TEST BANKq
Cellular and Molecular Immunology
q q q
Abul Abbas, Andrew Lichtman, and Shiv Pillai
q q q q q q
10th Edition
q
,Table of Contents
q q
Chapter q01 qProperties qand qOverview qof qImmune qResponses 1
Chapter q02 qCells qand qTissues qof qthe qImmune qSystem 3
Chapter q03 qLeukocyte qCirculation qand qMigration qInto qTissues 6
Chapter q04 qInnate qImmunity 10
Chapter q05 qAntibodies qand qAntigens 17
Chapter q06 qAntigen qPresentation qto qT qLymphocytes qand qthe qFunctions qof qMajor
Histocompatibility qComplex qMolecules 20
Chapter q07 qImmune qReceptors qand qSignal qTransduction 27
Chapter q08 qLymphocyte qDevelopment qand qAntigen qReceptor qGene qRearrangement 30
Chapter q09 qActivation qof qT qLymphocytes 34
Chapter q10 qDifferentiation qand qFunctions qof qCD4+ qEffector qT qCells 38
Chapter q11 qDifferentiation qand qFunctions qof qCD8+ qEffector qT qCells 42
Chapter q12 qB qCell qActivation qand qAntibody qProduction 46
Chapter q13 qEffector qMechanisms qof qHumoral qImmunity 52
Chapter q14 qSpecialized qImmunity qat qEpithelial qBarriers qand qin qImmune qPrivileged qTissues 56
Chapter q15 qImmunologic qTolerance qand qAutoimmunity 62
Chapter q16 qImmunity qto qMicrobes 67
Chapter q17 qTransplantation qImmunology 72
Chapter q18 qTumor qImmunology 77
Chapter q19 qHypersensitivity qDisorders 81
Chapter q20 qAllergy 86
Chapter q21 qPrimary qand qAcquired qImmunodeficiencies 89
,Chapter q01: qProperties qand qOverview qof qImmune qResponses
Abbas, qLichtman, qand qPillai: qCellular qand qMolecular qImmunology, q10th qEdition
MULTIPLE qCHOICE
1. The qprincipal qfunction qof qthe qimmune qsystem qis:
a. Defense qagainst qcancer
b. Repair qof qinjured qtissues
c. Defense qagainst qmicrobial qinfections
d. Prevention qof qinflammatory qdiseases
e. Protection qagainst qenvironmental qtoxins
ANS: q q C
The qimmune qsystem qhas qevolved qin qthe qsetting qof qselective qpressures qimposed qby
qmicrobial qinfections. qAlthough qimmune qresponses qto qcancer qmay qoccur, qthe qconcept qthat
q“immunosurveillance” qagainst qcancer qis qa qprincipal qfunction qof qthe qimmune qsystem qis
qcontroversial. qRepair qof qinjured qtissues qmay qbe qa qsecondary qconsequence qof qthe qimmune
qresponses qand qinflammation. qAlthough qthe qimmune qsystem qhas qregulatory qfeatures qthat qare
qneeded qto qprevent qexcessive qinflammation, qprevention qof qinflammatory qdiseases qis qnot qa
qprimary qfunction. qThe qimmune qsystem qcan qprotect qagainst qmicrobial qtoxins, qbut qit qgenerally
qdoes qnot qoffer qprotection qagainst qtoxins qof qnonbiologic qorigin.
2. Which qof qthe qfollowing qinfectious qdiseases qwas qprevented qby qthe qfirst
qsuccessful qvaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: q q C
In q1798, qEdward qJenner qreported qthe qfirst qintentional qsuccessful qvaccination, qwhich qwas
qagainst qsmallpox qin qa qboy, qusing qmaterial qfrom qthe qcowpox qpustules qof qa qmilkmaid. qIn
q1980, qsmallpox qwas qreported qto qbe qeradicated qworldwide qby qa qvaccination qprogram.
qEffective qvaccines qagainst qtetanus qtoxin, qrubella qvirus, qand qpoliovirus qwere qdeveloped
qin qthe q20th qcentury qand qare qwidely qused. qThere qis qno qeffective qvaccine qagainst
qMycobacterium qtuberculosis.
