University Of Central Florida | PCB 3233 immunology test 1 KEY| 2025/2026

University Of Central Florida | PCB 3233 immunology test 1 KEY| 2025/2026 1) Which of the following may be used to describe a B cell receptor? 1. BCR 2. Immunoglobulin 3. Membrane-bound antibody 4. A&B 5. A, B, & C 2) True or False: Commensal bacteria are harmful to our body. Commensal bacteria are helpful... killed by antibiotics (as they cannot distinguish between good and bad) 3) What lymphocyte has the most dark-staining granules? 1. Basophils 2. Eosinophils 3. Neutrophils 4. A, B, & C 5. None of the above... granulocytes are NOT lymphocytes (B-cells, Tcells, NK-cells, ILC’s) 4) List and describe the different types of immunity. Innate- NO memory, fast, always active, some specificity (not as much as adaptive), it’s inherited (DOESN’T change), leads to inflammation, use different receptors Adaptive- has memory, it changes over time, primary immune response (7 days) and secondary immune response (about 4 days), highly specific, Bcells and T-cells involved, uses either a BCR or TCR... not many receptors 5) True or False: Basophils are the LEAST abundant type of leukocyte present in the blood. MOST abundant is Neutrophils (really good phagocytic cells... short-lived) 6) Which PAMP would you expect to see in a Shigella microbe? 1. Teichoic acid (gram positive... look for t in word) 2. Lipoteichoic acid (gram positive... look for t in word) 3. Lipopolysaccharides(gramnegative) 4. A&B 5. A, B, & C This study source was downloaded by from CourseH on :59:39 GMT -05:00 1. The person would control infection for a very short period of time 2. The person would control infection for a very long period of time 3. The person would control infection but not be able to clear it 4. The person would not be able to control the infection (innate activates the adaptive... would much rather have innate if you could only choose one) 8) What is the main function of dendritic cells? 1. Present antigen to T cells ONLY cell that can activate a naïve (never been activated) T- cell... reservoir of antigen for T-cells... reservoir of antigen for B-cells are FDC (follicular dendritic cells present in the follicle) 2. Present antigen to B cells 3. Promotephagocytosis 4. None of the above 10) What is the precursor for ILC’s? 1. Common lymphoid precursor 2. There is no known precursor 3. Common myeloid precursor 4. None of the above 11) True or False: ALL leukocytes are lymphocytes. Leukocytes are WBC’s... NOT just lymphocytes (we have granulocytes and other WBC’s) 12) What type of immunity are NK cells associated with? 1. Innate 2. Adaptive (only involves B-cells and T-cells) 3. A&B 4. None of the above 13) What is the main difference between monocytes and macrophages? 1. Monocytes are phagocytic, whereas macrophages are not 2. Monocytes are located in peripheral blood 3. Macrophages are located in tissues 4. A&B 5. B & C 14) Which granulocyte is primarily known for its phagocytic purpose? This study source was downloaded by from CourseH on :59:39 GMT -05:00 B. Eosinophils C. Neutrophils D. Macrophages 15) True or False: The site of Hematopoiesis is consistent after 9 months since birth. it takes place in the bone marrow pretty much since we are born. Just know 16) The following shows the process of phagocytosis randomly. Arrange them in the correct order. II, IV, I, V, III I. Phagosome fuses with lysosome II. Bacterium becomes attached to membrane envaginations called pseudopodia III. Digestion products are released from cell IV. Bacteria is ingested, forming phagosome V. Lysosomal enzymes digest captured material 17) True or False: The innate immune system activates the adaptive immune system by generating large amounts of immunoglobulins and TCR’s. Immunoglobulins and TCR’s are produced in the adaptive immune system. Innate activates the adaptive with dendritic cells and FDC’s. 18) What is the gold standard of vaccination? 1. Neutralization... neutralization is surrounding the pathogen with antibodies to prevent it from causing harm to us 2. Opsonization... opsonization is surrounding the pathogen with opsonins so that it can be phagocytosed 3. A&B 4. None of the above 19) Which of the following are considered primary lymphoid tissue? 1. Lymph nodes 2. Bonemarrow...B-cellsmaturehere 3. Thymus...T-cellsmaturehere 4. B & C 5. A, B, & C 20) True or False: B cells mature in bone marrow, while T cells mature in the thymus. 21) True or False: The innate immune system is ineffective and not so important. 22) How can pathogens infect/interact with cells? This study source was downloaded by from CourseH on :59:39 GMT -05:00 2. Extracellularly only 3. Intracellularly and extracellularly Model intracellular pathogen is a virus... model extracellular pathogen is bacteria 4. None of the above 23) How are intracellular pathogens located in the nucleus/cytosol different from pathogens located in the vesicles of the cell? A. There is no difference C. Intracellular pathogens located in the vesicles are attacked by killing the infected cell, while intracellular pathogens located in the nucleus/cytosol are attacked by the infected cell by increasing antimicrobial activity D. Pathogens located in the vesicles tend to be weaker than those located in the nucleus/cytosol 24) Why is complement so important? 