, Test Bank j2
to accompany
j2
Psychopharmacology, fourth Edition j2 j2
Meyer • Quenzer j2 j2
Chapter 1: Principles of Pharmacology j2 j2 j2 j2
Multiple Choice j2
1. refer(s) to specific molecular changes that occur when a drug binds to a pa j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
rticular target site or receptor, while
j2 j2 j2 j2 j2
are the resulting despread alterations in function.
j2 j2 j2j2 j2 j2 j2
a. Drug action; therapeutic effects
j2 j2 j2
b. Side effects; drug effects
j2 j2 j2
c. Therapeutic effects; side effects j2 j2 j2
d. Drug action; drug effects
j2 j2 j2
Answer: d j2
Textbook Reference: Pharmacology: The Science of Drug Action
j2 j2 j2 j2 j2 j2 j2
2. After drug administration has occurred, the amount of drug in the blood that is free to
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
bind at specific target sites is referred to as
j2 j2 j2 j2 j2 j2 j2 j2
a. the therapeutic dose.
j2 j2
b. first-pass effects. j2
c. bioavailability.
d. ED50.
Answer: c j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
3. The specific molecular changes that occur when a drug binds to a particular target site
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
or receptor are referred to as
j2 j2 j2 j2 j2
a. drug effects. j2
b. drug action. j2
c. side effects. j2
d. placebo effects. j2
Answer: b j2
Textbook Reference: Pharmacology: The Science of Drug Action
j2 j2 j2 j2 j2 j2 j2
4. Which of the follo ng is not a possible explanation for placebo effects?
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. Pavlovian conditioning j2
b. Genetic variation j2
c. Drug competition j2
d. Expectation of outcome j2 j2
Answer: c j2
Textbook Reference: Pharmacology: The Science of Drug Action
j2 j2 j2 j2 j2 j2 j2
Page 1 of 247
j2 j2 j2
,5. The administration of oxytocin has been proposed as a treatment for autism. j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
6. Which factor does not affect the pharmacokinetics of a drug?
j2 j2 j2 j2 j2 j2 j2 j2 j2
a. Route of administration
j2 j2
b. Lipid solubility
j2
c. Depot binding j2
d. Drug action
j2
Answer: d j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
7. First-pass metabolism occurs when drugs are taken
j2 j2 j2 j2 j2 j2
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
8. The area postrema is one area in the brain where the
j2 j2 is not complete.
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. cerebrospinal fluid j2
b. blood–brain barrier j2
c. choroid plexus j2
d. phospholipid membrane j2
Answer: b j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
9. First-pass metabolism occurs th orally administered drugs because
j2 j2 j2j2 j2 j2 j2 j2
a. their absorption is slowed by food.
j2 j2 j2 j2 j2
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j
general circulation.
2 j2
c. drugs must first survive the acidic environment of the stomach.
j2 j2 j2 j2 j2 j2 j2 j2 j2
d. salivary enzymes in the mouth begin the process of metabolism.
j2 j2 j2 j2 j2 j2 j2 j2 j2
Answer: b j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
10. Toxic substances in the blood trigger a vomiting response by activating the
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. blood–brain barrier. j2
b. choroid plexus. j2
c. area postrema.
j2
d. median eminence. j2
Page 2 of 247
j2 j2 j2
, Answer: c j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
11. Drugs administered _ have the most rapid onset of action.
j2 j2 j2 j2 j2 j2 j2 j2
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
12. Ionization of a drug depends on the of the solution and the
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
of the drug.
j2 j2
a. pH; pKa
j2
b. pKa; pH j2
c. concentration; lipid solubility j2 j2
d. pH; concentration
j2
Answer: a j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
13. The absorption of a drug depends on all of the follo ng except
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. lipid solubility.
j2
b. ionization.
c. body temperature.
j2
d. the concentration of the drug.
j2 j2 j2 j2
Answer: c j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
14. Drugs that are should be avoided by women of childbearing age.
j2 j2 j2 j2 j2 j2 j2 j2 j2
a. teratogenic
b. able to cross the placental barrier
j2 j2 j2 j2 j2
c. psychoactive
d. highly lipid-soluble j2
Answer: a j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
15. Agents that induce developmental abnormalities in a fetus are known as
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. psychoactive drugs. j2
b. illicit drugs. j2
c. teratogens.
d. placental drugs. j2
Answer: c j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
16. Depot binding is said to occur when drugs
j2 j2 j2 j2 j2 j2 j2
a. bind to their target sites.
