Where does small cell originate in the lungs? Central airways then to mediastinal nodes
What is another name for small cell? Oat cell
What are some characteristics in SCLC? • Due to smoking
• Metastasizes early
• Fast growing/poor prognosis
Which of the four histological has two stages: limited or extensive? Small Cell (SCLC)
Which lungs CAs are NSCLC? • Large cell
• Adenocarcinoma
• Squamous cell carcinoma
What is the pathophysiology as the tumor enlarges? 1.Nearby airways/alveoli inflame &
swell
2.Alveoli fill with fluid -collapse
3.Nearby blood vessel erode
4.Peripheral tumors invade (pleural space, chest wall, diaphragm)
5.Pleural effusion develops
What are some common complications that arise with lung CA? • Atelectasis
• Pneumonia
• Lung abscess
, What is the most common symptom of lung CA? Cough
What are some clinical manifestations for lung CA? • Asymptomatic
• Cough
• Change in cough and expectorant- first warning
• Blood sputum is common
• Hoarseness (laryngeal nerve compression)
• Facial Edema
• Pneumonia or infection
• Chest pain
• Weight loss
• Weakness & fatigue
• Dyspnea
• Cyanosis
What are the BS associated with lung CA? • Crackle/wheezes- localized where the tumor is
What will the CXR for lung CA reveal? •Majority of tumors can be detected
•Solitary pulmonary nodule or coin lesion is a peripheral lung lesion
•Pleural effusion
What other diagnostic tests could we use? •CT Scan- 4x more accurate in diagnosing CA
than CXR (done for staging)
•MRI
•Sputum cytology
•Bronchoscopy
•Biopsy