1. It helps tag pathogens and extracellular molecules for destruction 2. Can destroy pathogens directly by poking holes in the outer membrane or cell wall 3. It is not important, quite irrelevant in fact 4. A&B 25) What is the main role of C3a? 1. To tag pathogens for destruction 2. To recruit phagocytes... C3a serves two main functions: anaphylatoxin (leads to inflammation) and also a chemoattractant (recruits cells to site of infection) 3. A&B B. Intracellular pathogens located in the nucleus/cytosol are attacked by killing the infected cell, while intracellular pathogens located in the vesicles are attacked by the infected cell This study source was downloaded by from CourseH on :59:39 GMT -05:00 D. None of the above 26) Which of the following is true regarding complement? 1. It is ubiquitous in blood and lymph 2. Involves soluble proteases called zymogens 3. It’s a molecular defense that can be used immediately 4. A, B, & C 27) What type of bond is exposed upon cleavage of C3? 1. Carbon single bond 2. Carbon double bond 3. Thioester bond 4. Thioether bond 28) True or False: iC3Bb is the product of C3 hydrolysis. iC3Bb is the soluble C3 convertase of the alternative pathway. 29) True or False: Factor D cleaves Factor B into Bb and Ba. 30) What is the C3 convertase of the alternative pathway? A. C3b B. iC3 C. iC3Bb D. C3bBb 31) True or False: A C3 convertase can only produce 1 C3b. A bunch of C3bs are produced... each can become a C3 convertase if Factor B and Factor D bind to it. 32) What recognizes C3b and promotes phagocytosis upon this recognition? 1. CR1... recognizes C3b 2. CR2... recognizes C3d 3. CR3... recognizes iC3b 4. CR4... recognizes iC3b 33) ___ is the C5 convertase for the alternative pathway, while ___ is the C5 convertase for the classical pathway 1. C4b2a3b ; C3b2Bb This study source was downloaded by from CourseH on :59:39 GMT -05:00 respective pathway 3. C3bBb ; iC3Bb 4. iC3Bb ; C3bBb 34) What is the main role of C5a? 1. Recruit basophils to site of infection 2. Recruit eosinophils to site of infection 3. Recruit Neutrophils to site of infection 4. None of the above 35) True or False: Complement components C5-C9 assemble a complex that pokes a hole on a human’s cell. 36) Which of the following is true regarding complement receptors? 1. CR1 recognizes C3b 2. CR1 recognizes C3bBb 3. CR2 recognizes C3d 4. CR3 and CR4 recognize iC3b 5. A, C, & D 37) True or False: C3a and C5a are referred to as anaphylatoxins and contribute to acute inflammation. 38) True or False: DAF and MCP stop complement pathway in human cells. 39) What are the two main types of defensins and what difference can be noted between these two? 2. a-defensins and b-defensins; b-defensins are produced by neutrophils and Paneth cells, while a-defensins are produced by epithelial cells 3. a-defensins and b-defensins; there is no known differences between these two types of defensins 4. d-defensins and e-defensins; d-defensins are produced by neutrophils and Paneth cells, while e-defensins are produced by epithelial cells 40) What is the protease inhibitor that “baits” proteases and prevents them from causing any damage? A. a2-macroglobulin B. b2-macroglobulin C. d2-macroglobulin D. It has no known name This study source was downloaded by from CourseH on :59:39 GMT -05:00 Paneth cells, while b-defensins are produced by epithelial cells 41) Which of the following is true regarding a C-reactive protein? 1. Binds to phosphorylcholine component of LPS of bacterial/fungal cell walls 2. Binds to phosphorylcholine component of human cells 3. Acts as an opsonin 4. Can bind to C1q to initiate classical complement pathway 5. A, C, & D... CRP is made in the liver (called acute phase reactant) 42) What does MASP-2 cleave? 1. C1 and C2 2. C2 and C3 3. C2 and C4 4. C3 and C4 43) What is the C3 convertase of the classical pathway? A. C3bBb B. C4b2a3b C. C4b2a D. C4bC2a 44) True or False: MASP-2 and C1s are the proteases that cleave C4 in the lectin and classical pathway. 45) True or False: C1r is activated when 1 IgM or 2 IgG’s bind to C1q. 46) What are Kupffer cells? 1. Phagocytic cells of the brain... these are Microglia 2. Phagocytic cells of the bone marrow 3. Phagocytic cells of the thymus 4. Phagocytic cells of the liver 47) MHC I presents peptides from ___ pathogens, whereas MHC II presents peptides from ___ pathogens 1. Bacterial, viral 2. Viral, bacterial 3. Intracellular, extracellular This study source was downloaded by from CourseH on :59:39 GMT -05:00 48) MHC I binds to ___ T-cells, whereas MHC II binds to ___ T-cells 1. CD8, CD4 2. CD4, CD8 3. DC, FDC 4. FDC, DC 49) How many tests are dropped in this class? A. 1 B. 2 C. 3 D. 4 50) What’s the best way of communication with Professor Weigel or Katherine? A. Webcourses email B. Knightsemail C. Call/text D. Don’t communicate with them This study source was downloaded by from