Zairra Mari O. Basig
PATHOPHYSIOLOGY on
R IS K F AC T O R S
ULCERATIVE COLITIS R IS K F AC T O R S
genetic factors Stress
age a ut o im m u ne c on d it i o n
race/ethnicity e nvi ro n m en t a l f act o rs
ORI GI N A TE S I N T H E
R E CT U M AN D L OW E R
COLON
S P R E A DS T O T H E
EN T IR E CO LO N co l on ’s m uc o sa l su rf a ce
be c om es d ar k , re d, a n d
velvety
MUCOSA
dr ain p uru le nt pu s,
be com e nec ro tic , A bsc es se s fo rm a nd
an d u lc era te . co al es ce i nt o ul ce rs .
dev e l o ps di f fu s e u lc e r a ti o n ,
w it h h e mo r r h ag e , abscesses NECROSIS
c on g e s t io n , ed e m a , a n d
e xu d a t i ve i n fl a m m a ti o n
Sloughing a b s c e s s e s he a l, sc a r ri n g
a n d t h i c k e ni n g m ay a pp e ar
i n t h e b o w el ’ s i nn e r m u sc l e
bl oo dy , mu cu s- fi ll ed layer.
stools
co lo n na rr ow s, s ho rt en s,
an d lo se s it s
ch ar ac te ri st ic p ou ch es
COMPLICATIONS c o l o n g oe s th ro u g h
i n f l a mm at io n a n d
pr o gr es s io n ma y l ea d t o ulceration.
in t es ti n al o bs t ru ct i on ,
de h yd ra t io n, a n d ma j or f lu i d
an d e le c tr ol yt e i mb a la nc es
ULCERATIVE COLITIS
This inflammatory disease causes ulcerations of the mucosa in the colon. It commonly
occurs as a chronic condition. As many as 1 out of 1,000 people may have ulcerative
colitis. Peak occurrence is between ages 15 and 30 and between ages 50 and 70. The
incidence of ulcerative colitis is equal among men and women.
How it happens
Although the cause of ulcerative colitis is unknown, it may be related to an abnormal
immune response in the GI tract, possibly associated with genetic factors.
Lymphocytes (T cells) in people with ulcerative colitis may have cytotoxic effects on
the epithelial cells of the colon. Stress doesn’t cause the disorder, but it can increase
the severity of an attack. Although no specific organism has been linked to ulcerative
colitis, infection hasn’t been ruled out.
PATHOPHYSIOLOGY on
R IS K F AC T O R S
ULCERATIVE COLITIS R IS K F AC T O R S
genetic factors Stress
age a ut o im m u ne c on d it i o n
race/ethnicity e nvi ro n m en t a l f act o rs
ORI GI N A TE S I N T H E
R E CT U M AN D L OW E R
COLON
S P R E A DS T O T H E
EN T IR E CO LO N co l on ’s m uc o sa l su rf a ce
be c om es d ar k , re d, a n d
velvety
MUCOSA
dr ain p uru le nt pu s,
be com e nec ro tic , A bsc es se s fo rm a nd
an d u lc era te . co al es ce i nt o ul ce rs .
dev e l o ps di f fu s e u lc e r a ti o n ,
w it h h e mo r r h ag e , abscesses NECROSIS
c on g e s t io n , ed e m a , a n d
e xu d a t i ve i n fl a m m a ti o n
Sloughing a b s c e s s e s he a l, sc a r ri n g
a n d t h i c k e ni n g m ay a pp e ar
i n t h e b o w el ’ s i nn e r m u sc l e
bl oo dy , mu cu s- fi ll ed layer.
stools
co lo n na rr ow s, s ho rt en s,
an d lo se s it s
ch ar ac te ri st ic p ou ch es
COMPLICATIONS c o l o n g oe s th ro u g h
i n f l a mm at io n a n d
pr o gr es s io n ma y l ea d t o ulceration.
in t es ti n al o bs t ru ct i on ,
de h yd ra t io n, a n d ma j or f lu i d
an d e le c tr ol yt e i mb a la nc es
ULCERATIVE COLITIS
This inflammatory disease causes ulcerations of the mucosa in the colon. It commonly
occurs as a chronic condition. As many as 1 out of 1,000 people may have ulcerative
colitis. Peak occurrence is between ages 15 and 30 and between ages 50 and 70. The
incidence of ulcerative colitis is equal among men and women.
How it happens
Although the cause of ulcerative colitis is unknown, it may be related to an abnormal
immune response in the GI tract, possibly associated with genetic factors.
Lymphocytes (T cells) in people with ulcerative colitis may have cytotoxic effects on
the epithelial cells of the colon. Stress doesn’t cause the disorder, but it can increase
the severity of an attack. Although no specific organism has been linked to ulcerative
colitis, infection hasn’t been ruled out.
