USMLE STEP 1 PRACTICE EXAM 2025/2026 QUESTIONS
WITH ANSWERS GRADED A+
Hormone to test for menopause. - ✔✔high FSH
✔✔Treatment of Heparin Induced Thrombocytopenia - ✔✔Direct thrombin inhibitors-
Agatroban
Then protamine sulfate
✔✔PT or PTT for Heparin - ✔✔PTT
✔✔PT or PTT for Warfarin - ✔✔PT
✔✔Skin necrosis from warfarin, what do you do? - ✔✔Give heparin
✔✔Antidote to excessive thrombolytics - ✔✔Aminocaproic acid
✔✔Glanzmanns Thrombasthenia - ✔✔GPIIb/IIIa- platelet adhesion
✔✔Bernard soulier - ✔✔Gp1b
✔✔Aspirin decreases platelet adehsion, activation or aggregation? - ✔✔Activation
✔✔Drugs that decrease platelet activation - ✔✔aspirin, toclopidine, clopidogrel- block
ADP receptors
✔✔Drugs that decrease aggregation - ✔✔abciximab, eptifibatide, tirofiban
✔✔Why do sulfonamides decrease increase PT in patients on warfarin? -
✔✔Sulfonamides displace the weakly but extensively bound warfarin on plasma
proteins. This is different mechanism from cimetidine which increase P450
✔✔Onset, peak effect and duration of lispro - ✔✔onset: 0.3-0.5hrs
peak effect: 1-2 hrs
duration: 2-4hrs
✔✔Onset peak effect and duration of regular - ✔✔onset: 0.5-1hrs
peak effect: 2-4hrs
duration: 5-7hrs
✔✔Onset, peak effect and duration of glargine - ✔✔onset: 1hr
peak effect: no peak
duration>24hrs
WITH ANSWERS GRADED A+
Hormone to test for menopause. - ✔✔high FSH
✔✔Treatment of Heparin Induced Thrombocytopenia - ✔✔Direct thrombin inhibitors-
Agatroban
Then protamine sulfate
✔✔PT or PTT for Heparin - ✔✔PTT
✔✔PT or PTT for Warfarin - ✔✔PT
✔✔Skin necrosis from warfarin, what do you do? - ✔✔Give heparin
✔✔Antidote to excessive thrombolytics - ✔✔Aminocaproic acid
✔✔Glanzmanns Thrombasthenia - ✔✔GPIIb/IIIa- platelet adhesion
✔✔Bernard soulier - ✔✔Gp1b
✔✔Aspirin decreases platelet adehsion, activation or aggregation? - ✔✔Activation
✔✔Drugs that decrease platelet activation - ✔✔aspirin, toclopidine, clopidogrel- block
ADP receptors
✔✔Drugs that decrease aggregation - ✔✔abciximab, eptifibatide, tirofiban
✔✔Why do sulfonamides decrease increase PT in patients on warfarin? -
✔✔Sulfonamides displace the weakly but extensively bound warfarin on plasma
proteins. This is different mechanism from cimetidine which increase P450
✔✔Onset, peak effect and duration of lispro - ✔✔onset: 0.3-0.5hrs
peak effect: 1-2 hrs
duration: 2-4hrs
✔✔Onset peak effect and duration of regular - ✔✔onset: 0.5-1hrs
peak effect: 2-4hrs
duration: 5-7hrs
✔✔Onset, peak effect and duration of glargine - ✔✔onset: 1hr
peak effect: no peak
duration>24hrs
