Verified Passkey
Which of the types of chemical bonding between drugs and their receptors is the least
common? - Covalent
Which type of drug classification is most important to the practitioner? - Therapeutic
Mechanism of Action - The manner in which molecular targets are affected by the drug
Adverse Drug Reaction (ADR) can lead the patient to - stop taking the drug
Half-life is defined as - The time required for the plasma concentration of a drug to be
reduced by 50 percent
When one drug is more efficacious than another, it has... - A greater ability to initiate a
response
What is bioavailability? - The fraction of unchanged drug that reaches the systemic
circulation following administration by any route
Absorption is defined as: - The transfer of a drug from its site of administration to the
blood
How can Competitive antagonism be overcome? - by adding more agonist
How is children's dosing most often calculated? - MG/KG
A patient complains of pain from a migraine. How would the practitioner classify this type of
pain? - Central Neuropathic Pain
What stage of nociception is occurring when neurotransmitters in the dorsal horn directly or
indirectly depolarize the second-order neurons? - Trasmission
What are the four processes of Nociception - transduction, transmission, modulation,
and perception
A practitioner conducting a pain assessment asks the patient, "Is the pain consistent or
intermittent?" What character of pain is the practitioner assessing? - Temporal pattern
What is the maximum dose of acetaminophen in 24 hours? - 4 grams
, Etodolac is in the same drug class as ibuprofen. What is its mechanism of action? - It
inhibits the cyclooxygenase enzyme.
What kind of drug is Naloxone (Narcan) - opioid antagonist
Acetaminophen and alcohol have a complex relationship in the liver. Why? (3 reasons) -
1. They are both metabolized by the same liver enzyme.
2. Alcohol inhibits the enzyme that metabolizes acetaminophen.
3. The enzyme that metabolizes acetaminophen is induced by alcohol.
What is a contraindication of ibuprofen? - Ulcers
An adverse effect of opiates in elders is... - Bone fractures
Aspirin is different from the other NSAIDs because... - It binds irreversibly to the COX
enzyme
One of the properties that insulins are differentiated by is... - Duration of action
Which form of insulin is the most bioavailable? - Humalog
What is the mechanism of action of sitagliptin (Januvia)? - Slows the inactivation of
incretin hormones by inhibiting dipeptidyl peptidase 4
How does canagliflozin (Invokana) control blood glucose levels? - By reducing glucose
reabsorption in the kidneys
What is the mechanism of action of Lantus? - Insulin precipitates into crystals and is
slowly absorbed over 24 hours
The most common complication of insulin therapy is... - Hypoglycemia
What is the mechanism of action of the sulfonylureas? - Increases insulin secretion
What drug is the first-line therapy for type 2 diabetes? - Metformin
What are the primary symptoms of ketoacidosis? - Excessive thirst and frequent urination
Type 2 diabetes is diagnosed when the A1C value is over: - 6.5%
Description of Type 1 Diabetes - An autoimmune disorder that destroys the beta cells in
the pancreas
Description of Type 2 Diabetes - Insulin resistance and obesity