University Of Central Florida | PCB3233/PCB 3233 Module 1 Exam Review

University Of Central Florida | PCB3233/PCB 3233 Module 1 Exam Review The (Unofficial) PCB 3233 Module 1 Exam Review These questions have NOT been reviewed by Prof. Weigel. Please use all your resources to prepare for your exam. Microbe Sheet 1. What is a PRR? What is a PAMP? Do we have PRRs or PAMPs? 2. What is the structure present on a Gram-positive bacterium? Is this a PRR or PAMP? 3. What is the structure present on a Gram-negative bacterium? Is this a PRR or PAMP? 4. What are the examples of Gram-negative bacteria? 5. What are the examples of Gram-positive bacteria? 6. What are some examples of viruses? Chapter 1 7. What is the “model” that we use for intracellular microbes? What about extracellular microbes? 8. What is the lag time for the primary immune response? 9. Select the right option: The first/second infection is the most dangerous. 10.Disease can be prevented by prior exposure from a ____________. 11.Who is considered the Father of Immunology? What did he do? 12.What is the only eradicated (human) pathogen? 13.Any organism with potential to cause disease is a _______________. 14.What is an opportunistic pathogen? 15.What are the four types of pathogens? 16.Select the right options: Commensal bacteria are/are not harmful and can/cannot be killed from a round of antibiotics. 17.What are the physical barriers that we have against infection? 18.What are the two parts of the innate response? 19.What are the four parts of inflammation? 20.Determine if the following statements refers to innate immunity or adaptive immunity. a. Highly specific for antigens b. Includes B and T cells c. Works rapidly d. Remembers a previous microbe e. Give rise to acute inflammatory response f. Uses one type of receptor to recognize different pathogens g. First line of defense This study source was downloaded by from CourseH on :44:15 GMT -05:00 response. 22.T or F: A single lymphocyte will have a receptor with a single specificity. 23.What is clonal selection? What is clonal expansion? 24.Are we more likely to survive if we lose our innate immune system or adaptive immune system? 25.What are leukocytes? What are the cells of the immune system? 26.Are all lymphocytes leukocytes? 27.Where does hematopoiesis occur? 28.Hematopoietic stem cells give rise to other cells through _______________, becoming more mature stem cells that commit to different lineages. 29.What does the lymphoid lineage differentiate into? 30.What does the myeloid lineage differentiate into? 31.What does the erythroid lineage differentiate into? 32.What are the granulocytes? What do they stain 33.What is the most abundant leukocyte? What is the second most abundant? 34.What are the lymphocytes? 35.Are all leukocytes lymphocytes? 36.What do we call resting lymphocytes that have not been activated or interacted with an antigen? 37._______________ are lymphocytes that have interacted with antigen and proliferate and ______________ ______ are lymphocytes that eliminate the antigen. 38.Natural killer (NK) cells are _____________ lymphocytes found mainly in _____________. They secrete ______________ to prevent viruses and activate cell-mediated immunity. 39.Which of the following is NOT true regarding neutrophils? a. They are short-lived and die at the site of infection. b. They are pyogenic. c. They are important lymphocytes with phagocytic ability. d. They are a type of granulocyte. e. All of the above are true. 40.Monocytes circulate in the _________ for about 8 hours, then migrate into the _________ to become _________________. Both are phagocytic. 41.What is the role of a dendritic cell? 42.What is a follicular dendritic cell? 43.Mast cells release mediators such as _____________ which can cause vasodilation and attract leukocytes. 44.Match the following: A. Basophils 1. Allergic reactions, lowest WBCs in circulation B. Neutrophils 2. Responsible for fighting parasites This study source was downloaded by from CourseH on :44:15 GMT -05:00 45.Megakaryocyte is a bone marrow cell responsible for the production of blood _________ when its cytoplasm becomes fragmented. 46.What is another term for erythrocytes? One main difference between erythrocytes and all other cells is that erythrocytes do not have what? 47.Phagocytic cells in the liver are called _________________ while phagocytic cells in the brain are called _________________. 48.What are the four stages of phagocytosis? 49.What is opsonization? 50.Phagosome + lysosome = _______________ 51.When the bacterial component helps send a signal to the macrophage’s nucleus, inflammatory _______________ can be secreted into extracellular space. 52.Are all cytokines chemokines? 53.Which of the following is able to secrete IL-4 and IL-5? a. NK cell b. ILC2 c. TH17 CD4 cell d. ILC3 e. CD8 T cell 54.A(n) ____________ is the specific part of an antigen that can be recognized by BCRs and TCRs. 55.Select the right option: Antibodies/immunoglobulins are part of cellmediated/humoral immunity. 56.What does MHC stand for? What is its purpose? 57.Determine if the following refers to MHC I or MHC II. a. Present in PAPCs b. Extracellular pathogens c. Nucleated cells d. CD4 T cells e. Intracellular pathogens f. CD8 T cells 58.What are the PAPCs? 59.What are the main functions of antibodies? 60.Primary lymphoid tissues- 61.Secondary lymphoid tissues- 62.Antigens are carried to _______ ______, as are lymphocytes, enabling interactions. Pathogen drain from site of infection to here via ____________ lymphatic vessels and leave through _______________ vessels. 63.What do “swollen glands” indicate? 64.Effector B cells secrete ___________. 65.As lymphocyte activation proceeds, follicle shape changes - ________________ This study source was downloaded by from CourseH on :44:15 GMT -05:00 67.What is MALT? 68.What is the basis of vaccination? Chapters 2 + 3 69.T or F: The innate immune system is not very effective. 70.Select the right option: Anthrax is an example of a spore, which is resistant/sensitive to heat and desiccation. 71.The components of complement are made in the ________ and found throughout the blood, lymph, and ECF. 72.What is the order of the complement pathways? 73.Which complement pathway is always “running”? 74.Draw the three complement pathways. 75.Describe the characteristics/functions of the following complement components: a. iC3Bb b. C3bBb c. C3b, C4b, iC3b d. C3a/C5a e. Factor B f. Factor D g. C3b2Bb h. MASP I and MASP II i. CR1 j. CR3 and CR4 k. C4b2a3b l. C4b2a m. MAC n. C1s o. Factor P p. IgG q. IgM r. Factor H and Factor I s. C-reactive protein t. DAF u. MCP v. MBL w. CR2 76.What is the protease inhibitor you need to know? Miscellaneous 77.You get the following scores on your exams: 90, 90, 0, 90, 90. Do you need to take the final exam to get an A in the class? 79.What is the name of your TA? 80.T or F: If you are in the online section, you can take the exam in-person.