PCB 3233 Exam 5 UCF Fall 2025 latest
update correctly answered already
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Memory cells; plasma cells - correct answer Centrocytes can be activated to become what?
Plasma Cells - correct answer _____ can differentiate directly from: Activated B-cells , memory cells
(or memory B cells), or Isotype switched, somatically hypermutated centrocytes.
CR2 - correct answer Binds to complement deposited on the pathogen by way of iC3b and C3d
derivatives of the C3b fragments
CD19 - correct answer Signaling chain of the B-cell co-receptor
CD81 - correct answer Protein that binds to CD19 and is essential in bringing it to the B-cell surface
CR2;CD81(TAPA-1);CD19 - correct answer What are the 3 protein components of the B-cell co-
receptor?
Factor I - correct answer CR1 on B-cell that binds to C3b and becomes susceptible to cleavage by
what?
iC3b;C4d; complement receptor 1 (CR1) - correct answer Factor I first gives what fragment? followed
by what fragment that is more stable? This process enables what to increase ligand abundance for
the B-cell co-receptor on the pathogens surface?
C3d; Lyn ; CD19 - correct answer CR2 binds to what nearby fragment? This brings the B-cell receptor
and co-receptor into juxtaposition setting the stage for the tyrosine kinase what? This is bound to
Igα, to phosphorylate the cytoplasmic tail of what?
B-cell receptor - correct answer Phosphorylated CD19 binds to intracellular signaling molecules that
synergizes with those coming from the ___________
, 1,000-10,000 - correct answer Simultaneous ligation of the B-cell receptor and co-receptor increases
overall signal ______ fold greatly increasing the B-cell's sensitivity to antigen.
infecting pathogen - correct answer Antibodies recruit "destructive, nonspecific" immune system
components to the what?
destroy the pathogen - correct answer Antibodies bind and link the pathogen to effector molecules
or cells that will do what?
NO! Additional signals are required to "activate" a mature naïve B cell - correct answer Is X-linking of
the BCR by Ag sufficient to activate a mature naïve B cell?
Thymus independent antigens - correct answer What does TI mean?
Thymus dependent antigens - correct answer What does TD mean?
DiGeorges syndrome - correct answer Infants with ______________ have no thymus therefore lack T-
cells to help activate TD (Thymus Dependent) B-cells.
thymus transplant - correct answer In DiGeorge syndrome , Infants will die in early childhood unless
given ________________
cross-linking - correct answer B cell activation requires __ of B cell receptors by antigen, which results
in clustering
helper CD4 T cells - correct answer TD antigens activate B cells in the secondary lymphoid tissue
where B cells, specific antigen and helper ____ are brought together
TI-1 - correct answer Bind to BCR and other receptors on B cells, and induces the B cell to proliferate
and differentiate (example LPS binding to TLR)
TI-2 - correct answer Bind to repetitive Antigens and cause extensive cross-linking of BCR's that no
additional signal is needed to activate B-1 cell (override CD14 for help) an example is cell-wall
polysaccharides of streptococcus pneumoniae
update correctly answered already
passed
Memory cells; plasma cells - correct answer Centrocytes can be activated to become what?
Plasma Cells - correct answer _____ can differentiate directly from: Activated B-cells , memory cells
(or memory B cells), or Isotype switched, somatically hypermutated centrocytes.
CR2 - correct answer Binds to complement deposited on the pathogen by way of iC3b and C3d
derivatives of the C3b fragments
CD19 - correct answer Signaling chain of the B-cell co-receptor
CD81 - correct answer Protein that binds to CD19 and is essential in bringing it to the B-cell surface
CR2;CD81(TAPA-1);CD19 - correct answer What are the 3 protein components of the B-cell co-
receptor?
Factor I - correct answer CR1 on B-cell that binds to C3b and becomes susceptible to cleavage by
what?
iC3b;C4d; complement receptor 1 (CR1) - correct answer Factor I first gives what fragment? followed
by what fragment that is more stable? This process enables what to increase ligand abundance for
the B-cell co-receptor on the pathogens surface?
C3d; Lyn ; CD19 - correct answer CR2 binds to what nearby fragment? This brings the B-cell receptor
and co-receptor into juxtaposition setting the stage for the tyrosine kinase what? This is bound to
Igα, to phosphorylate the cytoplasmic tail of what?
B-cell receptor - correct answer Phosphorylated CD19 binds to intracellular signaling molecules that
synergizes with those coming from the ___________
, 1,000-10,000 - correct answer Simultaneous ligation of the B-cell receptor and co-receptor increases
overall signal ______ fold greatly increasing the B-cell's sensitivity to antigen.
infecting pathogen - correct answer Antibodies recruit "destructive, nonspecific" immune system
components to the what?
destroy the pathogen - correct answer Antibodies bind and link the pathogen to effector molecules
or cells that will do what?
NO! Additional signals are required to "activate" a mature naïve B cell - correct answer Is X-linking of
the BCR by Ag sufficient to activate a mature naïve B cell?
Thymus independent antigens - correct answer What does TI mean?
Thymus dependent antigens - correct answer What does TD mean?
DiGeorges syndrome - correct answer Infants with ______________ have no thymus therefore lack T-
cells to help activate TD (Thymus Dependent) B-cells.
thymus transplant - correct answer In DiGeorge syndrome , Infants will die in early childhood unless
given ________________
cross-linking - correct answer B cell activation requires __ of B cell receptors by antigen, which results
in clustering
helper CD4 T cells - correct answer TD antigens activate B cells in the secondary lymphoid tissue
where B cells, specific antigen and helper ____ are brought together
TI-1 - correct answer Bind to BCR and other receptors on B cells, and induces the B cell to proliferate
and differentiate (example LPS binding to TLR)
TI-2 - correct answer Bind to repetitive Antigens and cause extensive cross-linking of BCR's that no
additional signal is needed to activate B-1 cell (override CD14 for help) an example is cell-wall
polysaccharides of streptococcus pneumoniae
