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A 28-year-old with psoriatic arthritis and back pain is receiving
etanercept (Enbrel). Which finding is most important for the
nurse to report to the health care provider?
a. Crackles are heard in both lung bases.
b. Red, scaly patches are noted on the arms.
c. Hemoglobin level is 11.1g/dL and hematocrit is 35%.
d. Patient reports continued back pain after a week of
etanercept therapy. -
ANSWER-ANS: A
Because heart failure is a possible adverse effect of etanercept,
the medication may need to be discontinued. The other
information will also be reported to the health care provider but
does not indicate a need for a change in treatment. Red, scaly
patches of skin and mild anemia are commonly seen with
psoriatic arthritis. Treatment with biologic therapies requires
time to improve symptoms.
,In assessing the joints of a patient with rheumatoid arthritis, the
nurse understands that the joints are damaged by (select all
that apply)
a. bony ankylosis following inflammation of the joints
b. the deterioration of cartilage by proteolytic enzymes
c. the development of Heberden's nodes in the joint capsule
d.. increased cartilage and bony growth at the joint margins
e. invasion of pannus into the joint causing a loss of cartilage -
ANSWER-
Correct answers: A & E
Rationale: Bony ankylosis is the union of the bones of a joint
by proliferation of bone cells, resulting in complete immobility.
Bony ankylosis occurs with advanced rheumatoid arthritis.
Joint changes from chronic inflammation begin when the
hypertrophied synovial membrane invades the surrounding
cartilage, ligaments, tendons, and joint capsule. Pannus (i.e.,
highly vascular granulation tissue) forms within the joint. It
eventually covers and erodes the entire surface of the articular
cartilage. The production of inflammatory cytokines at the
pannus-cartilage junction further contributes to cartilage
destruction. The pannus scars and shortens supporting
structures such as tendons and ligaments, ultimately causing
joint laxity, subluxation, and contracture.
,Assessment data in the patient with osteoarthritis commonly
include?
a. gradual weight loss
b. elevated WBC count
c. joint pain that worsens with use
d. straw-colored synovial fluid - ANSWER-Correct answer: C
Rationale: Osteoarthritis pain ranges from mild discomfort to
significant disability. Joint pain is the predominant symptom,
and the pain generally worsens with joint use.
When administering medications to the patient with gout, the
nurse would recognize which of the following as a treatment for
chronic disease?
a. Colchicine
b. Febuxostat
c. Sulfasalazine
d. Cyclosporine - ANSWER-Correct answer: B
Rationale: Febuxostat (Uloric), a selective inhibitor of xanthine
oxidase, is given for long-term management of hyperuricemia
in persons with chronic gout. Acute gouty arthritis is treated
with colchicine and nonsteroidal antiinflammatory drugs
(NSAIDs).
, In teaching a patient with SLE about the disorder, the nurse
knows that the pathophysiology of SLE includes?
a. circulating immune complexes formed from IgG
autoantibodies reacting with
IgG
b. an autoimmune T-cell reaction that results in destruction of
the deep dermal skin layer
c. immunologic dysfunction leading to chronic inflammation in
the cartilage and muscles
d. the production of a variety of autoantibodies directed against
components of
the cell nucleus - ANSWER-Correct answer: D
Rationale: Systemic lupus erythematosus (SLE) is
characterized by the production of many autoantibodies
against nucleic acids (e.g., single-and double-stranded DNA),
erythrocytes, coagulation proteins, lymphocytes, platelets, and
many other self-proteins. Autoimmune reactions
characteristically are directed against constituents of the cell
nucleus (e.g., antinuclear antibodies [ANAs]), particularly DNA.
Circulating immune complexes containing antibody against
DNA are deposited in the basement membranes of capillaries in
the kidneys, heart, skin, brain, and joints. Complement is
activated, and inflammation occurs. The overaggressive
antibody response is also related to activation of B and T cells.