Strasinger AUBF - Renal diseases (Glomerular disease book based) Questions and Answers

Strasinger AUBF - Renal diseases
(Glomerular disease book based) Questions
and Answers

Wegener Granulomatosis Correct Ans-Demonstrationof antineutrophilic cytoplasmic antibody

(ANCA) in serum is the key diagnosis




Wegener Granulomatosis Correct Ans-Patients present with pulmonary symptoms and later

develop renal involvement, hematuria, proteinuria RBC casts and elevated serum creatinine and

BUN




Testing for ANCA Correct Ans-Includes incubating serum with either ethanol or

formalin/formaldehyde-fixed neutrophils and examining the preparation using indirect

immunofixation to detect the serum antibodies attached to neutrophils




p-ANCA Correct Ans-Perinuclear pattern formed by the antibodies, formed when neutrophils

are ethanol fixed




c-ANCA Correct Ans-Granularr pattern throughout the cytoplasm when neutrophils are

formalin fixed

, Children Correct Ans-Henoch-Schonlein Purpura occurs primarily in ____ after upper

respiratory infections




Henoch-Schonlein Purpura Correct Ans-Symptoms include appearance of raised, red patches

on the skin, blood in sputum and stool




Membranous Glomerulonephritis Correct Ans-Thrombosis may also occur




Membranous Glomerulonephritis Correct Ans-Lab findings: microscopic hematuria and

elevated urine protein excretion




Type 1 MPGN Correct Ans-Patients progress to nephrotic syndrome




Type 2 MPGN Correct Ans-Patients experience symptoms of chronic glomerulonephritis




Membranoproliferative Glomerulonephritis Correct Ans-Lab findings: hematuria, proteinuria,

and decreased serum complement levels