3. Which qof qthe qfollowing qis qa qunique qproperty qof qthe qadaptive qimmune qsystem?
a. Highly qdiverse qrepertoire qof qspecificities qfor qantigens
b. Self-nonself qdiscrimination
c. Recognition qof qmicrobial qstructures qby qboth qcell-associated qand qsoluble qreceptors
d. Protection qagainst qviral qinfections
e. Responses qthat qhave qthe qsame qkinetics qand qmagnitude qon qrepeated qexposure qto
qthe qsame qmicrobe
ANS: q q A
, Highly qdiverse qrepertoires qof qspecificities qfor qantigens qare qfound qonly qin qT qand qB
qlymphocytes, qwhich qare qthe qcentral qcellular qcomponents qof qthe qadaptive qimmune
qsystem. qBoth qthe qinnate qand qthe qadaptive qimmune qsystems quse qcell-associated qand
qsoluble qreceptors qto qrecognize qmicrobes, qdisplay qsome qdegree qof qself-nonself
qdiscrimination, qand qprotect qagainst qviruses. qOn qrepeated qexposure qto qthe qsame qmicrobe,
qthe qadaptive qimmune qresponse qbecomes qmore qrapid qand qof qgreater qmagnitude; qthis qis
qthe qmanifestation qof qmemory.
4. Antibodies qand qT qlymphocytes qare qthe qrespective qmediators qof qwhich qtwo qtypes
qof qimmunity?
a. Innate qand qadaptive
b. Passive qand qactive
c. Specific qand qnonspecific
d. Humoral qand qcell-mediated
e. Adult qand qneonatal
ANS: q q D
Both qB qand qT qlymphocytes qare qprincipal qcomponents qof qadaptive qimmunity. qB
qlymphocytes qproduce qantibodies, qwhich qare qthe qrecognition qand qeffector qmolecules qof
qhumoral qimmune qresponses qto qextracellular qpathogens. qT qcells qrecognize qand qpromote
qeradication qof qintracellular qpathogens qin qcell-mediated qimmunity. qPassive qand qactive
qimmunity qboth qcan qbe qmediated qby qeither qB qor qT qlymphocytes. qSpecific qimmunity qis
qanother qterm qfor qadaptive qimmunity. qBoth qB qand qT qlymphocytes qparticipate qin qadult
qadaptive qimmunity qbut qare qstill qdeveloping qin qthe qneonatal qperiod.
5. The qtwo qmajor qfunctional qclasses qof qeffector qT qlymphocytes qare:
a. Helper qT qlymphocytes qand qcytotoxic qT qlymphocytes
b. Natural qkiller qcells qand qcytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. Memory qT qcells qand qeffector qT qcells
d. Helper qcells qand qantigen-presenting qcells
e. Cytotoxic qT qlymphocytes qand qtarget qcells
ANS: q q A
T qcells qcan qbe qclassified qinto qeffector qsubsets qthat qperform qdifferent qeffector qfunctions.
qMost qeffector qT qcells qare qeither qhelper qT qlymphocytes, qwhich qenhance qthe qresponses qof
qother qimmune qcells, qincluding qphagocytes qand qB qcells, qto qinfections, qor qcytotoxic qT
qlymphocytes, qwhich qdirectly qkill qinfected qcells. qNatural qkiller qcells qare qnot qT
qlymphocytes.
Antigen-presenting qcells qusually qare qnot qT qcells. qMemory qT qcells qare qnot qeffector qT qcells.
6. Which qof qthe qfollowing qcell qtypes qis qrequired qfor qall qadaptive qhumoral qimmune qresponses?
a. Natural qkiller qcells
b. Dendritic qcells
c. Cytolytic qT qlymphocytes
d. B qlymphocytes
e. Helper qT qlymphocytes
ANS: q q D
Humoral qimmune qresponses qare qantibody-mediated qimmune qresponses, qand qall qantibodies
qare qmade qby qB qlymphocytes qand qno qother qcell qtype.
