Answers | Real Study Quiz
In a primary endocrine pathology, the problem is in the
last endocrine gland (e.g. the adrenal cortex)
anterior pituitary
hypothalamus
posterior pituitary ANS last endocrine gland (e.g. the adrenal cortex)
Cortisol has the following effect(s) on the body
it promotes inflammation
it slows done heart rate
it inhibits inflammation and the immune response
none of these answers are correct ANS it inhibits inflammation and the immune response
In a tertiary endocrine pathology, the problem is in the
hypothalamus
posterior pituitary
last endocrine gland (e.g. the adrenal cortex)
anterior pituitary ANS hypothalamus
In primary adrenal insufficiency, cortisol levels are very low and ACTH levels will be ____'
High because of loss of the negative feedback actions of cortisol
Low because of loss of the negative feedback actions of cortisol ANS High because of loss of the negative
feedback actions of cortisol
Which statement is TRUE?
,ACTH binds to the MC2R receptor. This receptor is expressed in the adrenal cortex
CRH binds to the MC2R receptor to trigger the release of ACTH
None of the above
ACTH is a steroid hormone and is synthesized from cholesterol
ACTH binds to the glucocorticoid receptor. This receptor is expressed in the adrenal cortex ANS ACTH
binds to the MC2R receptor. This receptor is expressed in the adrenal cortex
If there is hyposecretion of cortisol due to the destruction of the adrenal gland, the level of CRH, ACTH, and
cortisol will be ____, respectively
Low; low; low
High; high; high
High; high; low
Low; low; high
High; low; low ANS high high low
In the HPA axis, the following receptor is required for negative feedback exerted by cortisol on the
hypothalamus resulting in lower CRH levels.
melanocortin 2 receptor
glucocorticoid receptor
ACTH receptor
CRH receptor ANS glucocorticoid receptor
In a patient with low cortisol levels, circulating CRH levels are high and ACTH levels are high. This patient
suffers from_____
secondary hypercortisolim
primary hypercortisolism
primary hypocortisolism
secondary hypocortisolism
, tertiary hypocortisolism ANS primary hypocortisolism
If there is hypersecretion of cortisol due to damage to the adrenal cortex, the level of CRH and ACTH will be
_____, respectively
Low; low
High; high
High; low
Low; high ANS low low
If there is hyposecretion of cortisol due to damage to the pituitary, the level of CRH, ACTH, and cortisol will
be ____, respectively
Low; low; low
High; high; high
High; high; low
Low; low; high
High; low; low ANS high low low
If there is hypersecretion of cortisol due to a tumor in the hypothalamus, the level of CRH and ACTH will be
_____, respectively
Low; low
High; high
High; low
Low; high ANS high high
If there is hyposecretion of cortisol due to destruction of the adrenal gland, the level of CRH, ACTH, and
cortisol will be ____, respectively
Low; low; high
Low; low; low