Immunology Practice Exam with
Complete Solutions
Infection with HIV results in which of the following?
A. Immunodeficiency
B. Hypersensitivity disease
C. Allergic reaction
D. Autoimmune disease
E. Genetic disorder - ANS-immunodeficiency
Indicate whether the statement is true or false and explain why.
Booster shots are necessary because repeated exposure to an antigen builds a
stronger immune response. - ANS-True, each time the body is exposed to an antigen
the adaptive immune response remembers the antigen a litter better each time.
Therefore, with each subsequent exposure the immune response reaction time is faster
and can more rapidly and easily adapt to fight the antigen.
Indicate whether the statement is true or false and explain why.
Our bodies face the greatest onslaught from foreign invaders through the skin. - ANS-
False, most invaders enter the body through the mucous membranes.
The immune system is composed of two "arms" or "branches" - the innate and the
adaptive. Both branches operate completely independent on one another and there are
no shared cell types between them.
True or False? - ANS-False
Conditions in which the immune system attacks self-antigens are known as: - ANS-
autoimmune
Which of the following cell types are lymphocytes?
A. Neutrophils
B. Erythrocytes
C. Mast cells
D. Macrophages
E. T cells - ANS-T cells
,Which of the following is the BEST example of a hypersensitivity reaction?
A. T cells responding vigorously to the flu virus
B. T cells attacking the myelin sheath of nerves resulting in paralysis
C. Anemia as a result of iron deficiency
D. Inflammation of the airways in response to pollen
E. B cells failing to respond to HIV allowing it to replicate out of control - ANS-
inflammation of the airways in response to pollen
__________ involves the use of antibodies to fight pathogens. Antibodies are produced
by B-cells and can be found in body fluids. - ANS-Humoral
All blood cells in an adult human can trace their ancestry to which compartment within
the body?
A. Thymus
B. Bone marrow
C. Lymph node
D. Peyer's patch
E. Spleen - ANS-bone marrow
From which of the following stem cells are DCs derived?
A. CLP
B. CMP
C. CEP
D. Both A and B
E. A, B, and C - ANS-CLP and CMP
What level of gene expression is regulated by such factors as Notch1, GATA-2, and
Bmi-1?
A. Replication
B. Transcription
C. RNA processing
D. Translation
E. Regulation - ANS-transcription
Which of the following is NOT descended from the common lymphoid progenitor?
A. T cells
B. NK cells
C. B cells
D. Eosinophils - ANS-eosinophils
,A cell is isolated from secondary lymphoid tissue. The cell has the following surface
markers: CD2, CD8, CD45, and CD56. This cell is:
A. B cell
B. TH cell
C. TC cell
D. NK cell
E. Either TH cell or TC cell - ANS-NK cell
Which about the spleen is false:
A. It filters blood
B. It defends by initiating macrophages to remove microorganisms in blood and
phagocytose them
C. Contains red pulp, white pulp, and marginal zones
D. It is the source of lymphocytes before birth and enables lymphocytes to develop into
T cells - ANS-it is the source of lymphocytes before birth and enables lymphocytes to
develop into T cells
Name the macrophage associated with the liver: - ANS-Kupffer cell
Name 3 antigen-presenting cells: - ANS-1. monocytes
2. macrophages
3. dendritic cells
IL-2 acts on several cell types thus regulating multiple immune processes. IL-2 is said to
be:
A. Antagonistic
B. Cascade inducible
C. Pleiotropic
D. Redundant
E. Synergistic - ANS-pleiotropic
Which of the following is associated with preventing (or stopping) viral infection?
A. TNF-α
B. IL-2
C. IL-4
D. INF-α
E. All of the above - ANS-INF-α
Which of the following are not associated with inflammation caused by tissue injury?
A. Vasodilation occurs in response to cytokines that is released by damaged cells
B. Antibodies are produced by B cells
, C. The passage of neutrophils through capillary walls
D. Endothelial cells begin expressing surface molecules that allow for interaction with
neutrophils, a process referred to as a margination - ANS-antibodies are produced by B
cells
Which of the following is the CORRECT relationship? __________ on __________
recognize __________ on __________
A. PRRs; macrophages; PAMPs; pathogens
B. PRRs; pathogens; PAMPs; macrophages
C. PAMPs; macrophages; PRRs; pathogens
D. PAMPs; neutrophils; PRRs; pathogens
E. PRRs; macrophages; PAMPs; neutrophils - ANS-PRRs; macrophages; PAMPs;
pathogens
Name a cell of the innate immune system that is phagocytic? - ANS-neutrophil
A person with genetic defects in genes associated TLR 7 and 8 would most likely be
more susceptible to which of the following?
A. Mycobacterium spp. infections
B. Parasitic worm infections
C. DNA virus infections
D. RNA virus infections - ANS-RNA virus infections
Name three human organs or areas of the body where you would expect to find
significant levels of antimicrobial proteins. - ANS-1. skin
2. mucous membranes
3. respiratory tract
Define cytokine. - ANS-proteins that regulate the immune response
Select the leukocyte that is best described by each statement.
Cells that help activate B cells to secrete antibodies and macrophages to destroy
ingested microbes.
A. Basophils
B. Dendritic cells
C. Eosinophils
D. Natural killer cells
E. Neutrophils
F. T helper cells - ANS-T helper cells
Select the leukocyte that is best described by each statement.
