GUARANTEED SUCCESS
Loss of the poly-A tail associated with eukaryotic mRNAs results in: rapid degradation of the
transcript.
The yeast Saccharomyces cerevisiae is particularly useful for genetic analysis of cell cycle
control because: reproduction by budding allows easy identification of stage in cell cycle.
The temperature at which a cell with a temperature-sensitive mutation is unable to survive is
considered the ___________ temperature. Restrictive
The ________ gene controls progression through "start" at the end of G1 in the cell cycle.
CDC28
CDKs, such as CDC28, require the assistance of ____________ to carry out their enzymatic
activity. Cyclin
The retinoblastoma (Rb) protein regulates progression into S phase by regulating ___________
activity. E2F
CDKs associate with cyclins at specific stages of the cell cycle. The CDK subunit is responsible for
phosphorylating a substrate protein, while the cyclin is responsible for: determining which
specific proteins will be phosphorylated.
, Cytoplasmic proteins that relay signals inside the cell are referred to as: Signal transducers
______________________ are mutant forms of normal genes that act dominantly to
predispose a cell to a cancerous phenotype. Oncogene
The human papilloma virus (HPV) carries a gene that functions as an oncogene by inactivating
the p53 protein. The fact that the loss of p53 function is oncogenic suggests that: p53
normally functions to prevent uncontrolled cell division.
Which of the following does not function to reduce the likelihood of a cell becoming cancerous?
Alternative splicing within the nucleus
Glioblastoma multiforme (GBM) is an aggressive cancer caused by alterations in
_________________ in the brain. Glial Cells
Which of the following functions to regulate the G2-to-M transition? Cyclin B
Oncogenes found in viral genome often cause _____________________ when incorporated
into eukaryotic cells. Increased cell proliferation
Which of the following is NOT a taboo on the use of humans in genetics studies. Phenotypic
Studies