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Bioinformatics - 🧠 ANSWER ✔✔Interdisciplinary field of science developing
methods and software tools
What does bioinformatics do? - 🧠 ANSWER ✔✔It makes diverse, and
complex life sciences data more understandable and useful
Bioinformatics has more emphasis on - 🧠 ANSWER ✔✔More emphasis on
analysis of high-throughput data(e.g., genomic sequence data)
Rapidly Growing field - 🧠 ANSWER ✔✔Field of bioinformatics experiencing
fast growth
Computational Biology - 🧠 ANSWER ✔✔- The application of mathematical
and computational tools to solve biological problems.
- Is the subsequent process of analyzing and interpreting data
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,- Use of mathematical modeling and computational simulations to
understand biological systems and relationships
Computational Biology spans - 🧠 ANSWER ✔✔numerous disciplines:
Genomics,molecular biology, biophysics, ecology, more
Biol 266 will cover - 🧠 ANSWER ✔✔computational biology with an
emphasis on bioinformatics
Bioinformatics in relation to computational biology - 🧠 ANSWER ✔✔is a
subset of computational biology
Two important sub-disciplines in computational biology - 🧠 ANSWER ✔✔-
Algorithm and tool development
- Tool use/application
Algorithm and tool definitions - 🧠 ANSWER ✔✔-Algorithm: a set of rules or
instructions specifying how to solve a problem
- Tool: implementation of that algorithm (software)
Subtasks of computational biology - 🧠 ANSWER ✔✔Pattern discovery:
Learn patterns from biological data Prediction:Use patterns to predict
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,biological function Integration : Develop models that connect levels of
information
Simulation: Model behavior of biological systems on a computer
Engineering: Design novel biological systems for specific purposes
Therapeutics: Design molecular therapeutics to combat disease
wet lab vs dry lab - 🧠 ANSWER ✔✔Wet lab: actual experiments; Data
generation Testing Interpretation
Dry lab: computational: Prediction Model building Hypothesis-generation
Some questions that computational biology can help answer - 🧠 ANSWER
✔✔Given a genetic sequence, what does the gene (protein) do?- Why
does a protein function the way it does?
-How are a group of organisms related?
-How have some microbes evolved to become pathogenic?◦ E.g., origin of
SARS-CoV-2
-How does a particular drug bind to its receptor?
- What is different about tumor versus healthy tissue?
- What is genetically unique about humans?
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, different units in biol 166/ different analysis - 🧠 ANSWER ✔✔Sequence
analysis: How do we determine the optimal alignment between sequences?
& How do we search databases for homologs?
Phylogenetic analysis: How do we organize sequences according totheir
evolutionary relationships?
Structural bioinformatics: How do we model the 3D structure of
abiomolecule to better understand itsfunction?
Genome analysis: How do we find/analyze genes within thecontext of an
entire genome?
Transcriptomics andProteomics: How do weexamine levels ofgene or
protein expression?
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