Complete Solutions
Infection with HIV results in which of the following?
A. Immunodeficiency
B. Hypersensitivity disease
C. Allergic reaction
D. Autoimmune disease
E. Genetic disorder - ANS-immunodeficiency
Indicate whether the statement is true or false and explain why.
Booster shots are necessary because repeated exposure to an antigen builds a
stronger immune response. - ANS-True, each time the body is exposed to an antigen
the adaptive immune response remembers the antigen a litter better each time.
Therefore, with each subsequent exposure the immune response reaction time is faster
and can more rapidly and easily adapt to fight the antigen.
Indicate whether the statement is true or false and explain why.
Our bodies face the greatest onslaught from foreign invaders through the skin. - ANS-
False, most invaders enter the body through the mucous membranes.
The immune system is composed of two "arms" or "branches" - the innate and the
adaptive. Both branches operate completely independent on one another and there are
no shared cell types between them.
True or False? - ANS-False
Conditions in which the immune system attacks self-antigens are known as: - ANS-
autoimmune
Which of the following cell types are lymphocytes?
A. Neutrophils
B. Erythrocytes
C. Mast cells
D. Macrophages
E. T cells - ANS-T cells
,Which of the following is the BEST example of a hypersensitivity reaction?
A. T cells responding vigorously to the flu virus
B. T cells attacking the myelin sheath of nerves resulting in paralysis
C. Anemia as a result of iron deficiency
D. Inflammation of the airways in response to pollen
E. B cells failing to respond to HIV allowing it to replicate out of control - ANS-
inflammation of the airways in response to pollen
__________ involves the use of antibodies to fight pathogens. Antibodies are produced
by B-cells and can be found in body fluids. - ANS-Humoral
All blood cells in an adult human can trace their ancestry to which compartment within
the body?
A. Thymus
B. Bone marrow
C. Lymph node
D. Peyer's patch
E. Spleen - ANS-bone marrow
From which of the following stem cells are DCs derived?
A. CLP
B. CMP
C. CEP
D. Both A and B
E. A, B, and C - ANS-CLP and CMP
What level of gene expression is regulated by such factors as Notch1, GATA-2, and
Bmi-1?
A. Replication
B. Transcription
C. RNA processing
D. Translation
E. Regulation - ANS-transcription
Which of the following is NOT descended from the common lymphoid progenitor?
A. T cells
B. NK cells
C. B cells
D. Eosinophils - ANS-eosinophils
,A cell is isolated from secondary lymphoid tissue. The cell has the following surface
markers: CD2, CD8, CD45, and CD56. This cell is:
A. B cell
B. TH cell
C. TC cell
D. NK cell
E. Either TH cell or TC cell - ANS-NK cell
Which about the spleen is false:
A. It filters blood
B. It defends by initiating macrophages to remove microorganisms in blood and
phagocytose them
C. Contains red pulp, white pulp, and marginal zones
D. It is the source of lymphocytes before birth and enables lymphocytes to develop into
T cells - ANS-it is the source of lymphocytes before birth and enables lymphocytes to
develop into T cells
Name the macrophage associated with the liver: - ANS-Kupffer cell
Name 3 antigen-presenting cells: - ANS-1. monocytes
2. macrophages
3. dendritic cells
IL-2 acts on several cell types thus regulating multiple immune processes. IL-2 is said to
be:
A. Antagonistic
B. Cascade inducible
C. Pleiotropic
D. Redundant
E. Synergistic - ANS-pleiotropic
Which of the following is associated with preventing (or stopping) viral infection?
A. TNF-α
B. IL-2
C. IL-4
D. INF-α
E. All of the above - ANS-INF-α
Which of the following are not associated with inflammation caused by tissue injury?
A. Vasodilation occurs in response to cytokines that is released by damaged cells
B. Antibodies are produced by B cells
, C. The passage of neutrophils through capillary walls
D. Endothelial cells begin expressing surface molecules that allow for interaction with
neutrophils, a process referred to as a margination - ANS-antibodies are produced by B
cells
Which of the following is the CORRECT relationship? __________ on __________
recognize __________ on __________
A. PRRs; macrophages; PAMPs; pathogens
B. PRRs; pathogens; PAMPs; macrophages
C. PAMPs; macrophages; PRRs; pathogens
D. PAMPs; neutrophils; PRRs; pathogens
E. PRRs; macrophages; PAMPs; neutrophils - ANS-PRRs; macrophages; PAMPs;
pathogens
Name a cell of the innate immune system that is phagocytic? - ANS-neutrophil
A person with genetic defects in genes associated TLR 7 and 8 would most likely be
more susceptible to which of the following?
A. Mycobacterium spp. infections
B. Parasitic worm infections
C. DNA virus infections
D. RNA virus infections - ANS-RNA virus infections
Name three human organs or areas of the body where you would expect to find
significant levels of antimicrobial proteins. - ANS-1. skin
2. mucous membranes
3. respiratory tract
Define cytokine. - ANS-proteins that regulate the immune response
Select the leukocyte that is best described by each statement.
Cells that help activate B cells to secrete antibodies and macrophages to destroy
ingested microbes.
A. Basophils
B. Dendritic cells
C. Eosinophils
D. Natural killer cells
E. Neutrophils
F. T helper cells - ANS-T helper cells
Select the leukocyte that is best described by each statement.
