client who receives
an angiotensin-converting enzyme inhibitor. Which action should the nurse implement
A. verify both prescriptions with the HCP
B. report the med interactions to the nurse manager
C. hold the ACE inhibitor and give the new prescription
D. Transcribe and send the prescription to the pharmacy - ANSWER✔✔-A. the concomitant use of
an ACE inhibitor and a potassium-sparing diuretic sucha s spironolactone, should be given with
caution b/c the two drugs may interact to cause an elevation in serum potassium levels.
A client has myxedema, which results from a deficiency of thyroid hormone synthesis in adults. The
nurse knows that which medication should be contraindicated for this client?
A. liothyronine (cytomel) to replace iodine
B. Furosemide (Lasix) for relief of fluid retention
C. Pentobarbital sodium for sleep
D. nitroglycerin for angina pain - ANSWER✔✔-C. persons with myxedema are dangerously
hypersensitive to narcotics, barbiturates, and anesthetics. They do not tolerate liothyronine and
usually receive iodine replacement therapy. These clients are also suceptable to heart problems such
as angina for which nitroglycerine would be indicated and and congestive heart failure for which
furosemide would be indicated
FOR STUDY PURPOSES ONLY COPYRIGHT © 2025 ALL RIGHTS RESERVED 4