Cellular and Molecular Immunology
q q q
Abul Abbas, Andrew Lichtman, and Shiv Pillai
q q q q q q
10th Edition
q
,Table of Contents
q q
Chapter q01 qProperties qand qOverview qof qImmune qResponses 1
Chapter q02 qCells qand qTissues qof qthe qImmune qSystem 3
Chapter q03 qLeukocyte qCirculation qand qMigration qInto qTissues 6
Chapter q04 qInnate qImmunity 10
Chapter q05 qAntibodies qand qAntigens 17
Chapter q06 qAntigen qPresentation qto qT qLymphocytes qand qthe qFunctions qof qMajor
Histocompatibility qComplex qMolecules 20
Chapter q07 qImmune qReceptors qand qSignal qTransduction 27
Chapter q08 qLymphocyte qDevelopment qand qAntigen qReceptor qGene qRearrangement 30
Chapter q09 qActivation qof qT qLymphocytes 34
Chapter q10 qDifferentiation qand qFunctions qof qCD4+ qEffector qT qCells 38
Chapter q11 qDifferentiation qand qFunctions qof qCD8+ qEffector qT qCells 42
Chapter q12 qB qCell qActivation qand qAntibody qProduction 46
Chapter q13 qEffector qMechanisms qof qHumoral qImmunity 52
Chapter q14 qSpecialized qImmunity qat qEpithelial qBarriers qand qin qImmune qPrivileged qTissues 56
Chapter q15 qImmunologic qTolerance qand qAutoimmunity 62
Chapter q16 qImmunity qto qMicrobes 67
Chapter q17 qTransplantation qImmunology 72
Chapter q18 qTumor qImmunology 77
Chapter q19 qHypersensitivity qDisorders 81
Chapter q20 qAllergy 86
Chapter q21 qPrimary qand qAcquired qImmunodeficiencies 89
,Chapter q01: qProperties qand qOverview qof qImmune qResponses
Abbas, qLichtman, qand qPillai: qCellular qand qMolecular qImmunology, q10th qEdition
MULTIPLE qCHOICE
1. The qprincipal qfunction qof qthe qimmune qsystem qis:
a. Defense qagainst qcancer
b. Repair qof qinjured qtissues
c. Defense qagainst qmicrobial qinfections
d. Prevention qof qinflammatory qdiseases
e. Protection qagainst qenvironmental qtoxins
ANS: q q C
The qimmune qsystem qhas qevolved qin qthe qsetting qof qselective qpressures qimposed qby
qmicrobial qinfections. qAlthough qimmune qresponses qto qcancer qmay qoccur, qthe qconcept qthat
q“immunosurveillance” qagainst qcancer qis qa qprincipal qfunction qof qthe qimmune qsystem qis
qcontroversial. qRepair qof qinjured qtissues qmay qbe qa qsecondary qconsequence qof qthe qimmune
qresponses qand qinflammation. qAlthough qthe qimmune qsystem qhas qregulatory qfeatures qthat qare
qneeded qto qprevent qexcessive qinflammation, qprevention qof qinflammatory qdiseases qis qnot qa
qprimary qfunction. qThe qimmune qsystem qcan qprotect qagainst qmicrobial qtoxins, qbut qit qgenerally
qdoes qnot qoffer qprotection qagainst qtoxins qof qnonbiologic qorigin.
2. Which qof qthe qfollowing qinfectious qdiseases qwas qprevented qby qthe qfirst
qsuccessful qvaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: q q C
In q1798, qEdward qJenner qreported qthe qfirst qintentional qsuccessful qvaccination, qwhich qwas
qagainst qsmallpox qin qa qboy, qusing qmaterial qfrom qthe qcowpox qpustules qof qa qmilkmaid. qIn
q1980, qsmallpox qwas qreported qto qbe qeradicated qworldwide qby qa qvaccination qprogram.
qEffective qvaccines qagainst qtetanus qtoxin, qrubella qvirus, qand qpoliovirus qwere qdeveloped
qin qthe q20th qcentury qand qare qwidely qused. qThere qis qno qeffective qvaccine qagainst
qMycobacterium qtuberculosis.
