TEST BANK
Cellular and Molecular Immunology. 11th Edition
By Abul Abbas, Andrew Lichtman, and Shiv Pillai
All Chapters 1-21| Latest Edition| 2025
TEST BANK
C
LE
ST
BE
,Table of Contents
Chapter 01 Properties and Overview of Immune Responses 1
Chapter 02 Cells and Tissues of the Immune System 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues 6
Chapter 04 Innate Immunity 10
Chapter 05 Antibodies and Antigens 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
Histocompatibility Complex Molecules 20
Chapter 07 Immune Receptors and Signal Transduction 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement 30
C
Chapter 09 Activation of T Lymphocytes 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
LE 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells 42
Chapter 12 B Cell Activation and Antibody Production 46
Chapter 13 Effector Mechanisms of Humoral Immunity 52
ST
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues 56
Chapter 15 Immunologic Tolerance and Autoimmunity 62
BE
Chapter 16 Immunity to Microbes 67
Chapter 17 Transplantation Immunology 72
Chapter 18 Tumor Immunology 77
Chapter 19 Hypersensitivity Disorders 81
Chapter 20 Allergy 86
Chapter 21 Primary and Acquired Immunodeficiencies
,Chapter 01: Properties and Overview of Immune Responses
MULTIPLE CHOICE
1. The principal function of the immune system is:
a. Defense against cancer
b. Repair of injured tissues
c. Defense against microbial infections
d. Prevention of inflammatory diseases
e. Protection against environmental toxins
ANSWER: C
C
The immune system has evolved in the setting of selective pressures imposed by microbial
infections. Although immune responses to cancer may occur, the concept that
LE
“immunosurveillance” against cancer is a principal function of the immune system is
controversial. Repair of injured tissues may be a secondary consequence of the immune
responses and inflammation. Although the immune system has regulatory features that are
needed to prevent excessive inflammation, prevention of inflammatory diseases is not a primary
ST
function. The immune system can protect against microbial toxins, but it generally does not offer
protection against toxins of nonbiologic origin.
BE
2. Which of the following infectious diseases was prevented by the first successful
vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANSWER: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which was against
smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, smallpox
was reported to be eradicated worldwide by a vaccination program. Effective vaccines against
, tetanus toxin, rubella virus, and poliovirus were developed in the 20th century and are widely
used. There is no effective vaccine against Mycobacterium tuberculosis.
3. Which of the following is a unique property of the adaptive immune system?
a. Highly diverse repertoire of specificities for antigens
b. Self-nonself discrimination
c. Recognition of microbial structures by both cell-associated and soluble receptors
d. Protection against viral infections
e. Responses that have the same kinetics and magnitude on repeated exposure to the same
microbe
ANSWER: A
C
LE
Highly diverse repertoires of specificities for antigens are found only in T and B lymphocytes,
which are the central cellular components of the adaptive immune system. Both the innate and
the adaptive immune systems use cell-associated and soluble receptors to recognize microbes,
display some degree of self-nonself discrimination, and protect against viruses. On repeated
ST
exposure to the same microbe, the adaptive immune response becomes more rapid and of greater
magnitude; this is the manifestation of memory.
BE
4. Antibodies and T lymphocytes are the respective mediators of which two types of
immunity?
a. Innate and adaptive
b. Passive and active
c. Specific and nonspecific
d. Humoral and cell-mediated
e. Adult and neonatal
ANSWER: D
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes
produce antibodies, which are the recognition and effector molecules of humoral immune
responses to extracellular pathogens. T cells recognize and promote eradication of intracellular
pathogens in cell-mediated immunity. Passive and active immunity both can be mediated by
Cellular and Molecular Immunology. 11th Edition
By Abul Abbas, Andrew Lichtman, and Shiv Pillai
All Chapters 1-21| Latest Edition| 2025
TEST BANK
C
LE
ST
BE
,Table of Contents
Chapter 01 Properties and Overview of Immune Responses 1
Chapter 02 Cells and Tissues of the Immune System 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues 6
Chapter 04 Innate Immunity 10
Chapter 05 Antibodies and Antigens 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
Histocompatibility Complex Molecules 20
Chapter 07 Immune Receptors and Signal Transduction 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement 30
C
Chapter 09 Activation of T Lymphocytes 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
LE 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells 42
Chapter 12 B Cell Activation and Antibody Production 46
Chapter 13 Effector Mechanisms of Humoral Immunity 52
ST
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues 56
Chapter 15 Immunologic Tolerance and Autoimmunity 62
BE
Chapter 16 Immunity to Microbes 67
Chapter 17 Transplantation Immunology 72
Chapter 18 Tumor Immunology 77
Chapter 19 Hypersensitivity Disorders 81
Chapter 20 Allergy 86
Chapter 21 Primary and Acquired Immunodeficiencies
,Chapter 01: Properties and Overview of Immune Responses
MULTIPLE CHOICE
1. The principal function of the immune system is:
a. Defense against cancer
b. Repair of injured tissues
c. Defense against microbial infections
d. Prevention of inflammatory diseases
e. Protection against environmental toxins
ANSWER: C
C
The immune system has evolved in the setting of selective pressures imposed by microbial
infections. Although immune responses to cancer may occur, the concept that
LE
“immunosurveillance” against cancer is a principal function of the immune system is
controversial. Repair of injured tissues may be a secondary consequence of the immune
responses and inflammation. Although the immune system has regulatory features that are
needed to prevent excessive inflammation, prevention of inflammatory diseases is not a primary
ST
function. The immune system can protect against microbial toxins, but it generally does not offer
protection against toxins of nonbiologic origin.
BE
2. Which of the following infectious diseases was prevented by the first successful
vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANSWER: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which was against
smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, smallpox
was reported to be eradicated worldwide by a vaccination program. Effective vaccines against
, tetanus toxin, rubella virus, and poliovirus were developed in the 20th century and are widely
used. There is no effective vaccine against Mycobacterium tuberculosis.
3. Which of the following is a unique property of the adaptive immune system?
a. Highly diverse repertoire of specificities for antigens
b. Self-nonself discrimination
c. Recognition of microbial structures by both cell-associated and soluble receptors
d. Protection against viral infections
e. Responses that have the same kinetics and magnitude on repeated exposure to the same
microbe
ANSWER: A
C
LE
Highly diverse repertoires of specificities for antigens are found only in T and B lymphocytes,
which are the central cellular components of the adaptive immune system. Both the innate and
the adaptive immune systems use cell-associated and soluble receptors to recognize microbes,
display some degree of self-nonself discrimination, and protect against viruses. On repeated
ST
exposure to the same microbe, the adaptive immune response becomes more rapid and of greater
magnitude; this is the manifestation of memory.
BE
4. Antibodies and T lymphocytes are the respective mediators of which two types of
immunity?
a. Innate and adaptive
b. Passive and active
c. Specific and nonspecific
d. Humoral and cell-mediated
e. Adult and neonatal
ANSWER: D
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes
produce antibodies, which are the recognition and effector molecules of humoral immune
responses to extracellular pathogens. T cells recognize and promote eradication of intracellular
pathogens in cell-mediated immunity. Passive and active immunity both can be mediated by
