Advanced Pathophysiology - Wilkes
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,1. Which of the following symptoms is commonly associated with
polycythemia vera (PV)?
- A) Fever and chills
- B) Fatigue and weakness
- C) Red face, hands, feet, ears, headache, drowsiness
- D) Night sweats
Answer: C
Explanation: Polycythemia vera is characterized by increased red blood
cell mass, leading to symptoms such as ruddy complexion, headaches,
dizziness, and drowsiness due to impaired circulation.
2. What laboratory findings are indicative of polycythemia vera?
- A) Decreased erythrocytes and leukocytes
- B) Increased erythrocytes, leukocytes, and platelets
- C) Normal blood cell counts
- D) Decreased hemoglobin levels
Answer: B
Explanation: Patients with polycythemia vera typically exhibit elevated
levels of red blood cells (erythrocytes), white blood cells (leukocytes), and
platelets, reflecting the myeloproliferative nature of the condition.
3. Which myeloproliferative disorder is characterized by increased blood
volume and viscosity?
- A) Essential thrombocythemia
- B) Chronic myeloid leukemia
- C) Polycythemia vera
- D) Myelodysplastic syndrome
,Answer: C
Explanation: Polycythemia vera is known for increased blood cell
production, resulting in elevated blood volume (hypervolemia) and viscosity,
which can lead to complications like thrombosis.
4. A 57-year-old male presents with a red face, headache, and excessive
drowsiness. A blood smear shows increased erythrocytes. What condition
does this indicate?
- A) Iron deficiency anemia
- B) Thrombocytopenia
- C) Polycythemia vera (PV)
- D) Aplastic anemia
Answer: C
Explanation: The described symptoms and laboratory findings are
characteristic of polycythemia vera, a myeloproliferative neoplasm resulting
in excessive erythrocyte production.
5. What symptom is a 67-year-old female patient with polycythemia vera
most likely to report?
- A) Swelling in the lower extremities
- B) Chest pain
- C) Nausea
- D) Coughing
Answer: B
, Explanation: Chest pain is common in patients with polycythemia vera due
to increased blood viscosity, leading to reduced perfusion and potential
ischemic events.
6. What type of inherited disorder are alpha and beta thalassemias classified
as?
- A) X-linked dominant
- B) Autosomal dominant
- C) Autosomal recessive
- D) Multifactorial
Answer: C
Explanation: Both alpha and beta thalassemias are inherited in an
autosomal recessive manner, meaning two copies of the mutated gene are
required for the disease to manifest.
7. The presence of abnormal hemoglobin, specifically Hb S, is characteristic
of which condition?
- A) Sickle Cell Disease
- B) Iron Deficiency Anemia
- C) Thalassemia
- D) Aplastic Anemia
Answer: A
Explanation: Hemoglobin S is an abnormal variant resulting from a genetic
mutation that leads to sickle-shaped red blood cells, characteristic of sickle
cell disease.