Verified Questions & Answers for A+
can cause neural tube defects like spina bifida - valproic acid
can cause hepatic necrosis - valproic acid
Carbamazepine (tegretol) FDA - anticonvulsant/mood stabilizer
Carbamazepine (tegretol) Off-label - bipolar depression, bipolar maintenance, psychosis
Carbamazepine (tegretol) 3 main clinical uses - seizures, trigeminal neuralgia, mood
stabilizer
Lamictal (lamotrigine) FDA - mood stabilizer/anticonvulsant
approved for bipolar 1 maintenance
Lamicatal (lamotrigine) off label - bipolar depression, bipolar mania (adjunct and second
line), neuropathic pain, MDD (second line)
Lamictal watch out for - Rash! Stevens Johnson Syndrome
Li 1.5-2.0 - mild to moderate toxicity- vom abd pain dry mouth ataxia slurred speech
dizziness lethargy or excitement muscle weakness
Li 2.0-2.5 - moderate to severe toxicity- anorexia N/V, blurred vision fasciculations, clonic
movements, INCR DTRs, choreoathetoid mvmnts, convulsions delirium syncope EEG chances
stupor coma circulatory failure (arrhyth low BP condxn abn)
Li 2.5 - severe toxicity- convulsions oliguria renal failure death
Li initial labs/monitoring - baseline- serum creatinine, electrolytes, thyroid function (TSH,
T3, T4), CBC, ECG and pregnancy test.
Li continued labs/monitoring - Regular monitoring of serum lithium concentrations is
essential. Lithium levels should be obtained every 2 to 6 months except when there are signs of
toxicity, during dosage adjustments, and in persons suspected to be noncompliant with the
prescribed dosages.
Last dose of li should be approx how many hours prior to lab draw - 12
valproic acid indications - acute mania in bipolar, schizoaffecitve/schizophrenia