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chemoaffinity hypothesis found frog retinal axon guidance depends upon extrinsic chemical
cues; led to discovery of Eph/ephrins as key regulators of axon repulsion
extrinsic chemical cues of chemicals like Eph/ephrins how does the growth cone know
where to go?
the fusion of the caudal half of a sclerotome with the relatively posterior sclerotome's rostral
half following nerve invasion a mature vertebral segment is derived from.....
low motor neuron growth cones preferentially grow through the rostral somite
repelled; Eph/ephrin signaling low motor neuron growth cones are _____ from the caudal
somite by _____
chemoattractants growth cone movement is regulated by.....
neurotrophin-3 (NT3) common chemoattractant for growth cones
Rho GTPases modulate cytoskeleton to. direct growth cone dynamics
, Rho GTPase family members extracellular signals guide growing axons by regulating.....
apoptosis degradation of cellular organelles
necrosis release of intracellular components
Bax pro-death
Bcl-2 pro-life
caspases cysteine-dependent asparate-directed proteases that help degrade intracellular
proteins
nerve growth factor (NGF) a protein that promotes the survival and growth of axons in the
sympathetic nervous system and certain axons in the brain
tropomyosin related kinase A (TrkA) receptor for NGF
neurotrophic hypothesis 1. neurons are initially overproduced
2. neurons undergo a period of naturally occurring, programmed cell death