March et al 2004 question with correct answers

Aim Investigate the effectiveness of fluoxetine, CBT, a combination of both and a placebo condition on the treatment of depression in adolescents Method · Randomised controlled trial on 439 adolescent patients diagnosed with major depressive disorder at 13 clinics across the USA · The trial focused specifically on comparisons between an SSRI and CBT in the treatment of adolescent depression. · The study had four treatment conditions, to which the participants were assigned randomly fluoxetine (an SSRI) alone CBT alone fluoxetine and CBT combined placebo. · End of 12 weeks = placebo patients informed · 3 indicators used in treatments to characterise effectiveness of treatment in terms of reductions of symptoms of disorder o Response rate: 50% decrease in scores on standardised depression scale (HAM-D) o Remission rate: few or no symptoms of depression (score less than 7 on HAM-D) Relapse rate: recurrence of past condition Results · 12 weeks = placebo (35%), fluoxentine (61%), CBT (44%), both (71%) · 18 weeks = placebo (dis.), fluoxentine (69%), CBT (65%), both (85%) · 36 weeks = placebo (dis.), fluoxentine (81%), CBT (81%), both (86%) · Fluoxentine + Cognitive Behavioural Therapy = most effective short-term and long-term · Placebo = least effective CBT = short-term barely more effective than placebo but improves long-term Conclusions The researchers concluded that the combination treatment presented a more favourable risk-benefit ratio for adolescents Critical Thinking Strengths: · Specific comparison of fluoxetine with CBT o Many studies more generally compare second-generation antidepressants The administration of CBT varies widely from practitioner to practitioner Terms of both the specific techniques employed and the expertise of the practitioner Does not offer full control over all of the variables that might have influenced the findings Data triangulation Randomly assigned Purposive sampling Reductionist approach Ethics · Provide support for those in the placebo group Clinical management (no undue stress or harm) Research Method · Provide support for those in the placebo group Clinical management (no undue stress or harm) Add or remove terms You can also click the terms or definitions to blur or reveal them