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Class notes Uni4,5 biology

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Concise notes covering topic 7 alevel biology with drawings

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Uploaded on
April 23, 2025
Number of pages
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Written in
2024/2025
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Yahya
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, Ch1 Respiration

① Aerobic Respiration
gen Eqn CH1206
.



602 + >
-
6102 + 6Hz0 (+ energy 36/38 ATP)


3 Steps Glycolysiscutoplasmabs cycle - matrix of Mitochondria
↳ Oxidative phosphorylation -

inner mitochondrial membrane .




① Glycolysis Site =
Cytoplasm
breakdown of glucose in the Cytoplasm producing 2 molecules or pyruvates
Products -> 2ATP & 2 reduced NAD .




Glucose
2ATP
GADP D
Phosphorylation .




Cfructose) Hexose Biphosphate
②lysis
- L

(Gp) Triose P Triose P
+
③ Oxidation (loss at H)
-
dehydrogenase
Iremove H
GNAD
reduced NAD (NADIA
NADT
Dreduced NAD (NADI)
2ADP 2 ADD * ATP synthase
G 2ATP G 2ATP
① ATP formation
pyruvate (39 Pyruvate
* Net gain of 2ATP by substrate level Phosphorylation

②Link Rxn & Krebs Cycle site manix =



2A)linkRyn Pyruvate is decarboxylated Roxidised producing a 2C
-




fragment
(22) acetylgip then cornegie A joins·
acetyl gup producing Acetyl CoA
.




Products = 2 R .

NAD /2CO2


(B) Krebs cycle -
It's a series
decarboxylation Rxns In which 62 acid Citric
of .
a


is converted inter a SLacid
(2-retoglutaric acid) which is
Even converted into a 4C acid (oxaloacetic acid).
=>
This 41 acid is use to
generate
the Glacid (acetyl CoAued)
Products- -G R NAD .


, 2ATD

4202 ,
2 R FAD
.
.

, E pyruvate X2 Total products
NADT
CO2G 10 R NAD
Reduced NAD (NADH)
.




CoenzymeA >
- Link Rxn 2 R FAD
-




of
#
Movement a lot of it ~
caused Alp formation Acetyl CoA GCO2
4 ATD



4 lacid

oxidised
S




R&
-
-
S
Coxabaceric acid


FA
2RNAD
2NAD ATP .
Hrebs Cycle




slavid)
i 2C-Retoglutaric acid)
oxidised
D
Gacid
Citricacid)


So
Oxidized




⑤ Oxidative Phosphorylation


*
gite innner Mitochondrial membrane




① Reduced NAD/FAD are converted into
NADT/FAD+ release the 2H atoms (terminal
,

oxidation). The 2H atoms Split into to 2ed 2H +

② The ze-are picked by an e-acceptor& pass thor an fil in a series of redox Ran
producing
Cytochrome
energy
③ This
energy
is used fo the active
pumping (H + pumps) into intermembrane space.
the

to l +
The inner membrane is impermeable except for a certain channel protein Istalked particles which
contains ATP Synthase)
④ The diffusion of + down electrochemical gradient into matrix thrn stalked particles releases
energy
⑤ Oxygen is the final e- & It acceptor restoring oxidised coenzymes (NAD/FAD) and ETC , forming .
metabolic water

NO has higher affinity /ability to pich upe-sH > NAD/EAD
+
a


Respiration is conmoved by enzymes (intra cellular)
8




#
O
e-acceptors/carriers / l pumps/cytochrome
+ .




N .
B In anaerobic respiration ,
there's no
oxygen.. · FAD/NAD aren't reoxidised , leaving no oxidised
coenzymes to be used in the Link Ran &urbs cycle Corey stop.
In this Respiration
case ,
is limited to
glycolysis which only produces LATP
molecules by substrate level phosphorylation.

, ② Anaerobic Respiration
(A) Lactic acid fermentation
-


Site >
-

muscles of mammals / some type of bacteria

glucose lactic
energy (2ATP)
> acid
-gen egn->
-
.
+


Steps Glucose
-

-




2ADD - No O2 to act as the final +e- acceptor so
(glycolysis) G2ATP ,




Linuron & urebs cycle stop & respiration is limited
2 pyruvate
a pyruvate reductase NADI
to glycolysis .
/hydrogenase G NAD a pyruvate as the final e-ditt accepter,
acts
Reoxidised coenzyme NAD & produces lactate
2 lactic acid .




(B) Akoholic Fermentation
gite> -

plants (roots in
waterlogged soils &jeast -




gen equ .


>
-
alucose zethanol + <02 ·
+
energy (2ATP)
Glucose
- No O2 to act as the final +e- acceptor so
CCAP
,




Linuron & urebs cycle stop & respiration is limited
2 pyruvate to glycolysis .
apyruvate >
-

CO2 pyruvate is decarboxylated producing ethnal ethanal acts as the finale & H +


a
decarboxylase
,




acceptor restoring oxidised NAD/FAD& producing ethanol
2 ethanol .
,
.




NADHe
a ethanal reductase/ SNAD +




hydrogenase
2 ethand

Anaerobic Respiration & Exercise
exercise
·
During , Of demand > Oz supply - anaerobic Res takes place
·



producing lactate
· After exercise ,
lactic acid
produced in muscles is transported in blood to live

· Inside liver cells ,
lactic acid is oxidised back into pyruvate
this Exn > ↑ f
pyruvate >
- diffuse into matrix to enter Link
-


produced
stored liver in the form of
glycogen
in .




This explains why after exercise The B R
,
.



high/deep/rapid to supply enough of
cont to be


repaying Of debt- -
> EPOC (excessive Post-exercise Of consumption)
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