Biology of Cancer - Answers • Cancer has multiple causes
• Involves multiple cell mutations
• Can arise from any cell of the body capable of evading regulatory controls
• Characterised by defective cellular proliferation (cell growth) and defective cellular differentiation (cell
maturation)
What occurs in cancer - Answers 1. . Apoptosis to cell damage
2. Cancer cell division (cancer) to form an uncontrol tumour growth and cell cannot operate the usual
roles of that particular cell
lymphedema - Answers The lost of lymph nodes = the swelling of left over lymph nodes
Apoptosis - Answers the death of cells which occurs as a normal and controlled part of an organism's
growth or development.
Historical analysis - Answers Grading
Extent of Disease - Answers staging
Normal Defence Mechanisms - Answers • Contact inhibition
• Apoptosis
• Immune response
• Pro-oncogenes regulate normal cell processes
, • Tumour suppressor genes suppress growth
Cancer invasions and metastases - Answers • Metastatic is the spread of cancer from initial or primary
site to a distant site
• Multistage process - tumour angiogenesis, mechanical invasions, detaching and invading surrounding
tissue and walls
LEC
• The cells spread and then flow through your blood system
• Break off travel through the blood system and form another type of cancer
• Doesn't know which part of the body it goes to until it metastases and grows
Process of Cancer development - Answers 1. Initiation of cell changes - chemical, radiation, viralise
(can trigger overproduction of white cancer cells = cancer) , genetic
2. Promotion - dietary, obesity, smoking, alcohol, stress.
3. Progression - Increased growth and invasiveness.
( Filaments can irritate the lung tissue which h can form to cancer)
Cancer classification (Anatomic site) - Answers • Tissue is identified by tissue or origin, anatomic site and
behaviour of the tumour
• Carcinoma = tumours of the skin and the mucous membrane
• Lymphoma/Leukaemia = Haematopoietic system