j2 j2 j2 j2
Page 3 of 247
j2 j2 j2
to accompany
j2
Psychopharmacology, fourth Edition j2 j2
Meyer • Quenzer j2 j2
Chapter 1: Principles of Pharmacology j2 j2 j2 j2
Multiple Choice j2
1. refer(s) to specific molecular changes that occur when a drug binds to a pa j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
rticular target site or receptor, while
j2 j2 j2 j2 j2
are the resulting despread alterations in function.
j2 j2 j2j2 j2 j2 j2
a. Drug action; therapeutic effects
j2 j2 j2
b. Side effects; drug effects
j2 j2 j2
c. Therapeutic effects; side effects j2 j2 j2
d. Drug action; drug effects
j2 j2 j2
Answer: d j2
Textbook Reference: Pharmacology: The Science of Drug Action
j2 j2 j2 j2 j2 j2 j2
2. After drug administration has occurred, the amount of drug in the blood that is free to
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
bind at specific target sites is referred to as
j2 j2 j2 j2 j2 j2 j2 j2
a. the therapeutic dose.
j2 j2
b. first-pass effects. j2
c. bioavailability.
d. ED50.
Answer: c j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
3. The specific molecular changes that occur when a drug binds to a particular target site
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
or receptor are referred to as
j2 j2 j2 j2 j2
a. drug effects. j2
b. drug action. j2
c. side effects. j2
d. placebo effects. j2
Answer: b j2
Textbook Reference: Pharmacology: The Science of Drug Action
j2 j2 j2 j2 j2 j2 j2
4. Which of the follo ng is not a possible explanation for placebo effects?
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. Pavlovian conditioning j2
b. Genetic variation j2
c. Drug competition j2
d. Expectation of outcome j2 j2
Answer: c j2
Textbook Reference: Pharmacology: The Science of Drug Action
j2 j2 j2 j2 j2 j2 j2
Page 1 of 247
j2 j2 j2
,5. The administration of oxytocin has been proposed as a treatment for autism. j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
6. Which factor does not affect the pharmacokinetics of a drug?
j2 j2 j2 j2 j2 j2 j2 j2 j2
a. Route of administration
j2 j2
b. Lipid solubility
j2
c. Depot binding j2
d. Drug action
j2
Answer: d j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
7. First-pass metabolism occurs when drugs are taken
j2 j2 j2 j2 j2 j2
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
8. The area postrema is one area in the brain where the
j2 j2 is not complete.
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. cerebrospinal fluid j2
b. blood–brain barrier j2
c. choroid plexus j2
d. phospholipid membrane j2
Answer: b j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
9. First-pass metabolism occurs th orally administered drugs because
j2 j2 j2j2 j2 j2 j2 j2
a. their absorption is slowed by food.
j2 j2 j2 j2 j2
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j
general circulation.
2 j2
c. drugs must first survive the acidic environment of the stomach.
j2 j2 j2 j2 j2 j2 j2 j2 j2
d. salivary enzymes in the mouth begin the process of metabolism.
j2 j2 j2 j2 j2 j2 j2 j2 j2
Answer: b j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
10. Toxic substances in the blood trigger a vomiting response by activating the
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. blood–brain barrier. j2
b. choroid plexus. j2
c. area postrema.
j2
d. median eminence. j2
Page 2 of 247
j2 j2 j2
, Answer: c j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
11. Drugs administered _ have the most rapid onset of action.
j2 j2 j2 j2 j2 j2 j2 j2
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
12. Ionization of a drug depends on the of the solution and the
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
of the drug.
j2 j2
a. pH; pKa
j2
b. pKa; pH j2
c. concentration; lipid solubility j2 j2
d. pH; concentration
j2
Answer: a j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
13. The absorption of a drug depends on all of the follo ng except
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. lipid solubility.
j2
b. ionization.
c. body temperature.
j2
d. the concentration of the drug.
j2 j2 j2 j2
Answer: c j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
14. Drugs that are should be avoided by women of childbearing age.
j2 j2 j2 j2 j2 j2 j2 j2 j2
a. teratogenic
b. able to cross the placental barrier
j2 j2 j2 j2 j2
c. psychoactive
d. highly lipid-soluble j2
Answer: a j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
15. Agents that induce developmental abnormalities in a fetus are known as
j2 j2 j2 j2 j2 j2 j2 j2 j2 j2
a. psychoactive drugs. j2
b. illicit drugs. j2
c. teratogens.
d. placental drugs. j2
Answer: c j2
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
j2 j2 j2 j2 j2 j2
16. Depot binding is said to occur when drugs
j2 j2 j2 j2 j2 j2 j2
a. bind to their target sites.
j2 j2 j2 j2
Page 3 of 247
j2 j2 j2