3. Which qof qthe qfollowing qis qa qunique qproperty qof qthe qadaptive qimmune qsystem?
a. Highly qdiverse qrepertoire qof qspecificities qfor qantigens
b. Self-nonself qdiscrimination
c. Recognition qof qmicrobial qstructures qby qboth qcell-associated qand qsoluble qreceptors
d. Protection qagainst qviral qinfections
e. Responses qthat qhave qthe qsame qkinetics qand qmagnitude qon qrepeated qexposure qto
qthe qsame qmicrobe
ANS: q q A
, Highly qdiverse qrepertoires qof qspecificities qfor qantigens qare qfound qonly qin qT qand qB
qlymphocytes, qwhich qare qthe qcentral qcellular qcomponents qof qthe qadaptive qimmune
qsystem. qBoth qthe qinnate qand qthe qadaptive qimmune qsystems quse qcell-associated qand
qsoluble qreceptors qto qrecognize qmicrobes, qdisplay qsome qdegree qof qself-nonself
qdiscrimination, qand qprotect qagainst qviruses. qOn qrepeated qexposure qto qthe qsame qmicrobe,
qthe qadaptive qimmune qresponse qbecomes qmore qrapid qand qof qgreater qmagnitude; qthis qis
qthe qmanifestation qof qmemory.
4. Antibodies qand qT qlymphocytes qare qthe qrespective qmediators qof qwhich qtwo qtypes
qof qimmunity?
a. Innate qand qadaptive
b. Passive qand qactive
c. Specific qand qnonspecific
d. Humoral qand qcell-mediated
e. Adult qand qneonatal
ANS: q q D
Both qB qand qT qlymphocytes qare qprincipal qcomponents qof qadaptive qimmunity. qB
qlymphocytes qproduce qantibodies, qwhich qare qthe qrecognition qand qeffector qmolecules qof
qhumoral qimmune qresponses qto qextracellular qpathogens. qT qcells qrecognize qand qpromote
qeradication qof qintracellular qpathogens qin qcell-mediated qimmunity. qPassive qand qactive
qimmunity qboth qcan qbe qmediated qby qeither qB qor qT qlymphocytes. qSpecific qimmunity qis
qanother qterm qfor qadaptive qimmunity. qBoth qB qand qT qlymphocytes qparticipate qin qadult
qadaptive qimmunity qbut qare qstill qdeveloping qin qthe qneonatal qperiod.
5. The qtwo qmajor qfunctional qclasses qof qeffector qT qlymphocytes qare:
a. Helper qT qlymphocytes qand qcytotoxic qT qlymphocytes
b. Natural qkiller qcells qand qcytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. Memory qT qcells qand qeffector qT qcells
d. Helper qcells qand qantigen-presenting qcells
e. Cytotoxic qT qlymphocytes qand qtarget qcells
ANS: q q A
T qcells qcan qbe qclassified qinto qeffector qsubsets qthat qperform qdifferent qeffector qfunctions.
qMost qeffector qT qcells qare qeither qhelper qT qlymphocytes, qwhich qenhance qthe qresponses qof
qother qimmune qcells, qincluding qphagocytes qand qB qcells, qto qinfections, qor qcytotoxic qT
qlymphocytes, qwhich qdirectly qkill qinfected qcells. qNatural qkiller qcells qare qnot qT
qlymphocytes.
Antigen-presenting qcells qusually qare qnot qT qcells. qMemory qT qcells qare qnot qeffector qT qcells.
6. Which qof qthe qfollowing qcell qtypes qis qrequired qfor qall qadaptive qhumoral qimmune qresponses?
a. Natural qkiller qcells
b. Dendritic qcells
c. Cytolytic qT qlymphocytes
d. B qlymphocytes
e. Helper qT qlymphocytes
ANS: q q D
Humoral qimmune qresponses qare qantibody-mediated qimmune qresponses, qand qall qantibodies
qare qmade qby qB qlymphocytes qand qno qother qcell qtype.
