Name: Score:
60 Multiple choice questions
Term 1 of 60
HLH is often a fatal consequence of Epstein-Barr virus (EBV) infection in boys with
Adenosine deaminase deficiency, which causes severe combined immunodeficiency.
X- linked lymphoproliferative (XLP) syndrome, which is due to mutations in the SH2D1A
gene (encodes SAP protein).
Common variable immunodeficiency, which leads to low antibody production.
Hyper-igm syndrome, which is characterized by high igm levels.
Term 2 of 60
Which subset of dendritic cells produces type I IFN during viral infections?
Mast cells
Plasmacytoid dendritic cells
Neutrophils
Macrophages
Definition 3 of 60
Monocytes
Which selectin is not found on endothelium?
Mature in The tissue (unlike basophils and eosinophils).
Which subset of dendritic cells produces type i ifn during viral infections?
Highly express CD14 and CD16 after further maturation.
,Term 4 of 60
Mast cells can also be activated by:
Most bacterial/viral infections (note the exceptions listed earlier, such as
HIV).
Fever
Steroids
Primary granules contain Charcot-Leyden crystals
Specific/secondary granules contain preformed mediators that include major
basic protein, eosinophil cationic protein, eosinophil peroxidase, and eosinophil-derived
neurotoxin, which are all toxic to surrounding tissue and are released during cytolysis.
Release preformed mediators (<15 minutes) (e.g., histamine, tryptase, chymase, TNF, and
heparin).
Produce and release lipid-derived mediators (~10-30 minutes) after activation via the
arachidonic acid pathway; responsible for late allergic reactions (e.g., PGD2, LTC4, LTB4,
PAF).
Produce and release cytokines and chemokines (hours to days) after activation (eg, IL-3, IL-
4, IL-5, IL-6, IL-8, IL-10, IL-13, GM-CSF, TNFα, MCP-1, MIP- 1α, and RANTES [CCL-5]).
IgG via FcRI; bacterial antigens via TLR 2/6 or 4; C3a or C5a (anaphylatoxins)(MCTC only);
cytokines; neuropeptides; physical stimuli (e.g., heat, pressure); substance P; and drugs
[radiocontrast media; opioids (MCTC only); muscle relaxants].
Definition 5 of 60
B cell development stages
T cell maturation
B cell maturation table
Mast cells subtypes
,Definition 6 of 60
ITP
Primary granules are enlarged in ___, but secondary granules are absent in ___. The exact
mediators in each are less important.
Which subset of dendritic cells produces type I IFN during viral infections?
In which platelet disorder are platelets abnormally large? Hint: Antibodies to platelet's
GP2b3a are also seen.
At which stage does signaling through the pre-B-cell receptor occur?
Definition 7 of 60
Mast cell activation and signaling
mast cell mediators table
B cell maturation table
Mast cells vs basophils
Definition 8 of 60
eosinophils
Highly express cd14 and cd16 after further maturation.
Migrate into tissues via il-8 (cxcl-8), ifn, f-met-leu-phe (fmlp), mip-1,
ltb4, and c5a as well as interactions between sialyl-lewis x, e-/p- selectins, and lfa-1/icam-1.
Migrate to tissue in response to RANTES (CCL-5) and eotaxin
Can be activated by signals, such as ifn and lps (which binds cd14).
, Definition 9 of 60
For MCT, think Tissue.
For MCTC, think Connective Tissue.
Mnemonic P selectins
Epithelial cells
Mast cells subtypes
Mnemonic mast cells
Term 10 of 60
At which stage does signaling through the pre-B-cell receptor occur?
Mast cells
Pre B cell
Neutrophils
Mature B cell
60 Multiple choice questions
Term 1 of 60
HLH is often a fatal consequence of Epstein-Barr virus (EBV) infection in boys with
Adenosine deaminase deficiency, which causes severe combined immunodeficiency.
X- linked lymphoproliferative (XLP) syndrome, which is due to mutations in the SH2D1A
gene (encodes SAP protein).
Common variable immunodeficiency, which leads to low antibody production.
Hyper-igm syndrome, which is characterized by high igm levels.
Term 2 of 60
Which subset of dendritic cells produces type I IFN during viral infections?
Mast cells
Plasmacytoid dendritic cells
Neutrophils
Macrophages
Definition 3 of 60
Monocytes
Which selectin is not found on endothelium?
Mature in The tissue (unlike basophils and eosinophils).
Which subset of dendritic cells produces type i ifn during viral infections?
Highly express CD14 and CD16 after further maturation.
,Term 4 of 60
Mast cells can also be activated by:
Most bacterial/viral infections (note the exceptions listed earlier, such as
HIV).
Fever
Steroids
Primary granules contain Charcot-Leyden crystals
Specific/secondary granules contain preformed mediators that include major
basic protein, eosinophil cationic protein, eosinophil peroxidase, and eosinophil-derived
neurotoxin, which are all toxic to surrounding tissue and are released during cytolysis.
Release preformed mediators (<15 minutes) (e.g., histamine, tryptase, chymase, TNF, and
heparin).
Produce and release lipid-derived mediators (~10-30 minutes) after activation via the
arachidonic acid pathway; responsible for late allergic reactions (e.g., PGD2, LTC4, LTB4,
PAF).
Produce and release cytokines and chemokines (hours to days) after activation (eg, IL-3, IL-
4, IL-5, IL-6, IL-8, IL-10, IL-13, GM-CSF, TNFα, MCP-1, MIP- 1α, and RANTES [CCL-5]).
IgG via FcRI; bacterial antigens via TLR 2/6 or 4; C3a or C5a (anaphylatoxins)(MCTC only);
cytokines; neuropeptides; physical stimuli (e.g., heat, pressure); substance P; and drugs
[radiocontrast media; opioids (MCTC only); muscle relaxants].
Definition 5 of 60
B cell development stages
T cell maturation
B cell maturation table
Mast cells subtypes
,Definition 6 of 60
ITP
Primary granules are enlarged in ___, but secondary granules are absent in ___. The exact
mediators in each are less important.
Which subset of dendritic cells produces type I IFN during viral infections?
In which platelet disorder are platelets abnormally large? Hint: Antibodies to platelet's
GP2b3a are also seen.
At which stage does signaling through the pre-B-cell receptor occur?
Definition 7 of 60
Mast cell activation and signaling
mast cell mediators table
B cell maturation table
Mast cells vs basophils
Definition 8 of 60
eosinophils
Highly express cd14 and cd16 after further maturation.
Migrate into tissues via il-8 (cxcl-8), ifn, f-met-leu-phe (fmlp), mip-1,
ltb4, and c5a as well as interactions between sialyl-lewis x, e-/p- selectins, and lfa-1/icam-1.
Migrate to tissue in response to RANTES (CCL-5) and eotaxin
Can be activated by signals, such as ifn and lps (which binds cd14).
, Definition 9 of 60
For MCT, think Tissue.
For MCTC, think Connective Tissue.
Mnemonic P selectins
Epithelial cells
Mast cells subtypes
Mnemonic mast cells
Term 10 of 60
At which stage does signaling through the pre-B-cell receptor occur?
Mast cells
Pre B cell
Neutrophils
Mature B cell
